Zobrazeno 1 - 10
of 327
pro vyhledávání: '"Udo Oppermann"'
Autor:
Chao-Hui Chang, Feng Liu, Stefania Militi, Svenja Hester, Reshma Nibhani, Siwei Deng, James Dunford, Aniko Rendek, Zahir Soonawalla, Roman Fischer, Udo Oppermann, Siim Pauklin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-29 (2024)
Abstract The lethality, chemoresistance and metastatic characteristics of cancers are associated with phenotypically plastic cancer stem cells (CSCs). How the non-cell autonomous signalling pathways and cell-autonomous transcriptional machinery orche
Externí odkaz:
https://doaj.org/article/2125cb9f886147e3b057aef73e84507f
Autor:
Elizabeth J. Brown, Leire Balaguer-Lluna, Adam P. Cribbs, Martin Philpott, Leticia Campo, Molly Browne, Jong Fu Wong, Udo Oppermann, Ángel M. Carcaboso, Alex N. Bullock, Gillian Farnie
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract H3K27-altered Diffuse Midline Glioma (DMG) is a universally fatal paediatric brainstem tumour. The prevalent driver mutation H3K27M creates a unique epigenetic landscape that may also establish therapeutic vulnerabilities to epigenetic inhib
Externí odkaz:
https://doaj.org/article/cd300eaf757540c2bae8198462204942
Autor:
Mai Abdel Mouti, Siwei Deng, Martin Pook, Jessica Malzahn, Aniko Rendek, Stefania Militi, Reshma Nibhani, Zahir Soonawalla, Udo Oppermann, Chang-il Hwang, Siim Pauklin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Pancreatic cancer (PC), one of the most aggressive and life-threatening human malignancies, is known for its resistance to cytotoxic therapies. This is increasingly ascribed to the subpopulation of undifferentiated cells, known as pancreatic
Externí odkaz:
https://doaj.org/article/e03882910170417599161aa3b318306e
Autor:
Gaurav Agarwal, Sally Moore, Ross Sadler, Sherin Varghese, Alison Turner, Lucia Y Chen, Jemma Larham, Nathanael Gray, Oluremi Carty, Joe Barrett, Constantinos Koshiaris, Jaimal Kothari, Stella Bowcock, Udo Oppermann, Vicky Gamble, Gordon Cook, Chara Kyriakou, Mark Drayson, Supratik Basu, Sarah McDonald, Shelagh McKinley, Sarah Gooding, Muhammad K Javaid, Karthik Ramasamy
Publikováno v:
Haematologica, Vol 109, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/52cad2ba691f42a2abc69921f2c09c66
Autor:
Keiji Kurata, Anna-James Bott, Mark A. Tye, Leona Yamamoto, Mehmet K. Samur, Yu-Tzu Tai, James Dunford, Catrine Johansson, Filiz Senbabaoglu, Martin Philpott, Charlotte Palmer, Karthik Ramasamy, Sarah Gooding, Mihaela Smilova, Giorgia Gaeta, Manman Guo, John C. Christianson, N. Connor Payne, Kritika Singh, Kubra Karagoz, Matthew E. Stokes, Maria Ortiz, Patrick Hagner, Anjan Thakurta, Adam Cribbs, Ralph Mazitschek, Teru Hideshima, Kenneth C. Anderson, Udo Oppermann
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Multiple myeloma (MM) is a plasma cell malignancy characterised by aberrant production of immunoglobulins requiring survival mechanisms to adapt to proteotoxic stress. We here show that glutamyl-prolyl-tRNA synthetase (GluProRS) inhibition c
Externí odkaz:
https://doaj.org/article/9a68487f85794fbbb8d94c8c96041cdb
Autor:
Simge Kelekci, Anna Riedel, Dieter Weichenhan, Ashish Goyal, Katherine Kelly, Marion Baehr, Birgitta Michels, Cindy Koerner, Irene Orzella, James Dunford, Pavlo Lutsik, Stefan Wiemann, Udo Oppermann, Christoph Plass
Publikováno v:
HemaSphere, Vol 7, p e688561e (2023)
Externí odkaz:
https://doaj.org/article/bab11af04da34c338b67a6176e890cae
Autor:
Mark A. Tye, N. Connor Payne, Catrine Johansson, Kritika Singh, Sofia A. Santos, Lọla Fagbami, Akansha Pant, Kayla Sylvester, Madeline R. Luth, Sofia Marques, Malcolm Whitman, Maria M. Mota, Elizabeth A. Winzeler, Amanda K. Lukens, Emily R. Derbyshire, Udo Oppermann, Dyann F. Wirth, Ralph Mazitschek
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The development of antimalarials against the human liver and asexual blood stages is one of the top public health challenges. Here, the authors report a single-step biochemical assay for the characterization of prolyl-tRNA synthetase inhibitors, and
Externí odkaz:
https://doaj.org/article/67e7e347e61b426e9ad816c4a19d8f56
Autor:
Alison Dickson, Eylan Yutuc, Catherine A. Thornton, James E. Dunford, Udo Oppermann, Yuqin Wang, William J. Griffiths
Publikováno v:
Open Biology, Vol 13, Iss 5 (2023)
Most biologically active oxysterols have a 3β-hydroxy-5-ene function in the ring system with an additional site of oxidation at C-7 or on the side-chain. In blood plasma oxysterols with a 7α-hydroxy group are also observed with the alternative 3-ox
Externí odkaz:
https://doaj.org/article/17d9e78ab32f4d83adb33f794fb2752d
Autor:
Deniz Uğurlu-Çimen, Deniz Odluyurt, Kenan Sevinç, Nazlı Ezgi Özkan-Küçük, Burcu Özçimen, Deniz Demirtaş, Eray Enüstün, Can Aztekin, Martin Philpott, Udo Oppermann, Nurhan Özlü, Tamer T. Önder
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-13 (2021)
Abstract Background The histone H3 lysine 79 (H3K79) methyltransferase DOT1L is a key chromatin-based barrier to somatic cell reprogramming. However, the mechanisms by which DOT1L safeguards cell identity and somatic-specific transcriptional programs
Externí odkaz:
https://doaj.org/article/6c418758198f4fd28da489c60812d32b
Autor:
Matt Lechner, Volker H. Schartinger, Christopher D. Steele, Wen Long Nei, Marc Lucas Ooft, Liesa-Marie Schreiber, Christodoulos P. Pipinikas, Grace Tin-Yun Chung, Yuk Yu Chan, Feng Wu, Ka-Fai To, Chi Man Tsang, Wayne Pearce, Daniele Morelli, Martin Philpott, Liam Masterson, Reshma Nibhani, Graham Wells, Christopher G. Bell, Julia Koller, Susanne Delecluse, Yim Ling Yip, Jacklyn Liu, Cillian T. Forde, Martin D. Forster, Amrita Jay, József Dudás, Annika Krapp, Simon Wan, Christian Uprimny, Susanne Sprung, Johannes Haybaeck, Tim R. Fenton, Kerry Chester, Christina Thirlwell, Gary Royle, Teresa Marafioti, Rajeev Gupta, Sagung Rai Indrasari, Camelia Herdini, Mohd Afiq Mohd Slim, I. Indrawati, Liam Sutton, Renske Fles, Bing Tan, Joe Yeong, Amit Jain, Shuting Han, Haitao Wang, Kelvin S. H. Loke, Wan He, Ruilian Xu, Hongtao Jin, Zhiqiang Cheng, David Howard, Peter H. Hwang, Quynh-Thu Le, Joshua K. Tay, Robert B. West, Sai Wah Tsao, Tim Meyer, Herbert Riechelmann, Udo Oppermann, Henri-Jacques Delecluse, Stefan M. Willems, Melvin L. K. Chua, Pierre Busson, Kwok Wai Lo, Guido Wollmann, Nischalan Pillay, Bart Vanhaesebroeck, Valerie J. Lund
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nasopharyngeal carcinoma (NPC) lacks effective diagnostic and therapeutic strategies, in particular at advanced stages. Here, the authors show that expression of the somatostatin receptor 2 is induced by Epstein-Barr virus in NPC and has a key role i
Externí odkaz:
https://doaj.org/article/ff5d4bfec0f74e349a04c2a36d9baae8