Zobrazeno 1 - 10
of 310
pro vyhledávání: '"Udo Heinemann"'
Autor:
Sebastian Proft, Janna Leiz, Udo Heinemann, Dominik Seelow, Kai M. Schmidt-Ott, Maria Rutkiewicz
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background Transcription factors regulate gene expression by binding to transcription factor binding sites (TFBSs). Most models for predicting TFBSs are based on position weight matrices (PWMs), which require a specific motif to be present i
Externí odkaz:
https://doaj.org/article/28fe24eb9a574b1bb3d2d16dfad99c28
Autor:
Anup Arumughan, Yvette Roske, Carolin Barth, Laura Lleras Forero, Kenny Bravo-Rodriguez, Alexandra Redel, Simona Kostova, Erik McShane, Robert Opitz, Katja Faelber, Kirstin Rau, Thorsten Mielke, Oliver Daumke, Matthias Selbach, Elsa Sanchez-Garcia, Oliver Rocks, Daniela Panáková, Udo Heinemann, Erich E. Wanker
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The AAA+ ATPase p97 is an essential hexameric protein with multiple protein interaction partners and cellular functions. Here, the authors use interaction mapping to examine partner proteins of this large complex, and assess the effects of these prot
Externí odkaz:
https://doaj.org/article/c05c3467f02d4df0b4320632445b06fa
Autor:
Udo Heinemann, Yvette Roske
Publikováno v:
Symmetry, Vol 12, Iss 5, p 737 (2020)
In nature and in the test tube, nucleic acids occur in many different forms. Apart from single-stranded, coiled molecules, DNA and RNA prefer to form helical arrangements, in which the bases are stacked to shield their hydrophobic surfaces and expose
Externí odkaz:
https://doaj.org/article/230708de2b7943ef98237bc6b4744b65
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e8991 (2010)
Armadillo (ARM) repeat proteins function in various cellular processes including vesicular transport and membrane tethering. They contain an imperfect repeating sequence motif that forms a conserved three-dimensional structure. Recently, structural a
Externí odkaz:
https://doaj.org/article/2d83cb8592b4432bb5de5c0f31b96efc
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4656 (2009)
The golgin family gives identity and structure to the Golgi apparatus and is part of a complex protein network at the Golgi membrane. The golgin p115 is targeted by the GTPase Rab1a, contains a large globular head region and a long region of coiled-c
Externí odkaz:
https://doaj.org/article/1e2f35b261774061b9dfd2a53e4c25e3
Autor:
Yvette Roske, Florian Lindemann, Anne Diehl, Nils Cremer, Victoria A. Higman, Brigitte Schlegel, Martina Leidert, Kristina Driller, Kürşad Turgay, Peter Schmieder, Udo Heinemann, Hartmut Oschkinat
Studying mechanisms of bacterial biofilm generation is of vital importance to understanding bacterial cell–cell communication, multicellular cohabitation principles, and the higher resilience of microorganisms in a biofilm against antibiotics. Biof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0560e45104429c88ad0d3842f6349cce
http://edoc.mdc-berlin.de/23281/2/23281suppl.pdf
http://edoc.mdc-berlin.de/23281/2/23281suppl.pdf
Publikováno v:
Medizinische Genetik. 33:147-155
Transcription factors (TFs) bind DNA in a sequence-specific manner and thereby regulate target gene expression. TF binding and its regulatory activity is highly context dependent, and is not only determined by specific cell types or differentiation s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42d32d722660b209b825c04f1c9b5b1
https://doi.org/10.1515/medgen-2021-2073
https://doi.org/10.1515/medgen-2021-2073
Autor:
Edgar Specker, Susann Matthes, Radoslaw Wesolowski, Anja Schütz, Maik Grohmann, Natalia Alenina, Dirk Pleimes, Keven Mallow, Martin Neuenschwander, Angelina Gogolin, Marie Weise, Jochen Pfeifer, Nandor Ziebart, Udo Heinemann, Jens Peter von Kries, Marc Nazaré, Michael Bader
Publikováno v:
Journal of medicinal chemistry. 65(16)
Tryptophan hydroxylases catalyze the first and rate-limiting step in the synthesis of serotonin. Serotonin is a key neurotransmitter in the central nervous system and, in the periphery, functions as a local hormone with multiple physiological functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e842003cab36ae4837912e90d8329e4
https://pubmed.ncbi.nlm.nih.gov/35921615
https://pubmed.ncbi.nlm.nih.gov/35921615
Autor:
Kai Schmidt-Ott, Maria Rutkiewicz, Dominik Seelow, Janna Leiz, Sebastian Proft, Udo Heinemann
Transcription factors regulate gene expression by binding to transcription factor binding sites (TFBSs). Most models for predicting TFBSs are based on position weight matrices (PWMs), which require a specific motif to be present in the DNA sequence a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::426c178867c597093024305fdf6e97e7
https://doi.org/10.1101/2022.06.28.497553
https://doi.org/10.1101/2022.06.28.497553
Autor:
Sandra Miksche, Nandor Ziebart, Yelena Mostinski, Judith de Schryver, Sylvia Oestreich, Christoph Rademacher, Yuliya Kolomeets, Martin Neuenschwander, Walter Birchmeier, Carola Seyffarth, Silke Radetzki, María P. López-Alberca, Guus J.J.E. Heynen, Jens Peter von Kries, Marc Nazaré, Elena Shanina, Yvette Roske, Jerome Paul, David Schaller, Andrea Volkamer, Udo Heinemann
Publikováno v:
Journal of Medicinal Chemistry. 63:14780-14804
The tyrosine phosphatase SHP2 controls the activity of pivotal signaling pathways, including MAPK, JAK-STAT, and PI3K-Akt. Aberrant SHP2 activity leads to uncontrolled cell proliferation, tumorigenesis, and metastasis. SHP2 signaling was recently lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0e872dcac1cd82c94170d19f6ce653
https://doi.org/10.1021/acs.jmedchem.0c01265
https://doi.org/10.1021/acs.jmedchem.0c01265