Výsledky vyhledávání - "Ubiratan Moura"

Data from Role of Hedgehog Signaling in Malignant Pleural Mesothelioma

Autor: Emanuela Felley-Bosco, Rolf A. Stahel, Walter Weder, Svenja Thies, Hubert Rehrauer, Alex Soltermann, Isabelle Opitz, Ubiratan Moura, Yandong Shi

Purpose: The aim of this study was to assess the activity of hedgehog signaling pathway in malignant pleural mesothelioma (MPM).Experimental Design: The expression of hedgehog signaling components was assessed by quantitative PCR and in situ hybridiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e08347f82f4ea2d48208e8dcbea02e
https://doi.org/10.1158/1078-0432.c.6522537

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Supplementary Figure 1 from Role of Hedgehog Signaling in Malignant Pleural Mesothelioma

Autor: Emanuela Felley-Bosco, Rolf A. Stahel, Walter Weder, Svenja Thies, Hubert Rehrauer, Alex Soltermann, Isabelle Opitz, Ubiratan Moura, Yandong Shi

PDF file, 96K, 1A. Expression of HH pathway components in non-tumoral pleural tissue and mesothelioma tumors. Quantitative real-time PCR analysis of SMO, GLI2, IHH, DHH gene expression in non-tumoral pleural tissue (NT) and tumor (T). 1B. Overall sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1957dad271e52e22190af0a36395f5c6
https://doi.org/10.1158/1078-0432.22452672

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Supplementary Figure 5 from Role of Hedgehog Signaling in Malignant Pleural Mesothelioma

Autor: Emanuela Felley-Bosco, Rolf A. Stahel, Walter Weder, Svenja Thies, Hubert Rehrauer, Alex Soltermann, Isabelle Opitz, Ubiratan Moura, Yandong Shi

PDF file, 50K, GLI1 transfection (GLI1) leads to increased expression of GLI1 target HHIP compared to control vector (V) transfected ZL55SPT cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6166835aa32097679949f66858d234f2
https://doi.org/10.1158/1078-0432.22452660.v1

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Supplementary Figure 6 from Role of Hedgehog Signaling in Malignant Pleural Mesothelioma

Autor: Emanuela Felley-Bosco, Rolf A. Stahel, Walter Weder, Svenja Thies, Hubert Rehrauer, Alex Soltermann, Isabelle Opitz, Ubiratan Moura, Yandong Shi

PDF file, 66K, Western blot analysis of NF2 protein in SDM103T, ZL55SPT cells. SDM71 cells were used as positive control (1). 1. Thurneysen C, Opitz I, Kurtz S, Weder W, Stahel RA, Felley-Bosco E. Functional inactivation of NF2/merlin in human mesoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bea95bba97848a5a4af23f5d121f3af
https://doi.org/10.1158/1078-0432.22452657.v1

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Supplementary Figure 2 from Role of Hedgehog Signaling in Malignant Pleural Mesothelioma

Autor: Emanuela Felley-Bosco, Rolf A. Stahel, Walter Weder, Svenja Thies, Hubert Rehrauer, Alex Soltermann, Isabelle Opitz, Ubiratan Moura, Yandong Shi

PDF file, 60K, MPM primary cultures maintained without serum in 3% oxygen show a three-fold increase in expression of ABCG2, GLI1 and PATCH1 compared to cultures without serum in 20% oxygen.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b985064795ea002a65cd436c976bd96
https://doi.org/10.1158/1078-0432.22452669

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Supplementary Methods and Table 1 from Role of Hedgehog Signaling in Malignant Pleural Mesothelioma

Autor: Emanuela Felley-Bosco, Rolf A. Stahel, Walter Weder, Svenja Thies, Hubert Rehrauer, Alex Soltermann, Isabelle Opitz, Ubiratan Moura, Yandong Shi

PDF file, 36K, Table S1: Primers used for RT-PCR.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014341ac28301bf7ab1e0434a8f47296
https://doi.org/10.1158/1078-0432.22452651

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Supplementary Figure 7 from Role of Hedgehog Signaling in Malignant Pleural Mesothelioma

Autor: Emanuela Felley-Bosco, Rolf A. Stahel, Walter Weder, Svenja Thies, Hubert Rehrauer, Alex Soltermann, Isabelle Opitz, Ubiratan Moura, Yandong Shi

PDF file, 159K, HHIP protein is expressed in all tumor cells and its levels are increased by HhAntag. Immunohistochemistry analysis of HHIP expression was performed on xenograft tumors of control and HhAntag treated mice. H score was determined based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b81113abe6c3770724179d492b8d0a
https://doi.org/10.1158/1078-0432.22452654

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Role of Hedgehog Signaling in Malignant Pleural Mesothelioma

Autor: Isabelle Opitz, Walter Weder, Ubiratan Moura, Svenja Thies, Yandong Shi, Hubert Rehrauer, Rolf A. Stahel, Emanuela Felley-Bosco, Alex Soltermann

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research

Purpose: The aim of this study was to assess the activity of hedgehog signaling pathway in malignant pleural mesothelioma (MPM). Experimental Design: The expression of hedgehog signaling components was assessed by quantitative PCR and in situ hybridi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934e7528aa8b1d9ebf4d265c3b49a8b5
https://doi.org/10.1158/1078-0432.ccr-12-0599

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Inhibition of phosphoinositide-3 kinase pathway down regulates ABCG2 function and sensitizes malignant pleural mesothelioma to chemotherapy

Autor: Bruno Fischer, Rolf A. Stahel, Emanuela Felley-Bosco, Claudia Frei, Ubiratan Moura

Malignant pleural mesothelioma (MPM) is a relatively chemoresistant malignancy. Diverse biological targets are under investigation to develop new therapeutic options. One of these targets, namely the phosphoinositide-3-kinase (PI3K) pathway, has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94effda469ad2c3ef22ff3b2051eece9
https://doi.org/10.5167/uzh-76818

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