Výsledky vyhledávání - "Uday Kompella"

Akademický článek

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

Autor: Ju-Hyun Lee, Mary Kate McBrayer, Devin M. Wolfe, Luke J. Haslett, Asok Kumar, Yutaka Sato, Pearl P.Y. Lie, Panaiyur Mohan, Erin E. Coffey, Uday Kompella, Claire H. Mitchell, Emyr Lloyd-Evans, Ralph A. Nixon

Publikováno v: Cell Reports, Vol 12, Iss 9, Pp 1430-1444 (2015)

Presenilin 1 (PS1) deletion or Alzheimer’s disease (AD)-linked mutations disrupt lysosomal acidification and proteolysis, which inhibits autophagy. Here, we establish that this phenotype stems from impaired glycosylation and instability of vATPase

Externí odkaz: https://doaj.org/article/4b67173bf3dc4cc4a3ad2615020ddeb6

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Akademický článek

Modifier genes as therapeutics: the nuclear hormone receptor Rev Erb alpha (Nr1d1) rescues Nr2e3 associated retinal disease.

Autor: Nelly M Cruz, Yang Yuan, Barrett D Leehy, Rinku Baid, Uday Kompella, Margaret M DeAngelis, Pascal Escher, Neena B Haider

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e87942 (2014)

Nuclear hormone receptors play a major role in many important biological processes. Most nuclear hormone receptors are ubiquitously expressed and regulate processes such as metabolism, circadian function, and development. They function in these proce

Externí odkaz: https://doaj.org/article/741461758d294881b8e6a4309c5ff2c2

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