Zobrazeno 1 - 10
of 64
pro vyhledávání: '"URB602"'
Autor:
Francisco Javier Pavón, Antonia Serrano, Rémi Martin-Fardon, Loren H. Parsons, Fernando Rodríguez de Fonseca, David G. Stouffer, Ilham Polis, Marisa Roberto
Publikováno v:
Alcohol Clin Exp Res
BACKGROUND: Ethanol (EtOH) self-administration is particularly sensitive to the modulation of CB(1) signaling in the nucleus accumbens (NAc) shell, and EtOH consumption increases extracellular levels of the endogenous cannabinoid CB(1) receptor agoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af9160641c0457032864402df664441
https://doi.org/10.1111/acer.14456
https://doi.org/10.1111/acer.14456
Autor:
Fabrício A. Moreira, Juliana R Bastos, Rayssa B. Costa, Leonardo B.M. Resstel, Thércia G. Viana, Sara C. Hott, Cândido C. Coimbra, Frederico S. Mansur, Daniele C. Aguiar
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Recurrent panic attacks, comprising emotional and cardiovascular aversive responses, are common features in panic disorder, a subtype of anxiety disorder. The underlying brain circuitry includes nuclei of the hypothalamus, such as the dorsomedial hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e0831d6eca2815062560c8465863fe
https://doi.org/10.1016/j.neuropharm.2019.01.022
https://doi.org/10.1016/j.neuropharm.2019.01.022
Autor:
Jin Liu, Guo Chen, Cansheng Gong, Huan Li, Yan Cheng, Haixia Jiang, Yu-Qi Liu, Gang Zhang, Bowen Ke, Kerong Hai, Deying Gong, Xueyan Gou, Xing-Huan Li, Linghui Yang
Publikováno v:
Critical Care Medicine. 47:e144-e151
Objectives Monoacylglycerol lipase participates in organ protection by regulating the hydrolysis of the endocannabinoid 2-arachidonoylglycerol. This study investigated whether blocking monoacylglycerol lipase protects against postresuscitation myocar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a8d4721feeded556f72928efc70678
https://doi.org/10.1097/ccm.0000000000003552
https://doi.org/10.1097/ccm.0000000000003552
Autor:
Evan N. Graf, Elizabeth M. Doncheck, David A. Baker, Benjamin F. Cravatt, Cecilia J. Hillard, John R. Mantsch, Daisuke Ogasawara, Yan Li, Jayme R. McReynolds, Qing-song Liu, Oliver Vranjkovic
Publikováno v:
Biological Psychiatry. 84:85-94
Background Clinical reports suggest that rather than directly driving cocaine use, stress may create a biological context within which other triggers for drug use become more potent. We hypothesize that stress-induced increases in corticosterone “s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979b06c494780a64ad842a9cd98c3909
https://doi.org/10.1016/j.biopsych.2017.09.024
https://doi.org/10.1016/j.biopsych.2017.09.024
Autor:
Hideru Obinata, Chizu Aso, Akimitsu Konishi, Noriyasu Ohshima, Kazuaki Tatei, Takashi Izumi, Mari Araki
Publikováno v:
Journal of Biochemistry. 160:269-279
DDHD2 has been reported to exhibit phospholipase A1, triacylglycerol (TG) lipase and diacylglycerol (DG) lipase activities. However, the detailed enzymatic properties of DDHD2 have not yet been elucidated. In the current study, the substrate specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8264f8d39c26bc3402e7233c382c70a
https://doi.org/10.1093/jb/mvw034
https://doi.org/10.1093/jb/mvw034
Publikováno v:
Biochemical and biophysical research communications. 506(3)
Lung ischemia-reperfusion injury (LIRI) is a common and severe postoperative pathologic complication that often occurs when the oxygen supply disrupted to the lung tissue fallowed by reperfusion period, in most cases after lung transplantation and ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca4a63e39c28ff0973a1935640caf07
https://pubmed.ncbi.nlm.nih.gov/30366666
https://pubmed.ncbi.nlm.nih.gov/30366666
Autor:
Anke Witting, Johannes Hanselmann, Patrick Weydt, Boris Ferger, Christoph Porazik, Noemi Pasquarelli
Publikováno v:
Neuropharmacology. 91:148-156
Monoacylglycerol lipase (MAGL) is part of the endocannabinoid and the prostaglandin signaling system. MAGL degrades the endocannabinoid 2-arachidonoylglycerol (2-AG) into glycerol and arachidonic acid. MAGL-induced arachidonic acid is the primary sou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65663c7890c20a698b4a0866ea5e99ef
https://doi.org/10.1016/j.neuropharm.2014.12.001
https://doi.org/10.1016/j.neuropharm.2014.12.001
Autor:
Roberta Ottria, Cristiana Perrotta, Silvana Casati, Pierangela Ciuffreda, Ivano Eberini, Chiara Parravicini, Simone Lauria, Luca Palazzolo, Ilaria Di Renzo
Publikováno v:
Bioorganicmedicinal chemistry. 26(9)
Monoacylglycerol lipase (MAGL) has an essential role in the catabolic pathway of the endocannabinoid 2-arachidonoylglycerol, which makes it a potential target for highly specific inhibitors for the treatment of a number of diseases. We designed and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb33d7345533135ed2f302132ab39319
https://pubmed.ncbi.nlm.nih.gov/29678535
https://pubmed.ncbi.nlm.nih.gov/29678535
Autor:
Laura Berliocchi, Rosaria Greco, Cristina Tassorelli, Chiara Demartini, Daniele Piomelli, Anna Maria Zanaboni
Publikováno v:
Cephalalgia : an international journal of headache. 38(6)
Background Drugs that modulate endocannabinoid signalling are effective in reducing nociception in animal models of pain and may be of value in the treatment of migraine. Methods We investigated the anti-nociceptive effects of inhibition of monoacylg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56377025d228f31fe30e9754c673205f
https://pubmed.ncbi.nlm.nih.gov/28816506
https://pubmed.ncbi.nlm.nih.gov/28816506
Autor:
Ana F. Almeida-Santos, L.C. Rosa, Pedro H. Gobira, Daniele C. Aguiar, Fabrício A. Moreira, Francisco Silveira Guimarães
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Anandamide and 2-arachidonoylglycerol (2-AG) are the two main endocannabinoids, exerting their effects by activating type 1 (CB1r) and type 2 (CB2r) cannabinoid receptors. Anandamide inhibits anxiety-like responses through the activation of CB1r in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b79326ee70321c96c2d639b3a6529f9
https://doi.org/10.1016/j.bbr.2013.05.027
https://doi.org/10.1016/j.bbr.2013.05.027