Zobrazeno 1 - 10
of 18 076
pro vyhledávání: '"Ubiquitin-Conjugating Enzymes"'
Autor:
Taylor JD; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK. jonathan.taylor@astrazeneca.com., Barrett N; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Martinez Cuesta S; Data Sciences and Quantitative Biology, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Cambridge, CB2 0AA, UK., Cassidy K; Protein Sciences, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Waltham, MA, 02451, USA., Pachl F; Protein Sciences, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Waltham, MA, 02451, USA., Dodgson J; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Patel R; Centre for Genomics Research, Dynamic Omics, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Cambridge, CB2 0AA, UK., Eriksson TM; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Riley A; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Burrell M; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Bauer C; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Rees DG; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Cimbro R; Centre for Genomics Research, Dynamic Omics, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Cambridge, CB2 0AA, UK., Zhang AX; Protein Sciences, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Waltham, MA, 02451, USA., Minter RR; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Hunt J; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK. james.hunt1@astrazeneca.com., Legg S; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK.
Publikováno v:
Communications biology [Commun Biol] 2024 Sep 19; Vol. 7 (1), pp. 1179. Date of Electronic Publication: 2024 Sep 19.
Autor:
Du, Xiaodi1 (AUTHOR), Hua, Ruiqi1 (AUTHOR), He, Xue1 (AUTHOR), Hou, Wei2 (AUTHOR), Li, Shengqiong2 (AUTHOR), Yang, Aiguo2 (AUTHOR) aiguoyang163@163.com, Yang, Guangyou1 (AUTHOR) guangyou1963@126.com
Publikováno v:
Parasites & Vectors. 4/20/2024, Vol. 17 Issue 1, p1-13. 13p.
Autor:
Jonathan D. Taylor, Nathalie Barrett, Sergio Martinez Cuesta, Katelyn Cassidy, Fiona Pachl, James Dodgson, Radhika Patel, Tuula M. Eriksson, Aidan Riley, Matthew Burrell, Christin Bauer, D. Gareth Rees, Raffaello Cimbro, Andrew X. Zhang, Ralph R. Minter, James Hunt, Sandrine Legg
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Proteins can be targeted for degradation by engineering biomolecules that direct them to the eukaryotic ubiquitination machinery. For instance, the fusion of an E3 ubiquitin ligase to a suitable target binding domain creates a ‘biological
Externí odkaz:
https://doaj.org/article/82c3864e38134c29b42485f93454e6e6
Autor:
Yan W; Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Zhong Y; Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Hu X; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Xu T; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Zhang Y; Center for Innovative Biomedical Resources, Biosensor Core, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Kales S; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Qu Y; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Talley DC; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Baljinnyam B; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., LeClair CA; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Simeonov A; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Polster BM; Department of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Huang R; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Ye Y; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Rai G; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Henderson MJ; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Tao D; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA. dingyin.tao@nih.gov., Fang S; Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. sfang@som.umaryland.edu.; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. sfang@som.umaryland.edu.; Program in Oncology, UM Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. sfang@som.umaryland.edu.
Publikováno v:
Nature communications [Nat Commun] 2023 Aug 09; Vol. 14 (1), pp. 4798. Date of Electronic Publication: 2023 Aug 09.
Autor:
Wang, Sheng1,2 (AUTHOR), Cao, Ling2 (AUTHOR), Willick, Ian R.1 (AUTHOR), Wang, Hong2 (AUTHOR) hong.wang@usask.ca, Tanino, Karen K.1 (AUTHOR) hong.wang@usask.ca
Publikováno v:
International Journal of Molecular Sciences. Oct2022, Vol. 23 Issue 19, p11143. 21p.
Autor:
Critchley WR; Endothelial Cell Biology Unit, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Smith GA; Endothelial Cell Biology Unit, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Zachary IC; Centre for Cardiovascular Biology & Medicine, Rayne Building, University College London, London WC1E 6JF, UK., Harrison MA; School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK., Ponnambalam S; Endothelial Cell Biology Unit, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
Publikováno v:
Journal of cell science [J Cell Sci] 2023 May 15; Vol. 136 (10). Date of Electronic Publication: 2023 May 25.
Autor:
Wang Y; Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Key Clinical Laboratory of Henan Province, Zhengzhou, China., Ma Q; Department of Neurosurgery, Peking University Third Hospital, Peking University, Beijing, China., Li H; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China., Huang W; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.; Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, Changsha, China., You J; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China., Liu D; Department of Lymphoma and Abdominal Radiotherapy, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Publikováno v:
Molecular carcinogenesis [Mol Carcinog] 2024 Oct; Vol. 63 (10), pp. 1967-1979. Date of Electronic Publication: 2024 Jul 17.
Akademický článek
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Autor:
Lv, Peng1,2 (AUTHOR), Liu, Jihong1,2 (AUTHOR) jhliu@tjh.tjmu.edu.cn, Liu, Xiaming1,2 (AUTHOR) xmliu77@hust.edu.cn
Publikováno v:
Reproductive Biology & Endocrinology. 8/28/2024, Vol. 22 Issue 1, p1-11. 11p.
Autor:
Hayashida R; Ubiquitin Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Kikuchi R; Ubiquitin Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Biomolecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan., Imai K; Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan., Kojima W; Ubiquitin Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Biomolecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan., Yamada T; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Iijima M; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Sesaki H; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Tanaka K; Protein Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan., Matsuda N; Ubiquitin Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Biomolecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: nr-matsuda.biom@tmd.ac.jp., Yamano K; Ubiquitin Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Biomolecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: kojibiom@tmd.ac.jp.
Publikováno v:
The Journal of biological chemistry [J Biol Chem] 2023 Feb; Vol. 299 (2), pp. 102822. Date of Electronic Publication: 2022 Dec 21.