Zobrazeno 1 - 10
of 234
pro vyhledávání: '"UPR – unfolded protein response"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Neuronal loss is one of the striking causes of various central nervous system (CNS) disorders, including major neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and Amyotrophic la
Externí odkaz:
https://doaj.org/article/5a8fb61d7e364d43b789a4c9e9800467
Autor:
Antoine Domenger, Daniela Ricci, Véronique Mayau, Laleh Majlessi, Christophe Marcireau, Gilles Dadaglio, Caroline Demangel
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Multiple Myeloma (MM) is an incurable neoplasm of mature B cells and the second most prevalent hematological malignancy worldwide. While combinations of proteasome inhibitors like bortezomib (Bz) and immunomodulators (IMiDs) like lenalinomide (Len) a
Externí odkaz:
https://doaj.org/article/4bf93cccf969455d81bfe0750633a531
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
The ER (endoplasmic reticulum) is the largest membrane-bound multifunctional organelle in eukaryotic cells, serving particularly important in protein synthesis, modification, folding and transport. UPR (unfolded protein response) is one of the system
Externí odkaz:
https://doaj.org/article/870ff56364c24445ae1ebd9adf1911c4
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
SOD1 mutations account for ∼20% of familial amyotrophic lateral sclerosis (ALS) cases in which the hallmark pathological feature is insoluble SOD1 aggregates within motor neurons. Here, we investigated the degradation and synthesis of mutant SOD1 t
Externí odkaz:
https://doaj.org/article/cb509023f6e049ed9739bbae0164f696
Autor:
Andrés Gámez-García, Idoia Bolinaga-Ayala, Guillermo Yoldi, Sergio Espinosa-Gil, Nora Diéguez-Martínez, Elisabet Megías-Roda, Pau Muñoz-Guardiola, Jose M. Lizcano
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Autophagy is a highly conserved intracellular process that preserves cellular homeostasis by mediating the lysosomal degradation of virtually any component of the cytoplasm. Autophagy is a key instrument of cellular response to several stresses, incl
Externí odkaz:
https://doaj.org/article/b087629e9a314cc7945f694a47bb7246
Autor:
Namita Chatterjee, Eugenia Fraile-Bethencourt, Adrian Baris, Cristina Espinosa-Diez, Sudarshan Anand
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Defects in stress responses are important contributors in many chronic conditions including cancer, cardiovascular disease, diabetes, and obesity-driven pathologies like non-alcoholic steatohepatitis (NASH). Specifically, endoplasmic reticulum (ER) s
Externí odkaz:
https://doaj.org/article/6160a66d8851434fa7e9206a22d6ebbb
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Glioblastoma (GBM) is the most common primary brain tumor, carrying a very poor prognosis, with median overall survival at about 12 to 15 months despite surgical resection, chemotherapy with temozolomide (TMZ), and radiation therapy. GBM recurs in th
Externí odkaz:
https://doaj.org/article/7d14a9f214384681b54a778cf4f88157
Autor:
Hamid el Azzouzi, Andreia P. Vilaça, Dries A. M. Feyen, Willemijn M. Gommans, Roel A. de Weger, Pieter A. F. Doevendans, Joost P. G. Sluijter
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Background: Adenosine deaminase acting on RNA 1 (ADAR1) is a double-stranded RNA-editing enzyme that is involved in several functions including the deamination of adenosine to inosine, RNA interference (RNAi) mechanisms and microRNA (miRNA) processin
Externí odkaz:
https://doaj.org/article/66d621fa95dc42239d8bdc45ae357a35
Autor:
Ji-Ae Choi, Chang-Hwa Song
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
The endoplasmic reticulum (ER) is the major organelle in the cell for protein folding and plays an important role in cellular functions. The unfolded protein response (UPR) is activated in response to misfolded or unfolded protein accumulation in the
Externí odkaz:
https://doaj.org/article/e482c4fed9444c00b020a9da000212fc
Autor:
Ester Zito, Ana Ferreiro
Publikováno v:
Cells, Vol 10, Iss 5, p 1116 (2021)
Selenoprotein N (SEPN1) is a type II glycoprotein of the endoplasmic reticulum (ER) that senses calcium levels to tune the activity of the sarcoplasmic reticulum calcium pump (SERCA pump) through a redox-mediated mechanism, modulating ER calcium home
Externí odkaz:
https://doaj.org/article/3220fb6433cb4d78bc03dd50074e0305