Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Udai S. Kammula"'
Autor:
Shravan Leonard-Murali, Chetana Bhaskarla, Ghanshyam S. Yadav, Sudeep K. Maurya, Chenna R. Galiveti, Joshua A. Tobin, Rachel J. Kann, Eishan Ashwat, Patrick S. Murphy, Anish B. Chakka, Vishal Soman, Paul G. Cantalupo, Xinming Zhuo, Gopi Vyas, Dara L. Kozak, Lindsey M. Kelly, Ed Smith, Uma R. Chandran, Yen-Michael S. Hsu, Udai S. Kammula
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Immune checkpoint inhibition has shown success in treating metastatic cutaneous melanoma but has limited efficacy against metastatic uveal melanoma, a rare variant arising from the immune privileged eye. To better understand this resistance,
Externí odkaz:
https://doaj.org/article/c3827bd8a22341ebb07936043ec06ea7
Autor:
Esther Giehl, Hiromichi Kosaka, Zuqiang Liu, Mathilde Feist, Udai S. Kammula, Michael T. Lotze, Congrong Ma, Zong Sheng Guo, David L. Bartlett
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Adoptive cell therapy (ACT) using autologous tumor infiltrating lymphocytes (TIL) achieves durable clinical benefit for patients from whom these cells can be derived in advanced metastatic melanoma but is limited in most solid tumors as a result of i
Externí odkaz:
https://doaj.org/article/525f6f107eda4fd488a555127d5b674c
Autor:
Rajeev Dhupar, Olugbenga T. Okusanya, Seth H. Eisenberg, Sara E. Monaco, Ayana T. Ruffin, Dongyan Liu, James D. Luketich, Udai S. Kammula, Tullia C. Bruno, Michael T. Lotze, Adam C. Soloff
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6178 (2020)
While T cell-based cancer immunotherapies have shown great promise, there remains a need to understand how individual metastatic tumor environments impart local T cell dysfunction. At advanced stages, cancers that metastasize to the pleural space can
Externí odkaz:
https://doaj.org/article/d4fe496bc79f4217bedf59a18c6739d8
Autor:
Steven A. Rosenberg, James C. Yang, Nicholas P. Restifo, Sid P. Kerkar, Mary Ann Toomey, Steven A. Feldman, Udai S. Kammula, Marybeth S. Hughes, Giao Q. Phan, Richard M. Sherry, Lien T. Ngo, Azam V. Nahvi, Sadik H. Kassim, Mark E. Dudley, Zhili Zheng, Joal D. Beane, Richard A. Morgan, Ling Zhang
Supplemental figure 2. Phenotype of NFAT.IL12 gene modified TIL compared to matched untransduced TIL.Shown are the percentage of cells with a phenotype consistent with effector memory (CD62L-CD45RA-),central memory (CD62L+CD45RA-), Naive (CD62+, CD45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b62ad53dd29f0fe028259344ccc6ef
https://doi.org/10.1158/1078-0432.22457129.v1
https://doi.org/10.1158/1078-0432.22457129.v1
Autor:
Udai S. Kammula, Manjula Kasoji, Parthav Jailwala, Mark Raffeld, Trinh H. Pham, Liqiang Xi, Chyi-Chia R. Lee, John R. Wunderlich, Robert Somerville, Abhishek K. Srivastava, Biman C. Paria, Smita S. Chandran, Daniel J. Stephens, Arvind C. Sabesan, Luke D. Rothermel
Purpose: Uveal melanoma is a rare melanoma variant with no effective therapies once metastases develop. Although durable cancer regression can be achieved in metastatic cutaneous melanoma with immunotherapies that augment naturally existing antitumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65326c7a03b2154ace93cd1ac8ac2106
https://doi.org/10.1158/1078-0432.c.6523679
https://doi.org/10.1158/1078-0432.c.6523679
Autor:
Udai S. Kammula, Steven A. Rosenberg, Francesco M. Marincola, Daniel J. Stephens, Donald E. White, John R. Wunderlich, Seth M. Steinberg, Andrea Abati, Armando C. Filie, Patricia A. Fetsch, Edmund K. Bartlett
Purpose: Metastasis heterogeneity presents a significant obstacle to the development of targeted cancer therapeutics. In this study, we sought to establish from a large series of human melanoma metastases whether there exists a determined pattern in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ab918b312ca9f4e66bb75f61a8f236
https://doi.org/10.1158/1078-0432.c.6521519.v1
https://doi.org/10.1158/1078-0432.c.6521519.v1
Autor:
Steven A. Rosenberg, Mona El-Gamil, Yong F. Li, Chyi-Chia R. Lee, Mark Raffeld, Nicholas P. Restifo, Marybeth S. Hughes, Udai S. Kammula, Richard M. Sherry, John R. Wunderlich, Mark E. Dudley, James C. Yang, Steven A. Feldman, Richard A. Morgan, Jessica S. Crystal, Thai L.N. Tran, Sadik H. Kassim, Paul F. Robbins
Purpose: Although adoptive cell therapy can be highly effective for the treatment of patients with melanoma, the application of this approach to the treatment of other solid tumors has been limited. The observation that the cancer germline (CG) antig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630a85db2fc034bced91a4aed33233ba
https://doi.org/10.1158/1078-0432.c.6524657.v1
https://doi.org/10.1158/1078-0432.c.6524657.v1
Autor:
Udai S. Kammula, Steven A. Rosenberg, Francesco M. Marincola, Daniel J. Stephens, Donald E. White, John R. Wunderlich, Seth M. Steinberg, Andrea Abati, Armando C. Filie, Patricia A. Fetsch, Edmund K. Bartlett
PDF file - 51K, Pairwise comparison of antigen expression by individual anatomic site cluster. Shown are p value results of Cochran-Armitage test for trend. p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3540dc544c4b7e9aa69699f84a4a24c6
https://doi.org/10.1158/1078-0432.22448930.v1
https://doi.org/10.1158/1078-0432.22448930.v1
Autor:
Steven A. Rosenberg, Mona El-Gamil, Yong F. Li, Chyi-Chia R. Lee, Mark Raffeld, Nicholas P. Restifo, Marybeth S. Hughes, Udai S. Kammula, Richard M. Sherry, John R. Wunderlich, Mark E. Dudley, James C. Yang, Steven A. Feldman, Richard A. Morgan, Jessica S. Crystal, Thai L.N. Tran, Sadik H. Kassim, Paul F. Robbins
Legends for Supplementary Figures 1 and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368914cc972a3a957a3c1494e3df97e9
https://doi.org/10.1158/1078-0432.22460963.v1
https://doi.org/10.1158/1078-0432.22460963.v1
Autor:
Steven A. Rosenberg, James C. Yang, Nicholas P. Restifo, Sid P. Kerkar, Mary Ann Toomey, Steven A. Feldman, Udai S. Kammula, Marybeth S. Hughes, Giao Q. Phan, Richard M. Sherry, Lien T. Ngo, Azam V. Nahvi, Sadik H. Kassim, Mark E. Dudley, Zhili Zheng, Joal D. Beane, Richard A. Morgan, Ling Zhang
Supplemental figure 4. IL6 and IL10 levels. Shown are data from five patients with elevated IL12 and IFNg levels that were subject to cytokine multiplex analysis. Only cytokine IL6 and IL10 were shown to be consistently elevated post-infusion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e695baf815b4bc7224d3617847ff746
https://doi.org/10.1158/1078-0432.22457123.v1
https://doi.org/10.1158/1078-0432.22457123.v1