HIV Skews a Balanced Mtb-Specific Th17 Response in Latent Tuberculosis Subjects to a Pro-inflammatory Profile Independent of Viral Load.

Autor: Rakshit S; Laboratory of Immunology of HIV-TB Co-infection, Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, India., Hingankar N; Laboratory of Immunology of HIV-TB Co-infection, Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, India., Alampalli SV; Laboratory of Immunology of HIV-TB Co-infection, Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, India., Adiga V; Laboratory of Immunology of HIV-TB Co-infection, Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, India., Sundararaj BK; Laboratory of Immunology of HIV-TB Co-infection, Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, India., Sahoo PN; Laboratory of Immunology of HIV-TB Co-infection, Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, India., Finak G; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Uday Kumar J AJ; Departments of Infectious Diseases & Pulmonary Medicine, St. John's Research Institute, Bangalore, India., Dhar C; Departments of Infectious Diseases & Pulmonary Medicine, St. John's Research Institute, Bangalore, India., D'Souza G; Departments of Infectious Diseases & Pulmonary Medicine, St. John's Research Institute, Bangalore, India., Virkar RG; National Aids Research Institute, Bhosari, Pune, Maharashtra, India., Ghate M; National Aids Research Institute, Bhosari, Pune, Maharashtra, India., Thakar MR; National Aids Research Institute, Bhosari, Pune, Maharashtra, India., Paranjape RS; National Aids Research Institute, Bhosari, Pune, Maharashtra, India., De Rosa SC; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Ottenhoff THM; Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands., Vyakarnam A; Laboratory of Immunology of HIV-TB Co-infection, Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, India; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, Faculty of Life Sciences & Medicine, Guy's Hospital, King's College London, London SE1 9RT, UK. Electronic address: anna.vyakarnam@kcl.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2020 Dec 01; Vol. 33 (9), pp. 108451.