Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Ubiquitin B"'
Publikováno v:
Cancer Nanotechnology, Vol 13, Iss 1, Pp 1-14 (2022)
Abstract Objective RNA interference holds tremendous potential in the treatment of malignant tumors. However, efficient and biocompatible delivery methods are needed for systemic delivery of small interfering RNA (siRNA). In this study, we explored t
Externí odkaz:
https://doaj.org/article/5d356b83b1bb4cf7ba7048438c3975cf
Publikováno v:
Aging (Albany NY)
UBB+1 is a mutated version of ubiquitin B peptide caused by a transcriptional frameshift due to the RNA polymerase II "slippage". The accumulation of UBB+1 has been linked to ubiquitin-proteasome system (UPS) dysfunction and neurodegeneration. Alzhei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f83d4a8ee9972f77c5149f532ac90f
http://europepmc.org/articles/PMC8610117
http://europepmc.org/articles/PMC8610117
Autor:
Ana María Sifuentes-Rincón, Williams Arellano-Vera, Francisco Alejandro Paredes-Sánchez, Felipe Alonso Rodríguez Almeida, Elsa Verónica Herrera-Mayorga, Daniel Trejo-Martínez
Publikováno v:
Revista Mexicana de Ciencias Pecuarias. 11:894-904
Reproduction is a key element in cattle production systems. Systems biology approaches, including those involving gene networks, have been applied to genetic dissection complex phenotypes in cattle. A set of 385 genes associated with reproductive tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c93e67434470396638eb84a22ed23e55
https://doi.org/10.22319/rmcp.v11i3.5279
https://doi.org/10.22319/rmcp.v11i3.5279
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Qing Liu, Yuexin Hu, Xiao Li, Xin Nie, Juanjuan Liu, Rui Gou, Bei Lin, Mingjun Zheng, Jing Wang
Publikováno v:
Aging (Albany NY)
In this study, we identified prognostic biomarkers in ovarian carcinoma by integrating multi-omics DNA copy number variation (CNV) and methylation variation (MET) data. CNV, MET, and messenger RNA (mRNA) expression were examined in 351 ovarian carcin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ec8921c379ee0c80cd04e8950637a9
https://doi.org/10.18632/aging.102047
https://doi.org/10.18632/aging.102047
Autor:
Feng-Yuan Zhang, Shun-Xing Zhu, Xing Su, Xiao-Xiao Han, Songlin Zhou, Chao-Lun Dai, Bin Yu, Xing-Mei Feng, Rong-Hua Wu, Huimin Xie, Yan Li
Publikováno v:
Neural Regeneration Research
Neural Regeneration Research, Vol 17, Iss 3, Pp 608-617 (2022)
Neural Regeneration Research, Vol 17, Iss 3, Pp 608-617 (2022)
Glial cells play an important role in signal transduction, energy metabolism, extracellular ion homeostasis and neuroprotection of the central nervous system. However, few studies have explained the potential effects of exosomes from glial cells on c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e0a523c0d01eef6dc7a9644d49af8e
https://doi.org/10.4103/1673-5374.320999
https://doi.org/10.4103/1673-5374.320999
Autor:
William C. Forrester, Alexia T. Kedves, Quang-Dé Nguyen, Dennis M. Bonal, Sneha Sanghavi, Prafulla C. Gokhale, Elizabeth George, Fred Harbinski, Robert J. Distel, Paul Kirschmeier, Scott Gleim, Michael S. Goldberg, Christina Benander, Xiaoyou Liang, Jeremy L. Jenkins, Frederic Sigoillot
Publikováno v:
Journal of Clinical Investigation. 127:4554-4568
Transcriptional repression of ubiquitin B (UBB) is a cancer-subtype-specific alteration that occurs in a substantial population of patients with cancers of the female reproductive tract. UBB is 1 of 2 genes encoding for ubiquitin as a polyprotein con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d190d88b06e78c55a0435fa13b13fe74
https://doi.org/10.1172/jci92914
https://doi.org/10.1172/jci92914
Autor:
Yanping Zhang, Qin Qian, Tang Jingdong, Gan Shujie, Lei Zhang, Miao Zheng, Yiwen Feng, Wan Zhong
Publikováno v:
Molecular Medicine Reports
The present study aimed to identify the involvement of critical genes in systemic vasculitis, to gain an improved understanding of the molecular circuity and to investigate novel potential gene targets for systemic vasculitis treatment. The dual-colo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5368b365186ca409dbc47b2c6dfa4f5f
http://europepmc.org/articles/PMC5436278
http://europepmc.org/articles/PMC5436278
Publikováno v:
Experimental eye research. 181
Pseudoexfoliation (PEX), an ocular disorder involving deposition of proteinaceous fibrils on the surface of anterior eye tissues, is a major contributing factor to worldwide glaucoma. Excessive production and accumulation of fibrillar materials in PE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d8ca4487619f7d0cb136cc27c3e312
https://pubmed.ncbi.nlm.nih.gov/30738879
https://pubmed.ncbi.nlm.nih.gov/30738879
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
The ubiquitin-proteasome system (UPS) is the main pathway responsible for the degradation of misfolded proteins, and its dysregulation has been implicated in several neurodegenerative diseases, including Alzheimer's disease (AD). UBB+1, a mutant vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0d2d19b79cdbaf7c8bfd5c6758d7c9
https://www.frontiersin.org/article/10.3389/fnmol.2018.00200/full
https://www.frontiersin.org/article/10.3389/fnmol.2018.00200/full