Zobrazeno 1 - 10
of 4 301
pro vyhledávání: '"UTR"'
Autor:
Aneela Mustafa, Maria Shabbir, Yasmin Badshah, Khushbukhat Khan, Fizzah Abid, Janeen H. Trembley, Tayyaba Afsar, Ali Almajwal, Suhail Razak
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Variations in untranslated regions (UTR) alter regulatory pathways impacting phenotype, disease onset, and course of disease. Protein kinase C Zeta (PRKCZ), a serine-threonine kinase, is implicated in cardiovascular, neurological
Externí odkaz:
https://doaj.org/article/26f43689afa74e5cbf7f1e4a28e45a0a
Autor:
Xiaoshan Tang, Miaozhe Huo, Yuting Chen, Hai Huang, Shugang Qin, Jiaqi Luo, Zeyi Qin, Xin Jiang, Yongmei Liu, Xing Duan, Ruohan Wang, Lingxi Chen, Hao Li, Na Fan, Zhongshan He, Xi He, Bairong Shen, Shuai Cheng Li, Xiangrong Song
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 4, Pp 1814-1826 (2024)
Efficient translation mediated by the 5′ untranslated region (5′ UTR) is essential for the robust efficacy of mRNA vaccines. However, the N1-methyl-pseudouridine (m1Ψ) modification of mRNA can impact the translation efficiency of the 5′ UTR. W
Externí odkaz:
https://doaj.org/article/86ce24bef18c4089ae453704e1c42e55
Autor:
Tianru Zhang, Changhao Li, Jiaying Zhu, Yanjun Li, Zhiye Wang, Chun-Yip Tong, Yu Xi, Yi Han, Hisashi Koiwa, Xu Peng, Xiuren Zhang
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-31 (2024)
Abstract Background RNA secondary structure (RSS) can influence the regulation of transcription, RNA processing, and protein synthesis, among other processes. 3′ untranslated regions (3′ UTRs) of mRNA also hold the key for many aspects of gene re
Externí odkaz:
https://doaj.org/article/cce8238e71cf407d8e1a085baa61602d
Autor:
Sara Esther Ramos-Lorente, Beatriz Berzal-Herranz, Cristina Romero-López, Alfredo Berzal-Herranz
Publikováno v:
Virus Research, Vol 343, Iss , Pp 199340- (2024)
Flaviviral RNA genomes are composed of discrete RNA structural units arranged in an ordered fashion and grouped into complex folded domains that regulate essential viral functions, e.g. replication and translation. This is achieved by adjusting the o
Externí odkaz:
https://doaj.org/article/4188eac997214cc1a558923c968b2f73
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-15 (2024)
Abstract Background The 5´ untranslated region (5´ UTR) plays a key role in regulating translation efficiency and mRNA stability, making it a favored target in genetic engineering and synthetic biology. A common feature found in the 5´ UTR is the
Externí odkaz:
https://doaj.org/article/a18506c7e8cf4b8d8d21ec074347e48a
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10135 (2024)
MicroRNAs (miRNAs) are molecules that influence messenger RNA (mRNA) expression levels by binding to the 3′ untranslated region (3′ UTR) of target genes. Host miRNAs can influence flavivirus replication, either by inducing changes in the host tra
Externí odkaz:
https://doaj.org/article/add882e2f3df437bb3035a35f151a8ba
Publikováno v:
Virus Research, Vol 341, Iss , Pp 199309- (2024)
Newcastle disease virus (NDV) is an avian virus and a promising vector for the development of vaccines for veterinary and human use. The optimal vaccine vector performance requires a stable high-level expression of a transgene. The foreign genes are
Externí odkaz:
https://doaj.org/article/20c42b5747184ad5897f8619b6577a7b
Autor:
Christopher C. T. Sng, Ashwin Adrian Kallor, Benjamin S. Simpson, Georges Bedran, Javier Alfaro, Kevin Litchfield
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundNeoantigens, mutated tumour-specific antigens, are key targets of anti-tumour immunity during checkpoint inhibitor (CPI) treatment. Their identification is fundamental to designing neoantigen-directed therapy. Non-canonical neoantigens aris
Externí odkaz:
https://doaj.org/article/629de0b0a96c4d8886c40bcceb5bfaa1
Autor:
Muhammad Safdar, PhD, Mehmet Ozaslan, PhD, Rebaz M. Mustafa, MSC, Shukur W. Smail, MSC, Samiha S. Khan, MBBS, Muhammad Sajjad Khan, PhD, Muhammad Asad Akhtar, MSC, Hafiz Khawar Ali, MSC, Umair Younas, PhD, Muhammad Saeed, PhD, Faisal Siddique, PhD, Muhammad Naveed, PhD, SaifUr Rehman, PhD
Publikováno v:
Journal of Taibah University Medical Sciences, Vol 18, Iss 5, Pp 1030-1047 (2023)
الملخص: أهداف البحث: يستهدف فيروس كورونا سارس-2 مستقبل الإنزيم المحول للمستضد 2، مما يؤدي إلى ارتفاع معدلات الإصابة بالأمراض وزيادة خطر ال
Externí odkaz:
https://doaj.org/article/e297b5eedae6410aa03a94bac0563d1e
Autor:
Shahab Mamaghani, Rocco Roberto Penna, Julia Frei, Conrad Wyss, Mark Mellett, Thomas Look, Tobias Weiss, Emmanuella Guenova, Thomas M. Kündig, Severin Lauchli, Steve Pascolo
Publikováno v:
Cells, Vol 13, Iss 15, p 1242 (2024)
Synthetic mRNA produced by in vitro transcription (ivt mRNA) is the active pharmaceutical ingredient of approved anti-COVID-19 vaccines and of many drugs under development. Such synthetic mRNA typically contains several hundred bases of non-coding
Externí odkaz:
https://doaj.org/article/5431fc445dd74b9097329e29d690d397