Identification of androgen-selective androgen-response elements in the human aquaporin-5 and Rad9 genes

Autor: Udo Moehren, Sarah Denayer, Guy Verrijdt, Michael Podvinec, Frank Claessens

Publikováno v: Biochemical Journal. 411:679-686

The AR (androgen receptor) is known to influence the expression of its target genes by binding to different sets of AREs (androgen-response elements) in the DNA. One set consists of the classical steroid-response elements which are partial palindromi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e054a0f4a07bcbc7c80196ec193f840f
https://doi.org/10.1042/bj20071352

Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model

Autor: Udo Moehren, Guy Verrijdt, Leen Callewaert, Kris Schauwaers, Karel De Gendt, Guido Verhoeven, Philippa T. K. Saunders, Johannes V. Swinnen, Annemie Haelens, Frank Claessens, Nina Atanassova

Publikováno v: Proceedings of the National Academy of Sciences. 104:4961-4966

Androgens influence transcription of their target genes through the activation of the androgen receptor (AR) that subsequently interacts with specific DNA motifs in these genes. These DNA motifs, called androgen response elements (AREs), can be class

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8c27d7c2a380a8a7364e7139fb2cf4
https://doi.org/10.1073/pnas.0610814104

The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor Alien

Autor: Christina A. Reeb, Sami Väisänen, Aria Baniahmad, Udo Moehren, Thomas W. Dunlop, Uwe Dressel, Carsten Carlberg

Publikováno v: Nucleic Acids Research. 32:2995-3004

The Sin3 proteins are evolutionarily conserved co-repressors (CoR) that function as mediators of gene repression for a variety of transcriptional silencers. The paired amphipathic helices of Sin3A were identified and studied as protein–protein inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc7d4ce4350a41ec334d8fee216f919
https://doi.org/10.1093/nar/gkh621

The Amino Terminus of the Human AR Is Target for Corepressor Action and Antihormone Agonism

Autor: Helmut Dotzlaw, Aria Baniahmad, Andrew C.B. Cato, Udo Moehren, Jorge A Iñiguez Lluhí, Sigrun Mink

Publikováno v: Molecular Endocrinology. 16:661-673

Antiandrogens inhibit the ligand-induced transactivation by the androgen receptor (AR) and have a widespread use in the treatment of prostate cancer but their mode of action is not fully understood. Here we show that the ability of the antiandrogen c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64feb5cd301a97635200e566e62f3ed1
https://doi.org/10.1210/mend.16.4.0798

Wild-type but not mutant androgen receptor inhibits expression of the hTERT telomerase subunit: a novel role of AR mutation for prostate cancer development

Autor: Simona Nanni, Annalisa Grasselli, Udo Moehren, Mohammad Asim, Aria Baniahmad, Christina A. Reeb, Ina Prade, Antonella Farsetti, Daniela Roell, Maria Papaioannou

Publikováno v: The FASEB journal 22(4) (2008): 1258–1267.
info:cnr-pdr/source/autori:Moehren U; Papaioannou M; Reeb CA; Grasselli A; Nanni S; Asim M; Roell D; Prade I; Farsetti A; Baniahmad A./titolo:Wild-type but not mutant androgen receptor inhibits expression of the hTERT telomerase subunit: a novel role of AR mutation for prostate cancer development/doi:/rivista:The FASEB journal/anno:2008/pagina_da:1258/pagina_a:1267/intervallo_pagine:1258–1267/volume:22(4)

Androgens play a central role in prostate development and prostate cancer proliferation. Induction of telomerase is an early event in prostate carcinogenesis and is considered as a marker for both primary tumors and metastases. Interestingly, several

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b27e9f5a68962b038daf934ad12269
https://pubmed.ncbi.nlm.nih.gov/17991730