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Publikováno v:
Journal of Biological Rhythms. 38:119-124
Autor:
Jonathan Aryeh Sobel, Irina Krier, Teemu Andersin, Sunil Raghav, Donatella Canella, Federica Gilardi, Alexandra Styliani Kalantzi, Guillaume Rey, Benjamin Weger, Frédéric Gachon, Matteo Dal Peraro, Nouria Hernandez, Ueli Schibler, Bart Deplancke, Felix Naef, CycliX consortium
Publikováno v:
PLoS Biology, Vol 15, Iss 4, p e2001069 (2017)
Many organisms exhibit temporal rhythms in gene expression that propel diurnal cycles in physiology. In the liver of mammals, these rhythms are controlled by transcription-translation feedback loops of the core circadian clock and by feeding-fasting
Externí odkaz:
https://doaj.org/article/7d6fad3d697d43e5a06a2218bd903837
Autor:
Georgia, Katsioudi, Alejandro, Osorio-Forero, Flore, Sinturel, Claudia, Hagedorn, Florian, Kreppel, Ueli, Schibler, David, Gatfield
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2482
There is high interest in investigating the daily dynamics of gene expression in mammalian organs, for example, in liver. Such studies help to elucidate how and with what kinetics peripheral clocks integrate circadian signals from the suprachiasmatic
Autor:
Ueli Schibler
Publikováno v:
Genes Dev
In mammals, virtually all body cells harbor cell-autonomous and self-sustained circadian oscillators that rely on delayed negative feedback loops in gene expression. Transcriptional activation and repression play a major role in keeping these clocks
Autor:
Ueli Schibler
Publikováno v:
Molecular Cell. 78:805-807
The amplitude of circadian rhythms dampens with age, but Levine et al. (2020) now show that nicotinamide adenine dinucleotide (NAD+) can restore robust circadian gene expression and behavior in aged mice through SIRT1-dependent deacetylation of the c
Autor:
Ueli Schibler
Publikováno v:
Molecular Cell. 81:4958-4959
Autor:
Thomas Bollinger, Ueli Schibler
Publikováno v:
Swiss Medical Weekly, Vol 144, Iss 2930 (2014)
Most physiological processes in our body oscillate in a daily fashion. These include cerebral activity (sleep-wake cycles), metabolism and energy homeostasis, heart rate, blood pressure, body temperature, renal activity, and hormone as well as cytoki
Externí odkaz:
https://doaj.org/article/df7bb51c0ad640279dfee45743c4d428
Autor:
Ueli Schibler, Charles J. Weitz, Charna Dibner, Andre Liani, Yann Emmenegger, Volodymyr Petrenko, Kai-Florian Storch, Luigi Bonacina, Claudia Hagedorn, Paul Franken, Flore Sinturel, Pascal Gos, Florian Kreppel, Darko Knutti
Publikováno v:
Genes Dev
Genes & development, vol. 35, no. 5-6, pp. 329-334
Genes and Development, Vol. 35, No 5-6 (2021) pp. 329-334
Genes & development, vol. 35, no. 5-6, pp. 329-334
Genes and Development, Vol. 35, No 5-6 (2021) pp. 329-334
It has been assumed that the suprachiasmatic nucleus (SCN) synchronizes peripheral circadian oscillators. However, this has never been convincingly shown, since biochemical time series experiments are not feasible in behaviorally arrhythmic animals.
Autor:
Maud Demarque, Ueli Schibler
Publikováno v:
eLife, Vol 2 (2013)
Using a clever combination of genetic and biochemical tools researchers have shown that a transcription factor called USF1 has a central role in determining how mutations of the Clock gene manifest themselves in the behaviour of different mouse strai
Externí odkaz:
https://doaj.org/article/d762a89dbfc2400fad4ca5686fb1042f