Zobrazeno 1 - 10
of 1 196
pro vyhledávání: '"UTR, Untranslated regions"'
Whole genome analysis reveals the genomic complexity in metastatic cutaneous squamous cell carcinoma
Autor:
Amarinder Singh Thind, Bruce Ashford, Dario Strbenac, Jenny Mitchell, Jenny Lee, Simon A. Mueller, Elahe Minaei, Jay R. Perry, Sydney Ch’ng, N. Gopalakrishna Iyer, Jonathan R. Clark, Ruta Gupta, Marie Ranson
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Metastatic cutaneous squamous cell carcinoma (CSCC) is a highly morbid disease requiring radical surgery and adjuvant therapy, which is associated with a poor prognosis. Yet, compared to other advanced malignancies, relatively little is known of the
Externí odkaz:
https://doaj.org/article/1b54380ef9a04de4ae59a33d8f21f44b
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Pulmonary Arterial Hypertension (PAH) is a rare disease caused by the obliteration of the pulmonary arterioles, increasing pulmonary vascular resistance and eventually causing right heart failure. Endothelin-1 (EDN1) is a vasoconstrictor peptide whos
Externí odkaz:
https://doaj.org/article/0d4909038dc14a539676e321c75126e3
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 910-928 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 910-928 (2021)
Graphical abstract
Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA molecules derived from exonic or intronic sequences by precursor mRNA back-splicing. Unlike canonical linear RNAs, circRNAs form covalently
Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA molecules derived from exonic or intronic sequences by precursor mRNA back-splicing. Unlike canonical linear RNAs, circRNAs form covalently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d700dc693b3eae73dc74ae3cdbbdf6
http://europepmc.org/articles/PMC7851342
http://europepmc.org/articles/PMC7851342
Autor:
Ishtiaque Ahammad, Samia Sultana Lira
Publikováno v:
International Journal of Biological Macromolecules
SARS-CoV-2 is the deadly virus behind COVID-19, the disease that went on to ravage the world and caused the biggest pandemic 21st century has witnessed so far. On the face of ongoing death and destruction, the urgent need for the discovery of a vacci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352a07660711c1227db925386eb3a8b5
https://doi.org/10.1016/j.ijbiomac.2020.06.213
https://doi.org/10.1016/j.ijbiomac.2020.06.213
Autor:
Christine M. Akamine, Hana M. El Sahly
Publikováno v:
Translational Research
The mRNA therapeutics have been studied since the 1970s and the currently available mRNA vaccines against COVID-19 are the culmination of decades of scientific research. The mRNA vaccines BNT162b2 and mRNA-1273 have played a key role in our global re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fb17a5ba87457527cd1ba281170c15
https://pubmed.ncbi.nlm.nih.gov/34954088
https://pubmed.ncbi.nlm.nih.gov/34954088
Akademický článek
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Publikováno v:
Bioorganic Chemistry
Graphical abstract
SARS-CoV-2 is the pathogen that caused the global COVID-19 outbreak in 2020. Promising progress has been made in developing vaccines and antiviral drugs. Antivirals medicines are necessary complements of vaccines for post-infe
SARS-CoV-2 is the pathogen that caused the global COVID-19 outbreak in 2020. Promising progress has been made in developing vaccines and antiviral drugs. Antivirals medicines are necessary complements of vaccines for post-infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64603f79f7dca1b2529aabbb2a2d9f48
https://pubmed.ncbi.nlm.nih.gov/33667900
https://pubmed.ncbi.nlm.nih.gov/33667900
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Autor:
Mao Nakayama, Subhabrata Chakrabarti, Inderjeet Kaur, Margaret M DeAngelis, Taraprasad Das, Toru Noda, Megumi Yamamoto, Daisuke Iejima, Paul N. Baird, Akiko Suga, Robyn H. Guymer, Takeshi Iwata, Yang Pan
Publikováno v:
The Journal of Biological Chemistry
The disease-initiating molecular events for age-related macular degeneration (AMD), a multifactorial retinal disease affecting many millions of elderly individuals worldwide, are still unknown. Of the over 30 risk and protective loci so far associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47857712d23c3c53fbf629db43532576
https://doi.org/10.1016/j.jbc.2021.100456
https://doi.org/10.1016/j.jbc.2021.100456
Publikováno v:
Isakov, O, Wallis, D, Evans, D G & Ben-shachar, S 2018, ' Exhaustive non-synonymous variants functionality prediction enables high resolution characterization of the neurofibromin architecture ', EBioMedicine, vol. 36 . https://doi.org/10.1016/j.ebiom.2018.09.039
EBioMedicine
EBioMedicine
Background Neurofibromatosis type I (NF1) is caused by heterozygous loss-of-function variants in the NF1 gene encoding neurofibromin which serves as a tumor suppressor that inhibits RAS signaling and regulates cell proliferation and differentiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82854d153e0aebf0fdf4276732ba418c
https://doi.org/10.1016/j.ebiom.2018.09.039
https://doi.org/10.1016/j.ebiom.2018.09.039
