Zobrazeno 1 - 10
of 12 362
pro vyhledávání: '"Ubiquitin–proteasome"'
Autor:
Mamata Chaudhari, Igor Zelko, Pawel Lorkiewicz, David Hoetker, Yibing Nong, Benjamin Doelling, Kenneth Brittian, Aruni Bhatnagar, Sanjay Srivastava, Shahid P. Baba
Publikováno v:
Skeletal Muscle, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Muscle wasting is a serious complication in heart failure patients. Oxidative stress and inflammation are implicated in the pathogenesis of muscle wasting. Oxidative stress leads to the formation of toxic lipid peroxidation products, such as
Externí odkaz:
https://doaj.org/article/e219c85edc9c4286b5285ba0bdfb315e
Autor:
Yalan Li, Xiaoyue Chen, Yiqing Xiong, Xueqiang Xu, Caidie Xie, Min Min, Dongmei Liang, Cheng Chen, Huijuan Mao
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background The prevalence of vascular calcification (VC) in chronic kidney disease (CKD) patients remains substantial, but currently, there are no effective pharmaceutical therapies available. BRCA1/BRCA2-containing complex subunit 36 (BRCC3
Externí odkaz:
https://doaj.org/article/c02d71d0f79247c9a7b30b57fc94fc2a
Autor:
Michal Zigo, Jacob Netherton, Natálie Zelenková, Karl Kerns, Veronika Kraus, Pavla Postlerová, Mark Baker, Peter Sutovsky
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Capacitation is an essential post-testicular maturation event endowing spermatozoa with fertilizing capacity within the female reproductive tract, significant for fertility, reproductive health, and contraception. By using a human-relevant l
Externí odkaz:
https://doaj.org/article/0ff92330ca3d4b5398908bbe077259fb
Autor:
M. A. Zakharova, M. V. Chudinov
Publikováno v:
Тонкие химические технологии, Vol 19, Iss 3, Pp 214-231 (2024)
Objectives. To describe the pharmaceutical technology of controlled degradation of protein molecules (PROTAC®, Proteolysis Targeting Chimera), approaches to the design of the PROTAC® molecule, methods of ligand and linker selection and synthesis, a
Externí odkaz:
https://doaj.org/article/ada0adb00df44d4e8dbe708ae2f25183
Autor:
Eva Žerovnik
Publikováno v:
Exploration of Neuroscience, Vol 3, Iss 4, Pp 295-308 (2024)
A short overview of the main features of progressive myoclonus epilepsies (PMEs), such as Lafora disease (LD), neuronal ceroid lipofuscinoses (NCLs), and myoclonus epilepsy with ragged-red fibers (MERRF) is given. The stress of this review paper is p
Externí odkaz:
https://doaj.org/article/52cef95ae4d64d248c63a622a864e528
Autor:
Alireza Zangooie, Shima Tavoosi, Mahan Arabhosseini, Aram Halimi, Helia Zangooie, Amir Hossein Baghsheikhi, Soheila Rahgozar, Mohammad Ahmadvand, Alireza Mosavi Jarrahi, Zahra Salehi
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Leukemia, a type of blood cell cancer, is categorized by the type of white blood cells affected (lymphocytes or myeloid cells) and disease progression (acute or chronic). In 2020, it ranked 15th among the most diagnosed cancers an
Externí odkaz:
https://doaj.org/article/a03ca13de0b240f6ac9f62ddb2e82125
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-38 (2024)
Abstract Skeletal muscular atrophy is a complex disease involving a large number of gene expression regulatory networks and various biological processes. Despite extensive research on this topic, its underlying mechanisms remain elusive, and effectiv
Externí odkaz:
https://doaj.org/article/c80163b6580c4e64a59321be85db6405
Autor:
Mateusz K. Hołda, Urszula Raźny, Maria Sordyl, Joanna Góralska, Maria Kapusta, Krystyna Słowińska-Solnica, Dorota Wojtysiak, Grzegorz Lis, Bogdan Solnica, Grzegorz Kopeć, Jakub Hołda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The goal of this study was to evaluate the intensity of autophagy and ubiquitin-dependent proteolysis processes occurring in myocardium of left ventricle (LV) in subsequent stages of pulmonary arterial hypertension (PAH) to determine mechani
Externí odkaz:
https://doaj.org/article/21456b46ab024a68a0b53be2609dad44
Autor:
Shuang Zhao, Jie Li, Songqi Duan, Chang Liu, Hua Wang, Jiangtao Lu, Nannan Zhao, Xiaoyan Sheng, Yiwei wu, Yanjun Li, Baofa Sun, Lin Liu
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background Telomeres consist of repetitive DNA sequences at the chromosome ends to protect chromosomal stability, and primarily maintained by telomerase or occasionally by alternative telomere lengthening of telomeres (ALT) through recombina
Externí odkaz:
https://doaj.org/article/3420e738ce6c4ec28a26af31cf2620db
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Background Immunoregulatory drugs regulate the ubiquitin-proteasome system, which is the main treatment for multiple myeloma (MM) at present. In this study, bioinformatics analysis was used to construct the risk model and evaluate the progno
Externí odkaz:
https://doaj.org/article/63e219387c564502b57fe3a85c403e81