Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Ueli Schibler"'
Autor:
Jonathan Aryeh Sobel, Irina Krier, Teemu Andersin, Sunil Raghav, Donatella Canella, Federica Gilardi, Alexandra Styliani Kalantzi, Guillaume Rey, Benjamin Weger, Frédéric Gachon, Matteo Dal Peraro, Nouria Hernandez, Ueli Schibler, Bart Deplancke, Felix Naef, CycliX consortium
Publikováno v:
PLoS Biology, Vol 15, Iss 4, p e2001069 (2017)
Many organisms exhibit temporal rhythms in gene expression that propel diurnal cycles in physiology. In the liver of mammals, these rhythms are controlled by transcription-translation feedback loops of the core circadian clock and by feeding-fasting
Externí odkaz:
https://doaj.org/article/7d6fad3d697d43e5a06a2218bd903837
Autor:
Thomas Bollinger, Ueli Schibler
Publikováno v:
Swiss Medical Weekly, Vol 144, Iss 2930 (2014)
Most physiological processes in our body oscillate in a daily fashion. These include cerebral activity (sleep-wake cycles), metabolism and energy homeostasis, heart rate, blood pressure, body temperature, renal activity, and hormone as well as cytoki
Externí odkaz:
https://doaj.org/article/df7bb51c0ad640279dfee45743c4d428
Autor:
Maud Demarque, Ueli Schibler
Publikováno v:
eLife, Vol 2 (2013)
Using a clever combination of genetic and biochemical tools researchers have shown that a transcription factor called USF1 has a central role in determining how mutations of the Clock gene manifest themselves in the behaviour of different mouse strai
Externí odkaz:
https://doaj.org/article/d762a89dbfc2400fad4ca5686fb1042f
Autor:
Gwendal Le Martelot, Donatella Canella, Laura Symul, Eugenia Migliavacca, Federica Gilardi, Robin Liechti, Olivier Martin, Keith Harshman, Mauro Delorenzi, Béatrice Desvergne, Winship Herr, Bart Deplancke, Ueli Schibler, Jacques Rougemont, Nicolas Guex, Nouria Hernandez, Felix Naef, CycliX Consortium
Publikováno v:
PLoS Biology, Vol 10, Iss 11, p e1001442 (2012)
Interactions of cell-autonomous circadian oscillators with diurnal cycles govern the temporal compartmentalization of cell physiology in mammals. To understand the transcriptional and epigenetic basis of diurnal rhythms in mouse liver genome-wide, we
Externí odkaz:
https://doaj.org/article/39ea2125b291414090a9397d877a0053
Autor:
Gwendal Le Martelot, Thierry Claudel, David Gatfield, Olivier Schaad, Benoît Kornmann, Giuseppe Lo Sasso, Antonio Moschetta, Ueli Schibler
Publikováno v:
PLoS Biology, Vol 7, Iss 9, p e1000181 (2009)
In mammals, many aspects of behavior and physiology, and in particular cellular metabolism, are coordinated by the circadian timing system. Molecular clocks are thought to rely on negative feedback loops in clock gene expression that engender oscilla
Externí odkaz:
https://doaj.org/article/e8209cbc4cf448c8a011287830cc48ec
Publikováno v:
PLoS Biology, Vol 5, Iss 2, p e34 (2007)
The mammalian circadian timing system consists of a master pacemaker in neurons of the suprachiasmatic nucleus (SCN) and clocks of a similar molecular makeup in most peripheral body cells. Peripheral oscillators are self-sustained and cell autonomous
Externí odkaz:
https://doaj.org/article/4bbfe03326e24f629afe16e1e5e356eb
Autor:
Steven A Brown, Fabienne Fleury-Olela, Emi Nagoshi, Conrad Hauser, Cristiana Juge, Christophe A Meier, Rachel Chicheportiche, Jean-Michel Dayer, Urs Albrecht, Ueli Schibler
Publikováno v:
PLoS Biology, Vol 3, Iss 10, p e338 (2005)
Mammalian circadian behavior is governed by a central clock in the suprachiasmatic nucleus of the brain hypothalamus, and its intrinsic period length is believed to affect the phase of daily activities. Measurement of this period length, normally acc
Externí odkaz:
https://doaj.org/article/212145b8e0bf4220bd4735f5c1b4f7e2
Publikováno v:
Journal of Biological Rhythms. 38:119-124
Autor:
Georgia, Katsioudi, Alejandro, Osorio-Forero, Flore, Sinturel, Claudia, Hagedorn, Florian, Kreppel, Ueli, Schibler, David, Gatfield
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2482
There is high interest in investigating the daily dynamics of gene expression in mammalian organs, for example, in liver. Such studies help to elucidate how and with what kinetics peripheral clocks integrate circadian signals from the suprachiasmatic
Autor:
Ueli Schibler
Publikováno v:
Genes Dev
In mammals, virtually all body cells harbor cell-autonomous and self-sustained circadian oscillators that rely on delayed negative feedback loops in gene expression. Transcriptional activation and repression play a major role in keeping these clocks