Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Ucheor B Choi"'
Autor:
Stijn van Dorp, Ruoyi Qiu, Ucheor B Choi, Minnie M Wu, Michelle Yen, Michael Kirmiz, Axel T Brunger, Richard S Lewis
Publikováno v:
eLife, Vol 10 (2021)
The dimeric ER Ca2+ sensor STIM1 controls store-operated Ca2+ entry (SOCE) through the regulated binding of its CRAC activation domain (CAD) to Orai channels in the plasma membrane. In resting cells, the STIM1 CC1 domain interacts with CAD to suppres
Externí odkaz:
https://doaj.org/article/562008a665714d11b73e5baf3ccafc7b
Publikováno v:
eLife, Vol 7 (2018)
The recycling of SNARE proteins following complex formation and membrane fusion is an essential process in eukaryotic trafficking. A highly conserved AAA+ protein, NSF (N-ethylmaleimide sensitive factor) and an adaptor protein, SNAP (soluble NSF atta
Externí odkaz:
https://doaj.org/article/16de592c06514366be70c0596def7c4f
Autor:
Ucheor B Choi, Minglei Zhao, K Ian White, Richard A Pfuetzner, Luis Esquivies, Qiangjun Zhou, Axel T Brunger
Publikováno v:
eLife, Vol 7 (2018)
SNARE complex disassembly by the ATPase NSF is essential for neurotransmitter release and other membrane trafficking processes. We developed a single-molecule FRET assay to monitor repeated rounds of NSF-mediated disassembly and reassembly of individ
Externí odkaz:
https://doaj.org/article/b6ef30140f2c4082a52d6af39cbdac0b
Publikováno v:
eLife, Vol 5 (2016)
Complexin regulates spontaneous and activates Ca2+-triggered neurotransmitter release, yet the molecular mechanisms are still unclear. Here we performed single molecule fluorescence resonance energy transfer experiments and uncovered two conformation
Externí odkaz:
https://doaj.org/article/3dbe4dc50d8a46e1a78f3401e9f63e31
Autor:
Claire Gething, Joshua Ferrar, Bishal Misra, Giovanni Howells, Alexa L. Andrzejewski, Mark E. Bowen, Ucheor B. Choi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Neurotransmitter release of synaptic vesicles relies on the assembly of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, consisting of syntaxin and SNAP-25 on the plasma membrane and synaptobrevin on
Externí odkaz:
https://doaj.org/article/6e2c5e0cbefc46f081bc7fe8575d0dbd
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 4 (2022)
The N-methyl-D-aspartate (NMDA)-sensitive glutamate receptor (NMDAR) helps assemble downstream signaling pathways through protein interactions within the postsynaptic density (PSD), which are mediated by its intracellular C-terminal domain (CTD). The
Externí odkaz:
https://doaj.org/article/9454e398600446aebeb30b3542a7e84e
Publikováno v:
Biomolecules, Vol 9, Iss 3, p 114 (2019)
The common conception of intrinsically disordered proteins (IDPs) is that they stochastically sample all possible configurations driven by thermal fluctuations. This is certainly true for many IDPs, which behave as swollen random coils that can be de
Externí odkaz:
https://doaj.org/article/1b34f0c11b554205a4e40afd25b57251
Autor:
Ruoyi Qiu, Stijn van Dorp, Axel T. Brunger, Ucheor B. Choi, Richard S. Lewis, Michelle Yen, Minnie M. Wu, Michael Kirmiz
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The dimeric ER Ca2+ sensor STIM1 controls store-operated Ca2+ entry (SOCE) through the regulated binding of its CRAC activation domain (CAD) to Orai channels in the plasma membrane. In resting cells, the STIM1 CC1 domain interacts with CAD to suppres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7108d2ada7e98ccf796eb324466c6bc6
https://elifesciences.org/articles/66194
https://elifesciences.org/articles/66194
Autor:
Claire Gething, Richard A. Pfuetzner, Giovanni Howells, Ucheor B. Choi, Holland Matlock, Axel T. Brunger, Luis Esquivies, Bishal Misra, Katie Dunleavy
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8106d8e28f4f7d1d2a6270160655fd7b
https://doi.org/10.1096/fasebj.2021.35.s1.03481
https://doi.org/10.1096/fasebj.2021.35.s1.03481