Výsledky vyhledávání - "Ubaldina Galli"

Akademický článek

Biochemical and structural analysis of a cytosolic sulfotransferase of the malaria vector Anopheles gambiae overexpressed in the reproductive tissues

Autor: Arianna Esposito Verza, Riccardo Miggiano, Fabrizio Lombardo, Carmine Fiorillo, Bruno Arcà, Beatrice Purghé, Erika Del Grosso, Ubaldina Galli, Menico Rizzi, Franca Rossi

Publikováno v: Current Research in Structural Biology, Vol 4, Iss , Pp 246-255 (2022)

The temporary or permanent chemical modification of biomolecules is a crucial aspect in the physiology of all living species. However, while some modules are well characterised also in insects, others did not receive the same attention. This holds tr

Externí odkaz: https://doaj.org/article/612717f95e7641e588e678c52fe124bc

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Akademický článek

Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy

Autor: Ubaldina Galli, Giorgia Colombo, Cristina Travelli, Gian Cesare Tron, Armando A. Genazzani, Ambra A. Grolla

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

Nicotinamide adenine dinucleotide (NAD) is a cofactor of many enzymatic reactions as well as being a substrate for a number of NAD-consuming enzymes (e.g., PARPS, sirtuins, etc). NAD can be synthesized de novo starting from tryptophan, nicotinamide,

Externí odkaz: https://doaj.org/article/533060d51ac24f429b4a5ccc95a3118e

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Akademický článek

The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors

Autor: Ubaldina Galli, Elisa Ciraolo, Alberto Massarotti, Jean Piero Margaria, Giovanni Sorba, Emilio Hirsch, Gian Cesare Tron

Publikováno v: Molecules, Vol 20, Iss 9, Pp 17275-17287 (2015)

A novel series of 4-aryl-3-cyano-2-(3-hydroxyphenyl)-6-morpholino-pyridines have been designed as potential phosphatidylinositol-3-kinase (PI3K) inhibitors. The compounds have been synthesized using the Guareschi reaction to prepare the key 4-aryl-3-

Externí odkaz: https://doaj.org/article/1dfbdea40a17481daa4a4048c493dcaf

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Akademický článek

α-Amino Acids as Synthons in the Ugi-5-Centers-4-Components Reaction: Chemistry and Applications

Autor: Sveva Pelliccia, Ilenia Antonella Alfano, Ubaldina Galli, Ettore Novellino, Mariateresa Giustiniano, Gian Cesare Tron

Publikováno v: Symmetry, Vol 11, Iss 6, p 798 (2019)

Since the first reports, the Ugi four-component reaction (U-4CR) has been recognized as a keystone transformation enabling the synthesis of peptide mimetics in a single step and with high atom economy. In recent decades, the U-4CR has been a source o

Externí odkaz: https://doaj.org/article/24e4d7debaea43458cc114365ac9f873

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Akademický článek

Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines

Autor: Ubaldina Galli, Rejdia Hysenlika, Fiorella Meneghetti, Erika Del Grosso, Sveva Pelliccia, Ettore Novellino, Mariateresa Giustiniano, Gian Cesare Tron

Publikováno v: Molecules, Vol 24, Iss 10, p 1959 (2019)

A novel one-pot multicomponent reaction to synthesize substituted imidazopyrazines is described. In brief, 1H-(imidazol-5-yl)-N-substituted methanamines react with aldehydes and isocyanides in methanol at room temperature to give imidazopyrazine deri

Externí odkaz: https://doaj.org/article/fce0afb0b42b4862a0cc7d777f609113

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Data from Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells

Autor: Antonio Sica, Armando A. Genazzani, Mario P. Colombo, Claudio Tripodo, Vincenzo Bronte, Stefano Ugel, Rosalinda Trovato, Massimiliano Mazzone, Tiziana Pressiani, Lorenza Rimassa, Paola Portararo, Gian Cesare Tron, Ubaldina Galli, Ambra A. Grolla, Sara Morlacchi, Mariangela Storto, Sabina Sangaletti, Francesca Maria Consonni, Cristina Travelli

Cancer induces alteration of hematopoiesis to fuel disease progression. We report that in tumor-bearing mice the macrophage colony-stimulating factor elevates the myeloid cell levels of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limitin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87b8ab8c814b72bcf9692fb74e41a5c1
https://doi.org/10.1158/0008-5472.c.6511605.v1

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Figure S1 from Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells

NAMPT inhibitors reduce both tumor growth and MDSCs expansion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b1e81fc9844fc5d387212b7fbd130e
https://doi.org/10.1158/0008-5472.22423914

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Identification of novel aza-analogs of TN-16 as disrupters of microtubule dynamics through a multicomponent reaction

Autor: Arash Foroutan, Marco Corazzari, Ambra A. Grolla, Giorgia Colombo, Cristina Travelli, Armando A. Genazzani, Sewan Theeramunkong, Ubaldina Galli, Gian Cesare Tron

Publikováno v: European journal of medicinal chemistry. 245(Pt 1)

Despite novel biological targets emerging at an impressive rate for anticancer therapy, antitubulin drugs remain the backbone of numerous oncological protocols and their efficacy has been demonstrated in a wide variety of adult and pediatric cancers.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a376e4099587cd0d5b66fcded2830aac
https://pubmed.ncbi.nlm.nih.gov/36370553

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Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists?

Autor: Ubaldina Galli, Silvio Aprile, Beatrice Purghè, Gian Cesare Tron, Giorgio Grosa

Publikováno v: Chemical Research in Toxicology. 33:955-966

Despite the isolation of hundreds of bioactive isocyanides from terrestrial fungi and bacteria as well as marine organisms, the isocyanide functionality has so far received little attention from a medicinal chemistry standpoint. The widespread tenet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ee7e1caad4eea20fc0af0408efc4bd
https://doi.org/10.1021/acs.chemrestox.9b00504

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A nicotinamide phosphoribosyltransferase–GAPDH interaction sustains the stress-induced NMN/NAD+ salvage pathway in the nucleus

Publikováno v: 'Journal of Biological Chemistry ', vol: 295, pages: 3635-3651 (2020)
J Biol Chem
Journal of biological chemistry (Online) 295 (2020): 3635–3651. doi:10.1074/jbc.RA119.010571
info:cnr-pdr/source/autori:Grolla A.A.; Miggiano R.; Marino D.D.; Bianchi M.; Gori A.; Orsomando G.; Gaudino F.; Galli U.; Grosso E.D.; Mazzola F.; Angeletti C.; Guarneri M.; Torretta S.; Calabro M.; Boumya S.; Fan X.; Colombo G.; Travelli C.; Rocchio F.; Aronica E.; Wohlschlegel J.A.; Deaglio S.; Rizzi M.; Genazzani A.A.; Garavaglia S./titolo:A nicotinamide phosphoribosyltransferase-GAPDH interaction sustains the stress-induced NMN%2FNAD+ salvage pathway in the nucleus/doi:10.1074%2Fjbc.RA119.010571/rivista:Journal of biological chemistry (Online)/anno:2020/pagina_da:3635/pagina_a:3651/intervallo_pagine:3635–3651/volume:295
Journal of biological chemistry, 295(11), 3635-3651. American Society for Biochemistry and Molecular Biology Inc.

All cells require sustained intracellular energy flux, which is driven by redox chemistry at the subcellular level. NAD(+), its phosphorylated variant NAD(P)(+), and its reduced forms NAD(P)/NAD(P)H are all redox cofactors with key roles in energy me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28890c3e59b9c06bd51eee7db1ddd05
http://www.scopus.com/inward/record.url?scp=85081966881&partnerID=8YFLogxK

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