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P32 Jak inhibitors Tofacitinib and Ruxolitinib do not improve functional deficits in dystrophin-deficient mdx mice

Autor: Bosco, C., Uaesoontrachoon, K., Srinivassane, S., Rowsell, J., Elustondo, P., Mackinnon, A., Nagaraju, K., Peterson, J.

Publikováno v: In Neuromuscular Disorders October 2023 33 Supplement 1:S105-S105

Comparison of the efficacy of second and third generation lentiviral vector transduced CAR CD19 T cells for use in the treatment of acute lymphoblastic leukemia both in vitro and in vivo models.

Autor: Sawaisorn P; Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Atjanasuppat K; Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Uaesoontrachoon K; Genepeutic Bio, Co. Ltd., Bangkok, Thailand., Rattananon P; Genepeutic Bio, Co. Ltd., Bangkok, Thailand., Treesuppharat W; Thammasat University Research Unit in Mechanisms of Drug Action and Molecular Imaging, Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathum Thani, Thailand., Hongeng S; Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Anurathapan U; Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Publikováno v: PloS one [PLoS One] 2023 Feb 13; Vol. 18 (2), pp. e0281735. Date of Electronic Publication: 2023 Feb 13 (Print Publication: 2023).

Mechanism of action and therapeutic route for a muscular dystrophy caused by a genetic defect in lipid metabolism.

Autor: Tavasoli M; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada., Lahire S; University of Reims Champagne-Ardenne, Reims, France., Sokolenko S; Department of Process Engineering & Applied Science, Dalhousie University, Halifax, NS, Canada., Novorolsky R; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada., Reid SA; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada., Lefsay A; Mass Spectrometry Core Facility, Dalhousie University, Halifax, NS, Canada., Otley MOC; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada., Uaesoontrachoon K; Agada Biosciences Inc., Halifax, NS, Canada., Rowsell J; Agada Biosciences Inc., Halifax, NS, Canada., Srinivassane S; Agada Biosciences Inc., Halifax, NS, Canada., Praest M; Agada Biosciences Inc., Halifax, NS, Canada., MacKinnon A; Agada Biosciences Inc., Halifax, NS, Canada., Mammoliti MS; Agada Biosciences Inc., Halifax, NS, Canada., Maloney AA; Agada Biosciences Inc., Halifax, NS, Canada., Moraca M; Agada Biosciences Inc., Halifax, NS, Canada., Pedro Fernandez-Murray J; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada., McKenna M; Agada Biosciences Inc., Halifax, NS, Canada., Sinal CJ; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada., Nagaraju K; Agada Biosciences Inc., Halifax, NS, Canada.; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, State University of New York (SUNY), Binghamton, NY, USA., Robertson GS; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada., Hoffman EP; Agada Biosciences Inc., Halifax, NS, Canada.; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, State University of New York (SUNY), Binghamton, NY, USA., McMaster CR; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada. christopher.mcmaster@dal.ca.

Publikováno v: Nature communications [Nat Commun] 2022 Mar 23; Vol. 13 (1), pp. 1559. Date of Electronic Publication: 2022 Mar 23.

DMD – ANIMAL MODELS & PRECLINICAL TREATMENT: P.217 Enhancing the rigor and reproducibility of preclinical efficacy drug trials for DMD using reduced number of wild type and mdx control mice

Autor: Gordish-Dressman, H., Uaesoontrachoon, K., Mackinnon, A., Mullen, A., Hoffman, E., Nagaraju, K.

Publikováno v: In Neuromuscular Disorders October 2020 30 Supplement 1:S109-S109