Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Ueli Gubler"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 4, p e0011303 (2023)
Lymphatic filariasis is a debilitating illness with an estimated 50 million cases as of 2018. The majority of cases are caused by the parasitic worm W. bancrofti and additional cases by the worms B. malayi and B. timori. Dihydrofolate reductase (DHFR
Externí odkaz:
https://doaj.org/article/8c20d36c91bc4e7eb05fa27a07735415
Autor:
Andrew M Tobias, Dea Toska, Keith Lange, Tyler Eck, Rohit Bhat, Cheryl A Janson, David P Rotella, Ueli Gubler, Nina M Goodey
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197173 (2018)
Filariasis is a tropical disease caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. Known inhibitors of dihydrofolate reductase (DHFR) have been previously shown to kill Brugia malayi nematodes and to inhibit Brugia malayi DHFR
Externí odkaz:
https://doaj.org/article/2c8a0df7e2ef4f8b811d5074508981ba
Autor:
Haoshuang Zhao, Naoko Tanaka, Wei Chu, Ueli Gubler, Michael Sabio, Sid Topiol, Peter Tolias, Kuo-Sen Huang
Publikováno v:
Medical Research Archives. 8
By analyzing KRas and HRas X-ray structures, we developed a novel strategy that involves the design of a series of “synthetic” or “artificial” KRas mutations, namely T20I, D57E, D57F, T58A, T58V, and G60A, individually introduced into KRas wi
Autor:
Ueli Gubler, Nina M. Goodey, John J. Siekierka, Romy Perez-Abraham, Karla Garabiles Sanchez, Melany Alfonso
Publikováno v:
Protein Expression and Purification. 128:81-85
Brugia malayi (B. malayi) is one of the three causative agents of lymphatic filariasis, a neglected parasitic disease. Current literature suggests that dihydrofolate reductase is a potential drug target for the elimination of B. malayi. Here we repor
Autor:
Lisa Hazard, Kirsten Monsen, Nina M. Goodey, Allyssa Angel, Ueli Gubler, Patricia Román Reyes
Publikováno v:
The FASEB Journal. 33
A key problem when developing molecular diagnostic techniques is procuring target detection probes. The need of a stable and selective probe is necessary for accurate target identification in disea...
Autor:
Ueli Gubler, Uththara Liyanagunawardana, Thomas Candela, Nina M. Goodey, Jaclyn Catalano, Natalia E. Reis, Michael Little, Katherine Leon H, Tyler Eck, Seema Patel, Cheryl A. Janson
Publikováno v:
Archives of Biochemistry and Biophysics. 692:108545
Many antibacterial and antiparasitic drugs work by competitively inhibiting dihydrofolate reductase (DHFR), a vital enzyme in folate metabolism. The interactions between inhibitors and DHFR active site residues are known in many homologs but the cont
Publikováno v:
The FASEB Journal. 32
Autor:
Cheryl A. Janson, Keith Richard Lange, Dea Toska, Andrew M. Tobias, David P. Rotella, Nina M. Goodey, Tyler Eck, Rohit Bhat, Ueli Gubler
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197173 (2018)
PLoS ONE
PLoS ONE
Filariasis is a tropical disease caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. Known inhibitors of dihydrofolate reductase (DHFR) have been previously shown to kill Brugia malayi nematodes and to inhibit Brugia malayi DHFR
Autor:
Johannes Auer, Patrick Cramer, Alvin S. Stern, Ulrich Kohnert, Packman Kathryn E, Ueli Gubler, Martin Lanzendörfer, Silke Hansen, Guy Georges, Klaus Kaluza, Dirk Kostrewa, Stefan Ries, Kuo‑Sen Huang, Christiane Hartl, Tobias Koschubs, Stefan Jennewein, Olaf Mundigl, Stefan Dengl, Harald Dürr
Publikováno v:
Biochemical Journal
Hepsin is a type II transmembrane serine protease that is expressed in several human tissues. Overexpression of hepsin has been found to correlate with tumour progression and metastasis, which is so far best studied for prostate cancer, where more th
Autor:
Tina Molinaro, Robert Alan Goodnow, Louis M. Renzetti, Alexandra Hicks, Satish Choudhry, Xin Wei, Gesine J. Hermann, Qi Qiao, Anjula Pamidimukkala, A. Robert Catala, Maureen Hargaden, Jian Ping Lou, Nadine Tare, John O’Neil, Ueli Gubler, Karen Pozzani, David J Moore, Jennifer Santiago, Ruben Marcano, Paul Gillespie, Rachid Hamid, Noal Cohen, Hyesun Oh, Lisa C. F. Chao, Laura Singer, Jefferson Wright Tilley, Romyr Dominique, Grazyna Kurylko, Ying L. Li, Radhika Venkat, Achyutharao Sidduri, Matthew Blake Wright, Ann F. Hoffman, Shahid Tannu, Gary Cavallo, Nader Fotouhi, Thomas Egan, Martin Lamb, Jessica D. Ventre, Agnieszka Kowalczyk, D Lavelle, Helena Mancebo
Publikováno v:
Journal of Medicinal Chemistry. 53:3502-3516
The inhibition of LTB(4) binding to and activation of G-protein-coupled receptors BLT1 and BLT2 is the premise of a treatment for several inflammatory diseases. In a lead optimization effort starting with the leukotriene B(4) (LTB(4)) receptor antago