Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Uddhav Timilsina"'
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012330 (2024)
Membrane-associated RING-CH (MARCH) 2 is a member of the MARCH protein family of RING-CH finger E3 ubiquitin ligases that play important roles in regulating the levels of proteins found on the cell surface. MARCH1, 2 and 8 inhibit HIV-1 infection by
Externí odkaz:
https://doaj.org/article/b64e4f9d1bc140449b570cfae28f3da2
Autor:
Uddhav Timilsina, Emily B. Ivey, Sean Duffy, Arnon Plianchaisuk, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Jumpei Ito, Kei Sato, Spyridon Stavrou
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2351 (2024)
A feature of the SARS-CoV-2 Omicron subvariants BF.5 and BF.7 that recently circulated mainly in China and Japan was the high prevalence of the ORF7a: H47Y mutation, in which the 47th residue of ORF7a has been mutated from a histidine (H) to a tyrosi
Externí odkaz:
https://doaj.org/article/2e3eeb09fb9445ec8bf93d6426456d78
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
SERINC5, is a cellular multipass transmembrane protein involved in sphingolipid and phosphatydilserine biogenesis and a known retroviral restriction factor. Here, Timilsina et al. show that SERINC5 is a host restriction factor for SARS-CoV-2 that pre
Externí odkaz:
https://doaj.org/article/6c2597e68f2e4a9cbb0f8dad7c3e6670
Autor:
Uddhav Timilsina, Spyridon Stavrou
Publikováno v:
PLoS Pathogens, Vol 19, Iss 1, p e1011076 (2023)
Externí odkaz:
https://doaj.org/article/8ab3320c022d4de8ae9e9804d5de700f
A single G10T polymorphism in HIV-1 subtype C Gag-SP1 regulates sensitivity to maturation inhibitors
Publikováno v:
Retrovirology, Vol 18, Iss 1, Pp 1-18 (2021)
Abstract Background Maturation inhibitors (MIs) potently block HIV-1 maturation by inhibiting the cleavage of the capsid protein and spacer peptide 1 (CA-SP1). Bevirimat (BVM), a highly efficacious first-in-class MI against HIV-1 subtype B isolates,
Externí odkaz:
https://doaj.org/article/5f37a1ea91794a46bbc06c01e2763d89
Autor:
Supawadee Umthong, Brian Lynch, Uddhav Timilsina, Brandon Waxman, Emily B. Ivey, Spyridon Stavrou
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
This study examines the mechanism utilized by different MARCH proteins to restrict retrovirus infection. MARCH proteins block the incorporation of envelope glycoproteins to the budding virions.
Externí odkaz:
https://doaj.org/article/07cc78778e8143c1913ec13e206a415c
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT The serine incorporator (SERINC) proteins are multipass transmembrane proteins that affect sphingolipid and phosphatidylserine synthesis. Human SERINC5 and SERINC3 were recently shown to possess antiretroviral activity for a number of retrov
Externí odkaz:
https://doaj.org/article/1fa53f40c492410dbb3ae3dbd4f6f788
Autor:
Gorakh Raj Giri, Uddhav Timilsina
Publikováno v:
Nepal Journal of Biotechnology, Vol 5, Iss 1, Pp 46-57 (2017)
Apoptosis is a form of programmed cell death leading to genetically controlled self-destruction of cells. It is essential in the development, maintenance, and regulation of cells during physiological as well as pathological conditions. Deregulation o
Externí odkaz:
https://doaj.org/article/edbcf7f5746c4f8b93589d4e8ff406ec
Autor:
Gorakh Raj Giri, Uddhav Timilsina
Publikováno v:
Nepal Journal of Biotechnology, Vol 5, Iss 1 (2017)
Externí odkaz:
https://doaj.org/article/83b95d465ef94e73849b419637775e0a
Autor:
Hem K Tamang, Uddhav Timilsina, Khelanand P Singh, Sanjit Shrestha, Bishal Pandey, Sameer Basnet, Binod Waiba, Umang Shrestha
Publikováno v:
Indian Journal of Endocrinology and Metabolism, Vol 17, Iss 7, Pp 349-354 (2013)
Objective: Adiponectin- one of the most important adipokines plays a pivotal role in carbohydrate and lipid metabolism and vascular biology. Changing food trend and lifestyle has tremendously affected the health status of Nepalese population. Studies
Externí odkaz:
https://doaj.org/article/a3bd0d5c5fc54161a27e4117c705ab6e