Zobrazeno 1 - 10 of 127 pro vyhledávání: '"Udhaya Kumar S"'
1
Akademický článek
Structure-Based Virtual Screening to Identify Novel Potential Compound as an Alternative to Remdesivir to Overcome the RdRp Protein Mutations in SARS-CoV-2
Autor: Thirumal Kumar D, Nishaat Shaikh, Udhaya Kumar S, George Priya Doss C, Hatem Zayed
Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)
The number of confirmed COVID-19 cases is rapidly increasing with no direct treatment for the disease. Few repurposed drugs, such as Remdesivir, Chloroquine, Hydroxychloroquine, Lopinavir, and Ritonavir, are being tested against SARS-CoV-2. Remdesivi
Externí odkaz: https://doaj.org/article/3675f5522c7e4c88a14f6ce04eb2e02b
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2
Akademický článek
Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach
Autor: Udhaya Kumar S., Srivarshini Sankar, Salma Younes, Thirumal Kumar D., Muneera Naseer Ahmad, Sarah Samer Okashah, Balu Kamaraj, Abeer Mohammed Al-Subaie, George Priya Doss C., Hatem Zayed
Publikováno v: Molecules, Vol 25, Iss 23, p 5543 (2020)
Filamins (FLN) are a family of actin-binding proteins involved in regulating the cytoskeleton and signaling phenomenon by developing a network with F-actin and FLN-binding partners. The FLN family comprises three conserved isoforms in mammals: FLNA,
Externí odkaz: https://doaj.org/article/93fc2ad66485452382db11ef9eced360
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4
Akademický článek
Identification of Potential Inhibitors Targeting GTPase-Kirsten RAt Sarcoma Virus (K-Ras) Driven Cancers via E-Pharmacophore-Based Virtual Screening and Drug Repurposing Approach
Autor: Udhaya Kumar. S, Rinku Polachirakkal Varghese, V. Anu Preethi, C. George Priya Doss, Hatem Zayed
Publikováno v: Frontiers in Bioscience-Landmark, Vol 28, Iss 11, p 288 (2023)
Background: Mutations in the K-Ras gene are among the most frequent genetic alterations in various cancers, and inhibiting RAS signaling has shown promising results in treating solid tumors. However, finding effective drugs that can bind to the RAS p
Externí odkaz: https://doaj.org/article/c701843aee914ff095058feb7f4bb032
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6
Effects of the pathological E200K mutation on human prion protein: A computational screening and molecular dynamics approach
Autor: Fatemeh Rahimi Gharemirshamloo, Ranabir Majumder, Udhaya Kumar S., George Priya Doss C., Kourosh Bamdad, Fateme Frootan, Cemal Un
Publikováno v: Journal of Cellular Biochemistry. 124:254-265
The human prion protein gene (PRNP) is mapped to the short arm of chromosome 20 (20pter-12). Prion disease is associated with mutations in the prion protein-encoding gene sequence. Earlier studies found that the mutation G127V in the PRNP increases p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059ffa0dba242263fe80abccc6aac563
https://doi.org/10.1002/jcb.30359
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8
Identification of potential inhibitors, conformational dynamics, and mechanistic insights into mutant Kirsten rat sarcoma virus (G13D) driven cancers
Autor: Iftikhar A. Tayubi, Udhaya Kumar S., George Priya Doss C.
Publikováno v: Journal of Cellular Biochemistry. 123:1467-1480
The mutations at the hotspot region of K-Ras result in the progression of cancer types. Our study aimed to explore the small molecule inhibitors against the G13D mutant K-Ras model with anti-cancerous activity from food and drug administration (FDA)-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f58f63094c5770b9f7c919ddc9c2789
https://doi.org/10.1002/jcb.30305
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10
Exome sequence analysis of rare frequency variants in Late-Onset Alzheimer Disease
Autor: Sudharsana Sundarrajan, Arthi Venkatesan, Udhaya Kumar S, Mohanraj Gopikrishnan, Iftikhar Aslam Tayubi, M Aditya, Gowrishankar Bychapur Siddaiah, C. George Priya Doss, Hatem Zayed
Publikováno v: Metabolic Brain Disease.
Alzheimer disease (AD) is a leading cause of dementia in elderly patients who continue to live between 3 and 11 years of diagnosis. A steep rise in AD incidents is observed in the elderly population in East-Asian countries. The disease progresses thr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad60965d0378daddf10ca090a926890b
https://doi.org/10.1007/s11011-023-01221-7
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