Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Udo Gräfe"'
Publikováno v:
Biotechnology letters. 9(12)
The reductive cleavage of the aclacinomycins A (I), Y (II), and B (III) by intact mycelia or subcellular fractions of the producer strain S. spec. AM 33352/F43 is suppressed in the presence of uncouplers, complex-forming agents, detergents, and some
Publikováno v:
Zeitschrift für allgemeine Mikrobiologie. 13:115-129
The activities of some NADP-specific enzymes and of corresponding metabolic pathways were studied in mycelium extracts of Streptomyces hygroscopicus JA 6599 strains producing different yields of the macrolide antibiotic A 6599. Isocitrate dehydrogena
Publikováno v:
Zeitschrift für allgemeine Mikrobiologie. 15:249-257
The possible role of some metabolic systems producing acetyl-CoA, malonyl-CoA, and methylmalonyl-CoA as initial precursors in the biosynthesis of the macrolide antibiotic A 6599 by Streptomyces hygroscopicus JA 6599 was studied. The activities of pyr
Publikováno v:
The Journal of Antibiotics. 58:356-360
Three sterol-type compounds (compounds 4, 5 and 6) were isolated from culture broth of pathogenic Nocardia otitidiscaviarum IFM 0988 and Amycolatopsis sp. IFM 0703 strains which were isolated from Japanese patients. The structures of the compounds we
Autor:
Pavel A. Grigoriev, Albrecht Berg, Matthias Kronen, Udo Gräfe, Brigitte Schlegel, Albert Härtl
Publikováno v:
Journal of Peptide Science. 9:763-768
The efficiencies of membrane pore formation by 14 naturally occurring peptaibols and two structurally modified ampullosporins were compared using an artificial bilayer membrane model. Major differences were found in the dependence on peptide sequence
Autor:
Thomas Degenkolb, Albrecht Berg, Albert Härtl, Pavel A. Grigoriev, Brigitte Schlegel, Torsten Neuhof, Udo Gräfe
Publikováno v:
Journal of Peptide Science. 9:810-816
Trichofumins A-D were isolated from cultures of Trichoderma sp. HKI 0276 as new 11 and 13mer peptaibols. Similar to 15mer peptaibols they promote morphogenesis of the fungus Phoma destructiva and cause hypothermia in mice as a characteristic of neuro
Autor:
Siegmund Reißmann, Martin Bohl, Matthias Kronen, Hoai-Huong Nguyen, Helmar Görls, Udo Gräfe, Jürgen Sühnel
Publikováno v:
Journal of Peptide Science. 9:729-744
Ampullosporin A is a 15-mer peptaibol type polypeptide that induces pigment formation by the fungus Phoma destructiva, forms voltage-dependent ion channels in membranes and exhibits hypothermic effects in mice. The structure of ampullosporin A has be
Publikováno v:
Journal of Peptide Science. 9:666-678
Peptaibols and related peptide antibiotics (peptaibiotics) display diagnostically useful fragmentation patterns during mass spectrometry (FAB-MS, ESI-CID-MS/MS and CID-MSn]. The paper compiles fragmentation data of pseudo-molecular ions reported in t
Publikováno v:
Journal of Peptide Science. 9:714-728
Ampullosporin A (AmpA), a 15mer peptalbol containing seven Aib residues is able to induce pigmentation on Phoma destructiva and hypothermia in mice, as well as to exhibit a neuroleptic effect. A circular dichroism study of ampullosporin A and its ana
Autor:
Winfried Schumann, Walter Werner, Lothar Heinisch, Peter Jütten, Albert Härtl, Hermann Ulbricht, Udo Gräfe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1339-1342
Madurahydroxylactone (MHL) is a secondary metabolite produced by the soil bacterium Nonomuria rubra and belongs to the family of benzo[ a ]naphthacenequinones. We report the initial results and structure–activity relationships of our study into a s