Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors.

Autor: Bazua-Valenti S; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México., Brown MR; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA., Zavras J; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA., Riedl Khursigara M; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA., Grinkevich E; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA., Sidhom EH; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Keller KH; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Racette M; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA., Dvela-Levitt M; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel., Quintanova C; Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany., Demirci H; Institute of Translational Physiology and.; Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany., Sewerin S; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA., Goss AC; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Lin J; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA., Yoo H; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA., Vaca Jacome AS; Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Papanastasiou M; Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Udeshi N; Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Carr SA; Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Himmerkus N; Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany., Bleich M; Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany., Mutig K; Institute of Translational Physiology and.; Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany., Bachmann S; Institute of Translational Physiology and.; Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany., Halbritter J; Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Kmoch S; Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic., Živná M; Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic., Kidd K; Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA., Bleyer AJ; Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA., Weins A; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Alper SL; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.; Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Shaw JL; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA., Kost-Alimova M; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA., Pablo JLB; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA., Greka A; The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Dec 16; Vol. 134 (24). Date of Electronic Publication: 2024 Dec 16.

Advances in uromodulin biology and potential clinical applications.

Autor: Nanamatsu A; Department of Medicine, Division of Nephrology and Hypertension, Indiana University School of Medicine, Indianapolis, IN, USA., de Araújo L; Department of Medicine, Division of Nephrology and Hypertension, Indiana University School of Medicine, Indianapolis, IN, USA., LaFavers KA; Department of Medicine, Division of Nephrology and Hypertension, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA., El-Achkar TM; Department of Medicine, Division of Nephrology and Hypertension, Indiana University School of Medicine, Indianapolis, IN, USA. telachka@iu.edu.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA. telachka@iu.edu.; Roudebush VA Medical Center, Indianapolis, IN, USA. telachka@iu.edu.

Publikováno v: Nature reviews. Nephrology [Nat Rev Nephrol] 2024 Dec; Vol. 20 (12), pp. 806-821. Date of Electronic Publication: 2024 Aug 19.

Diagnosing Polyomavirus Nephropathy Without a Biopsy: Validation of the Urinary Polyomavirus-Haufen Test in a Proof-of-Concept Study Including Uromodulin Knockout Mice.

Autor: Nickeleit V; Department of Pathology and Laboratory Medicine, Division of Nephropathology, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, North Carolina, USA., Butcher D; Department of Pathology and Laboratory Medicine, Division of Nephropathology, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, North Carolina, USA., Thompson BD; Department of Pathology and Laboratory Medicine, Division of Nephropathology, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, North Carolina, USA., Rivier LH; Department of Pathology and Laboratory Medicine, Division of Nephropathology, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, North Carolina, USA., Singh HK; Department of Pathology and Laboratory Medicine, Division of Nephropathology, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, North Carolina, USA.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2024 Nov 15; Vol. 230 (5), pp. 1120-1129.

Relationship Between Serum Uromodulin as a Marker of Kidney Damage and Metabolic Status in Patients with Chronic Kidney Disease of Non-Diabetic Etiology.

Autor: Žeravica R; Department of Pathophysiology and Laboratory Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.; Center of Laboratory Diagnostic, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia., Ilinčić B; Department of Pathophysiology and Laboratory Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.; Center of Laboratory Diagnostic, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia., Burić D; Department of Pathophysiology and Laboratory Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.; Center of Laboratory Diagnostic, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia., Jakovljević A; Department of Pathophysiology and Laboratory Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.; Center of Laboratory Diagnostic, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia., Crnobrnja V; Department of Pathophysiology and Laboratory Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.; Center of Laboratory Diagnostic, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia., Ilić D; Center for Radiology, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia., Papuga MV; Center of Laboratory Diagnostic, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia.; Department of Nuclear Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Oct 17; Vol. 25 (20). Date of Electronic Publication: 2024 Oct 17.

Urinary Tamm-Horsfall protein excretion is a potential early biomarker of renal distal tubular damage in canine leishmaniosis.

Autor: Daza MA; Small Animal Emergency and ICU Service, Veterinary Teaching Hospital, Complutense University, Avda Puerta Hierro sn., Madrid 28040, Spain. Electronic address: madazago@ucm.es., Miró G; Dept. of Animal Health, Faculty of Veterinary Medicine, Complutense University, Avda Puerta hierro sn., Madrid 28040, Spain., Fragío C; Small Animal Emergency and ICU Service, Veterinary Teaching Hospital, Complutense University, Avda Puerta Hierro sn., Madrid 28040, Spain; Dept. of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Complutense University, Avda Puerta hierro sn., Madrid 28040, Spain., Perez-Montero B; Clinical Pathology Service, Veterinary Teaching Hospital, Complutense University, Avda Puerta Hierro sn., Madrid 28040, Spain., Esteban SB; Small Animal Emergency and ICU Service, Veterinary Teaching Hospital, Complutense University, Avda Puerta Hierro sn., Madrid 28040, Spain., Fermín ML; Dept. of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Complutense University, Avda Puerta hierro sn., Madrid 28040, Spain.

Publikováno v: Veterinary parasitology [Vet Parasitol] 2024 Oct; Vol. 331, pp. 110265. Date of Electronic Publication: 2024 Jul 17.