Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Udo Rüb"'
Autor:
Suna Lahut, Suzana Gispert, Özgür Ömür, Candan Depboylu, Kay Seidel, Jorge Antolio Domínguez-Bautista, Nadine Brehm, Hülya Tireli, Karl Hackmann, Caroline Pirkevi, Barbara Leube, Vincent Ries, Kerstin Reim, Nils Brose, Wilfred F. den Dunnen, Madrid Johnson, Zsuzsanna Wolf, Marc Schindewolf, Wiebke Schrempf, Kathrin Reetz, Peter Young, David Vadasz, Achilleas S. Frangakis, Evelin Schröck, Helmuth Steinmetz, Marina Jendrach, Udo Rüb, Ayşe Nazlı Başak, Wolfgang Oertel, Georg Auburger
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 5, Pp 619-631 (2017)
Parkinson's disease (PD) is a frequent neurodegenerative process in old age. Accumulation and aggregation of the lipid-binding SNARE complex component α-synuclein (SNCA) underlies this vulnerability and defines stages of disease progression. Determi
Externí odkaz:
https://doaj.org/article/f247356cd98c40f2b0349f1591cc83ae
Autor:
Lucas Nürnberger, René-Maxime Gracien, Pavel Hok, Stephanie-Michelle Hof, Udo Rüb, Helmuth Steinmetz, Rüdiger Hilker, Johannes C. Klein, Ralf Deichmann, Simon Baudrexel
Publikováno v:
NeuroImage: Clinical, Vol 13, Iss C, Pp 405-414 (2017)
Background: Histological evidence suggests that pathology in Parkinson's disease (PD) goes beyond nigrostriatal degeneration and also affects the cerebral cortex. Quantitative MRI (qMRI) techniques allow the assessment of changes in brain tissue comp
Externí odkaz:
https://doaj.org/article/7323adb0dd564888b98a90e68593bc5f
Autor:
Ewa Damrath, Melanie V Heck, Suzana Gispert, Mekhman Azizov, Joachim Nowock, Carola Seifried, Udo Rüb, Michael Walter, Georg Auburger
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002920 (2012)
Spinocerebellar Ataxia Type 2 (SCA2) is caused by expansion of a polyglutamine encoding triplet repeat in the human ATXN2 gene beyond (CAG)(31). This is thought to mediate toxic gain-of-function by protein aggregation and to affect RNA processing, re
Externí odkaz:
https://doaj.org/article/815fe744f4334f3f9d6909297a8b481f
Autor:
Suzana Gispert, Filomena Ricciardi, Alexander Kurz, Mekhman Azizov, Hans-Hermann Hoepken, Dorothea Becker, Wolfgang Voos, Kristina Leuner, Walter E Müller, Alexei P Kudin, Wolfram S Kunz, Annabelle Zimmermann, Jochen Roeper, Dirk Wenzel, Marina Jendrach, Moisés García-Arencíbia, Javier Fernández-Ruiz, Leslie Huber, Hermann Rohrer, Miguel Barrera, Andreas S Reichert, Udo Rüb, Amy Chen, Robert L Nussbaum, Georg Auburger
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5777 (2009)
BackgroundParkinson's disease (PD) is an adult-onset movement disorder of largely unknown etiology. We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessiv
Externí odkaz:
https://doaj.org/article/45f68ab49b2d403fa1646e411e62f433
Autor:
Adrian Danek, Jia Liu, Benedikt Bader, Udo Rüb, C. A. Pasqualucci, Maren C. Kiessling, Kay Seidel, Christoph Schmitz, W. F. A. den Dunnen, Lea T. Grinberg, Thomas Arzberger, Edson Amaro, Helmut Heinsen, Eduardo Joaquim Lopez Alho
Publikováno v:
Neuropathology and Applied Neurobiology. 45:230-243
AIMS: Quantitative estimation of cortical neurone loss in cases with chorea-acanthocytosis and its impact on laminar composition METHODS: We used unbiased stereological tools to estimate the degree of cortical pathology in serial gallocyanin-stained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5e19dec05e88e98f4daca99b0e646f
https://doi.org/10.1111/nan.12495
https://doi.org/10.1111/nan.12495
Autor:
Udo Rüb, Kay Seidel, Wilfred F. A. den Dunnen, Horst-Werner Korf, Ludger Schöls, Nina Heidemann, Mohamed Bouzrou, Rejko Krüger
Publikováno v:
Annals of Neurology. 81:898-903
Patient brains with Parkinson's disease or Dementia with Lewy bodies show aggregation of alpha-synuclein in pre-cerebellar brainstem structures. Furthermore, patients exhibit resting tremor, unstable gait and impaired balance which may be associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a49ca2354d39077f4540a3074d58b09c
https://doi.org/10.1002/ana.24937
https://doi.org/10.1002/ana.24937
Autor:
W. F. A. den Dunnen, Helmut Heinsen, Horst-Werner Korf, Jean Paul G. Vonsattel, Udo Rüb, Kay Seidel
Publikováno v:
Brain Pathology. 26:726-740
Huntington's disease (HD) is an autosomal dominantly inherited, and currently untreatable, neuropsychiatric disorder. This progressive and ultimately fatal disease is named after the American physician George Huntington and according to the underlyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::675116d1b91a82653a6d8c93af2b5a10
https://doi.org/10.1111/bpa.12426
https://doi.org/10.1111/bpa.12426
Autor:
Béla Melegh, Ewout R. Brunt, Mohamed Bouzrou, Horst-Werner Korf, Jeroen J de Vries, Michaela Fredrich, Kay Seidel, Georg Auburger, Wilfred F. A. den Dunnen, Udo Rüb, Inci Özerden, Sonny Siswanto
Publikováno v:
Brain Pathology. 27:345-355
The polyglutamine (polyQ) diseases are a group of genetically and clinically heterogeneous neurodegenerative diseases, characterized by the expansion of polyQ sequences in unrelated disease proteins, which form different types of neuronal aggregates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25977b07460b306e387657aaf4c23789
https://doi.org/10.1111/bpa.12412
https://doi.org/10.1111/bpa.12412
Autor:
Helmuth Steinmetz, Sarah C. Reitz, Rüdiger Hilker-Roggendorf, Johannes C. Klein, Simon Baudrexel, Stephanie-Michelle Hof, Pavel Hok, Lucas Nürnberger, René-Maxime Gracien, Ralf Deichmann, Udo Rüb
Publikováno v:
European Radiology. 27:1568-1576
T1 relaxometry is a promising tool for the assessment of microstructural changes during brain ageing. Previous cross-sectional studies demonstrated increasing T1 values in white and decreasing T1 values in grey matter over the lifetime. However, thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0652a22868406526cb17169768f562be
https://doi.org/10.1007/s00330-016-4485-1
https://doi.org/10.1007/s00330-016-4485-1
Autor:
Horst-Werner Korf, Katharina Stratmann, Helmut Heinsen, Kay Seidel, Domenico Del Turco, Udo Rüb, Wilfred F. A. den Dunnen
Publikováno v:
Current alzheimer research. 13(10):1178-1197
The human brainstem is involved in the regulation of the sleep/waking cycle and normal sleep architectonics and is crucial for the performance of a variety of somatomotor, vital autonomic, oculomotor, vestibular, auditory, ingestive and somatosensory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76aed15ea62878282b109b64bc537b6
https://hdl.handle.net/11370/d556c2f4-3217-4c83-bb70-ef83d4e85531
https://hdl.handle.net/11370/d556c2f4-3217-4c83-bb70-ef83d4e85531