Long-term immune cell profiling in stroke patients with or without infections

Autor: Nina Vindegaard Sørensen, Henrik Hasseldam, Flemming Fryd Johansen, Uffe Kristiansen, Karsten Overgaard, Helle Klingenberg Iversen, Rune Skovgaard Rasmussen

Publikováno v: International Journal of Neuroscience. :1-9

Infections are frequent complications in acute ischemic stroke and may be caused by an altered immune response influencing brain damage. We compared long-term immune responses in stroke patients with or without infections during the recovery period b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45843236d89aba4844874d1190238375
https://doi.org/10.1080/00207454.2022.2098733

Structure–activity studies of 3,9-diazaspiro[5.5]undecane-based γ-aminobutyric acid type A receptor antagonists with immunomodulatory effect

Autor: Francesco Bavo, Heleen de-Jong, Jonas Petersen, Christina Birkedahl Falk-Petersen, Rebekka Löffler, Emma Sparrow, Frederik Rostrup, Jannik Nicklas Eliasen, Kristine S. Wilhelmsen, Kasper Barslund, Christoffer Bundgaard, Birgitte Nielsen, Uffe Kristiansen, Petrine Wellendorph, Yury Bogdanov, Bente Frølund

The 3,9-diazaspiro[5.5]undecane-based compounds 2027 and 018 have previously been reported to be potent competitive γ-aminobutyric acid type A receptor (GABAAR) antagonists showing low cellular membrane permeability. Given the emerging peripheral ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1b8597a5aeec1385cffce2213ce18f
https://eprints.soton.ac.uk/454543/

Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr(128)Ala variant (rs2257020) in Xenopus oocytes

Autor: Nawid Madjroh, Uffe Kristiansen, Pella Cecilia Söderhielm, Joshua L. Smalley, Anders A. Jensen, Paul Davies

Publikováno v: Pharmacol Res
Madjroh, N, Davies, P A, Smalley, J L, Kristiansen, U, Söderhielm, P C & Jensen, A A 2021, ' Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr 128 Ala variant (rs2257020) in Xenopus oocytes ', Pharmacological Research, vol. 169, 105653 . https://doi.org/10.1016/j.phrs.2021.105653

The signalling characteristics of the Zinc-Activated Channel (ZAC), a member of the Cys-loop receptor (CLR) superfamily, are presently poorly elucidated. The ZACN polymorphism c.454G>A encoding for the Thr128Ala variation in ZAC is found in extremely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073a232df82964af2e1e7d718ac3b4ba
https://europepmc.org/articles/PMC8248299/

Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABAA receptors

Autor: Kasper Harpsøe, Christina Birkedahl Falk-Petersen, Tsonko M. Tsonkov, Uffe Kristiansen, David E. Gloriam, Malene Sofie Nielsen, Petrine Wellendorph, Bente Frølund, Christoffer Bundgaard

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Falk-Petersen, C B, Tsonkov, T M, Nielsen, M S, Harpsøe, K, Bundgaard, C, Frølund, B, Kristiansen, U, Gloriam, D E & Wellendorph, P 2020, ' Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA A receptors ', Scientific Reports, vol. 10, no. 1, 10078 . https://doi.org/10.1038/s41598-020-66821-0

Brain GABAΑ receptors are ionotropic receptors belonging to the class of Cys-loop receptors and are important drug targets for the treatment of anxiety and sleep disorders. By screening a compound library (2,112 compounds) at recombinant human α4β

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3bf28828f4618689a1ced9e7f024b0d

Increasing cellular lifespan with a flow system in organotypic culture of the Laterodorsal Tegmentum (LDT)

Autor: Cesar R Romero-Leguizamón, Mohamed R. Elnagar, Kristi A. Kohlmeier, Uffe Kristiansen

Publikováno v: Leguizamon, C R R, Elnagar, M, Kristiansen, U & Kohlmeier, K A 2019, ' Increasing cellular lifespan with a flow system in organotypic culture of the Laterodorsal Tegmentum (LDT) ', Scientific Reports, pp. 1-11 . https://doi.org/10.1038/s41598-018-37606-3
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports

Organotypic brain culture is an experimental tool widely used in neuroscience studies. One majordrawback of this technique is reduced neuronal survival across time, which is likely exacerbated by theloss of blood flow. We have designed a novel, tube

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa21580572d3ab0027ac30dad5fa566
https://curis.ku.dk/ws/files/214090455/Art_Organotypic_LDT.pdf