Zobrazeno 1 - 10
of 7 942
pro vyhledávání: '"Ubiquitin Proteasome System"'
Autor:
Zeng H, Geng X, Wan H, Qu X, Tang S, Zhang R, Zhou M, Yu Z, Pan J, Zheng H, Zhu Y, Huang S, Huang D
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 10397-10419 (2024)
Hong Zeng,1,2,* Xitong Geng,2,* Hao Wan,3,* Xiaoyu Qu,2 Shengwei Tang,2 Ruiyu Zhang,3 Minqin Zhou,2 Zichuan Yu,2 Jingying Pan,3 Hao Zheng,2 Yanting Zhu,2 Shuhan Huang,2 Da Huang1 1Department of Thyroid Surgery, Second Affiliated Hospital
Externí odkaz:
https://doaj.org/article/fce52363b62a40009fb971c78ebc8366
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 5615-5639 (2024)
Chunyan Weng,1,* Rijuan Jin,1,* Xiaoliang Jin,1,* Zimei Yang,1,* Chenghai He,1,2 Qiuhua Zhang,1 Jingli Xu,1,3 Bin Lv1 1Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Prov
Externí odkaz:
https://doaj.org/article/aafe34663c9f41f28eabffa1e2ea0689
Autor:
Michal Zigo, Jacob Netherton, Natálie Zelenková, Karl Kerns, Veronika Kraus, Pavla Postlerová, Mark Baker, Peter Sutovsky
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Capacitation is an essential post-testicular maturation event endowing spermatozoa with fertilizing capacity within the female reproductive tract, significant for fertility, reproductive health, and contraception. By using a human-relevant l
Externí odkaz:
https://doaj.org/article/0ff92330ca3d4b5398908bbe077259fb
Autor:
M. A. Zakharova, M. V. Chudinov
Publikováno v:
Тонкие химические технологии, Vol 19, Iss 3, Pp 214-231 (2024)
Objectives. To describe the pharmaceutical technology of controlled degradation of protein molecules (PROTAC®, Proteolysis Targeting Chimera), approaches to the design of the PROTAC® molecule, methods of ligand and linker selection and synthesis, a
Externí odkaz:
https://doaj.org/article/ada0adb00df44d4e8dbe708ae2f25183
Autor:
Eva Žerovnik
Publikováno v:
Exploration of Neuroscience, Vol 3, Iss 4, Pp 295-308 (2024)
A short overview of the main features of progressive myoclonus epilepsies (PMEs), such as Lafora disease (LD), neuronal ceroid lipofuscinoses (NCLs), and myoclonus epilepsy with ragged-red fibers (MERRF) is given. The stress of this review paper is p
Externí odkaz:
https://doaj.org/article/52cef95ae4d64d248c63a622a864e528
Autor:
Alireza Zangooie, Shima Tavoosi, Mahan Arabhosseini, Aram Halimi, Helia Zangooie, Amir Hossein Baghsheikhi, Soheila Rahgozar, Mohammad Ahmadvand, Alireza Mosavi Jarrahi, Zahra Salehi
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Leukemia, a type of blood cell cancer, is categorized by the type of white blood cells affected (lymphocytes or myeloid cells) and disease progression (acute or chronic). In 2020, it ranked 15th among the most diagnosed cancers an
Externí odkaz:
https://doaj.org/article/a03ca13de0b240f6ac9f62ddb2e82125
Autor:
Mateusz K. Hołda, Urszula Raźny, Maria Sordyl, Joanna Góralska, Maria Kapusta, Krystyna Słowińska-Solnica, Dorota Wojtysiak, Grzegorz Lis, Bogdan Solnica, Grzegorz Kopeć, Jakub Hołda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The goal of this study was to evaluate the intensity of autophagy and ubiquitin-dependent proteolysis processes occurring in myocardium of left ventricle (LV) in subsequent stages of pulmonary arterial hypertension (PAH) to determine mechani
Externí odkaz:
https://doaj.org/article/21456b46ab024a68a0b53be2609dad44
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Background Immunoregulatory drugs regulate the ubiquitin-proteasome system, which is the main treatment for multiple myeloma (MM) at present. In this study, bioinformatics analysis was used to construct the risk model and evaluate the progno
Externí odkaz:
https://doaj.org/article/63e219387c564502b57fe3a85c403e81
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundMalaria is a devasting parasitic disease that causes over half a million deaths every year. The necessity for prompt and thorough antimalarial drug discovery and development is accelerated by the rise in multidrug resistance and the lack of
Externí odkaz:
https://doaj.org/article/ae59986c63b24013928c85031955f481
Publikováno v:
Genes and Diseases, Vol 11, Iss 5, Pp 101150- (2024)
The advent of tyrosine kinase inhibitors (TKI) targeting BCR-ABL has drastically changed the treatment approach of chronic myeloid leukemia (CML), greatly prolonged the life of CML patients, and improved their prognosis. However, TKI resistance is st
Externí odkaz:
https://doaj.org/article/7cfec49cead04316911cebf15dc34f7c