Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography.

Autor: Ubah OC; Elasmogen Ltd, Liberty Building Foresterhill Road, Aberdeen, AB25 2ZP, UK., Lake EW; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA., Gunaratne GS; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Gallant JP; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.; Molecular and Cellular Pharmacology Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA., Fernie M; Elasmogen Ltd, Liberty Building Foresterhill Road, Aberdeen, AB25 2ZP, UK., Robertson AJ; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.; Molecular and Cellular Pharmacology Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA., Marchant JS; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Bold TD; Division of Infectious Diseases and International Medicine, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.; Center for Immunology, University of Minnesota, Minneapolis, MN, 55455, USA., Langlois RA; Center for Immunology, University of Minnesota, Minneapolis, MN, 55455, USA.; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, 55455, USA., Matchett WE; Center for Immunology, University of Minnesota, Minneapolis, MN, 55455, USA.; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, 55455, USA., Thiede JM; Division of Infectious Diseases and International Medicine, University of Minnesota Medical School, Minneapolis, MN, 55455, USA., Shi K; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Yin L; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Moeller NH; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Banerjee S; Northeastern Collaborative Access Team, Cornell University, Advanced Photon Source, Lemont, IL, 60439, USA., Ferguson L; Elasmogen Ltd, Liberty Building Foresterhill Road, Aberdeen, AB25 2ZP, UK., Kovaleva M; Elasmogen Ltd, Liberty Building Foresterhill Road, Aberdeen, AB25 2ZP, UK., Porter AJ; Elasmogen Ltd, Liberty Building Foresterhill Road, Aberdeen, AB25 2ZP, UK.; School of Medical Sciences, Scottish Biologics Facility, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZP, UK., Aihara H; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA. aihar001@umn.edu., LeBeau AM; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA. aaron.lebeau@wisc.edu.; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA. aaron.lebeau@wisc.edu.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, 53705, USA. aaron.lebeau@wisc.edu., Barelle CJ; Elasmogen Ltd, Liberty Building Foresterhill Road, Aberdeen, AB25 2ZP, UK. caroline.barelle@elasmogen.com.

Publikováno v: Nature communications [Nat Commun] 2021 Dec 16; Vol. 12 (1), pp. 7325. Date of Electronic Publication: 2021 Dec 16.

In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties.

Autor: Steven J; Elasmogen Ltd., Aberdeen, UK., Ubah OC; Elasmogen Ltd., Aberdeen, UK. obinna.ubah@elasmogen.com., Buschhaus M; Elasmogen Ltd., Aberdeen, UK., Kovaleva M; Elasmogen Ltd., Aberdeen, UK., Ferguson L; Elasmogen Ltd., Aberdeen, UK., Porter AJ; Elasmogen Ltd., Aberdeen, UK.; Scottish Biologics Facility, School of Medical Sciences, University of Aberdeen, Aberdeen, UK., Barelle CJ; Elasmogen Ltd., Aberdeen, UK.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2020; Vol. 2070, pp. 115-142.

An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model.

Autor: Ubah OC; Elasmogen Ltd, Aberdeen, United Kingdom., Steven J; Elasmogen Ltd, Aberdeen, United Kingdom., Porter AJ; Elasmogen Ltd, Aberdeen, United Kingdom.; Scottish Biologics Facility, School of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom., Barelle CJ; Elasmogen Ltd, Aberdeen, United Kingdom.

Publikováno v: Frontiers in immunology [Front Immunol] 2019 Mar 22; Vol. 10, pp. 526. Date of Electronic Publication: 2019 Mar 22 (Print Publication: 2019).

Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development.

Autor: Ubah OC; Elasmogen Ltd., Aberdeen, Scotland., Steven J; Elasmogen Ltd., Aberdeen, Scotland., Kovaleva M; Elasmogen Ltd., Aberdeen, Scotland., Ferguson L; Elasmogen Ltd., Aberdeen, Scotland., Barelle C; Elasmogen Ltd., Aberdeen, Scotland., Porter AJR; Elasmogen Ltd., Aberdeen, Scotland.; Scottish Biologics Facility, Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland., Barelle CJ; Elasmogen Ltd., Aberdeen, Scotland.

Publikováno v: Frontiers in immunology [Front Immunol] 2017 Dec 22; Vol. 8, pp. 1780. Date of Electronic Publication: 2017 Dec 22 (Print Publication: 2017).

Phage Display Derived IgNAR V Region Binding Domains for Therapeutic Development.

Autor: Ubah OC, Barelle CJ; Elasmogen Limited, Liberty Building, Foresterhill Road, Aberdeen, AB25 2ZP, United Kingdom., Buschhaus MJ, Porter AJ

Publikováno v: Current pharmaceutical design [Curr Pharm Des] 2016; Vol. 22 (43), pp. 6519-6526.