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Studies on the Conversion of Haloperidol and Its Tetrahydropyridine Dehydration Product to Potentially Neurotoxic Pyridinium Metabolites by Human Liver Microsomes

Autor: Andrew Parkinson, Castagnol N, Usuki E, Pearce R

Publikováno v: Chemical Research in Toxicology. 9:800-806

The neuroleptic agent haloperidol (HP) and its tetrahydropyridine dehydration product HPTP are biotransformed to the potentially neurotoxic HP pyridinium species HPP+ and the reduced HP pyridinium species RHPP+ in humans and rodents. The studies repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b42756cf1078b50290cf6c1dbe363e
https://doi.org/10.1021/tx960001y

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CYP4F Enzymes Are the Major Enzymes in Human Liver Microsomes That Catalyze the O-Demethylation of the Antiparasitic Prodrug DB289 [2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime]

Autor: Saulter, J. Y., Bridges, A. S., Parkinson, O. T., Zeldin, D. C., Hall, J. E., Hall, M., Paine, M. F., Wang, M. Z., Cheung, Y.-L., Boykin, D. W., Tidwell, R. R., Usuki, E., Allen, J. L., Parkinson, A., Loewen, G., Stephens, C. E.

DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime] is biotransformed to the potent antiparasitic diamidine DB75 [2,5-bis(4-amidinophenyl) furan] by sequential oxidative O-demethylation and reductive N-dehydroxylation reactions. Previous work

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d90a502e72a263b1a91230c0c902381d

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Metabolic studies on haloperidol and its tetrahydropyridine analog in C57BL/6 mice

Autor: Van der Schyf Cj, Neal Castagnoli, Usuki E, Fouda Hg, John M. Rimoldi, Kay Castagnoli

Publikováno v: Chemical research in toxicology. 7(3)

The neuroleptic agent haloperidol (HP) is biotransformed in humans to a pyridinium metabolite, HPP+, that displays neurotoxic properties resembling those of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-derived neurotoxic pyridinium metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63dfb0322ebd92cc511ff3b616b8c68
https://pubmed.ncbi.nlm.nih.gov/8075357

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MPP(+)-LIKE NEUROTOXICITY OF A PYRIDINIUM METABOLITE DERIVED FROM HALOPERIDOL - IN-VIVO MICRODIALYSIS AND IN-VITRO MITOCHONDRIAL STUDIES

Autor: ROLLEMA, H, SKOLNIK, M, DENGELBRONNER, J, IGARASHI, K, USUKI, E, CASTAGNOLI, N

Publikováno v: Journal of Pharmacology and Experimental Therapeutics, 268(1), 380-387. WILLIAMS & WILKINS

Intracerebral (intrastriatal, intranigral and intracortical) microdialysis studies were conducted in conscious rats to investigate the comparative dopaminergic and serotonergic neurotoxic potential of the pyridinium metabolite 4-(4-chlorophenyl)-1-[4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::a34d6740da1acc40955c500c9bd025f7
https://research.rug.nl/en/publications/c85942ed-20be-4ba1-a7c6-bb0784fe40a4

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MPP(+)-like neurotoxicity of a pyridinium metabolite derived from haloperidol: In vivo microdialysis and in vitro mitochondrial studies

Autor: Rollema, H, Skolnik, M, D'Engelbronner, J, Castagnoli Jr, N, Igarashi, K, Usuki, E, ROLLEMA, H, WESTERINK, BHC, DRIJFHOUT, WJ

Publikováno v: MONITORING MOLECULES IN NEUROSCIENCE, 367-369
STARTPAGE=367;ENDPAGE=369;TITLE=MONITORING MOLECULES IN NEUROSCIENCE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::458699d743642200130ae072eda08af3
https://research.rug.nl/en/publications/77745c2f-0933-4d07-9a40-1332af0974a4

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