ISG15 deficiency and increased viral resistance in humans but not mice

Autor: Zhi Li, Benhur Lee, Ilhan Tezcan, Payam Tabarsi, Sofija Buta, Nahal Mansouri, Frederic Vigant, Domenico Tortorella, James Duehr, Béatrice Payelle-Brogard, Sandra Pellegrini, Li Qian, Scott D. Speer, Véronique Francois-Newton, Davood Mansouri, Jacob Piehler, Alexander N. Freiberg, Mark Hermann, Thomas J. Gardner, Marisela R. Rodriguez, Ozden Sanal, Tim Wedeking, Adolfo García-Sastre, Coralie F. Daussy, Deborah J. Lenschow, Erminia Rubino, Dusan Bogunovic

Publikováno v: Nature communications, vol. 7, pp. 11496
Nature Communications
Nature Communications, Nature Publishing Group, 2016, 7, pp.11496. ⟨10.1038/ncomms11496⟩
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications, 2016, 7, pp.11496. ⟨10.1038/ncomms11496⟩

ISG15 is an interferon (IFN)-α/β-induced ubiquitin-like protein. It exists as a free molecule, intracellularly and extracellularly, and conjugated to target proteins. Studies in mice have demonstrated a role for Isg15 in antiviral immunity. By cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e5d1fd4382cc5fb25eff02fa341fa9
https://serval.unil.ch/resource/serval:BIB_8158D3B3AE00.P001/REF.pdf

The de novo synthesis of ubiquitin: Identification of deubiquitinases acting on ubiquitin precursors

Autor: Jorge E. Azevedo, Manuel P. Pinto, Cláudia P. Grou, Andreia V. Mendes, Pedro Domingues

Publikováno v: Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Protein ubiquitination, a major post-translational modification in eukaryotes, requires an adequate pool of free ubiquitin. Cells maintain this pool by two pathways, both involving deubiquitinases (DUBs): recycling of ubiquitin from ubiquitin conjuga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88c7208f50f47172e6fd0e46a582ae1
https://repositorio-aberto.up.pt/handle/10216/117908

Explorative genetic study of UBQLN2 and PFN1 in an extended Flanders-Belgian cohort of frontotemporal lobar degeneration patients

Autor: Ivailo Tournev, Marc Cruts, Tim Van Langenhove, Julie van der Zee, Mathieu Vandenbulcke, Lubina Dillen, Patrick Cras, Rik Vandenberghe, Peter Paul De Deyn, Sebastiaan Engelborghs, Céline Merlin, Christine Van Broeckhoven, Albena Jordanova, Stayko Sarafov

Publikováno v: Neurobiology of aging
Neurobiology of Aging, 34(6):ARTN 1711.e1. ELSEVIER SCIENCE INC

UBQLN2 and PFN1 were recently associated with amyotrophic lateral sclerosis (ALS). We investigated a role for these ALS genes in frontotemporal lobar degeneration (FTLD). We screened 328 FTLD, 17 FTLD-ALS, and 157 ALS patients. Patients originated fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d540e22844a45cf9ff3538596a7660
https://doi.org/10.1016/j.neurobiolaging.2012.12.007