Zobrazeno 1 - 10
of 383
pro vyhledávání: '"UNC13D"'
Autor:
Van-Thanh Duong, Mihyang Ha, Jayoung Kim, Ji-Young Kim, Siyoung Park, Khatun Mst Reshma, Myoung-Eun Han, Dongjun Lee, Yun Hak Kim, Sae-Ock Oh
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Recycling of integrin via endosomal vesicles is critical for the migration of cancer cells, which leads to the metastasis of pancreatic cancer and devastating cancer-related death. So, new diagnostic and therapeutic molecules whic
Externí odkaz:
https://doaj.org/article/e9ced9b57e1a4614af71fced3770e5f6
Autor:
Yaning Ao, Yusheng Huang, Xiaobo Zhou, Jiawen Li, Qing Zhang, Sujun Wu, Ying Fu, Jinfeng Zhang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory disorder that occurs as a consequence of immune dysregulation. HLH can be primary (familial or non-familial) or secondary to infection, autoimmune disease or malignancy.
Externí odkaz:
https://doaj.org/article/06eba78fb3ee4d81a1e3a9905aaf9982
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
UNC13 family (also known as Munc13) proteins are evolutionarily conserved proteins involved in the rapid and regulated secretion of vesicles, including synaptic vesicles and cytotoxic granules. Fast and regulated secretion at the neuronal and immunol
Externí odkaz:
https://doaj.org/article/cc5da9dc5de64bcf92702c893e1eb816
Autor:
Liu Bingjie, Zhang Linlin, Ma Futian, Xuan Fan, Du Huan, Xiaoli Wu, Lixia Zhou, Wang Fuxu, Zhang Xuejun, Wang Ying
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectivesThis study aims to discuss the clinical manifestations and treatment of Familial hemophagocytic lymphohistiocytosis (FHL) caused by a mutation in the UNC13D gene.MethodsA 6-year-old female child presented with unexplained febricity, splenom
Externí odkaz:
https://doaj.org/article/4d3c620392604f40bccc116514eee400
Autor:
Chinmayee B. Nagaraj, Diana S. Brightman, Hannah Rea, Emily Wakefield, Nina V. G. Harkavy, Lisa Dyer, Wenying Zhang
Publikováno v:
BMC Pediatrics, Vol 24, Iss 1, Pp 1-5 (2024)
Abstract Background Familial hemophagocytic lymphohistiocytosis (FHL) is an immunological disorder characterized by overactivation of macrophages and T lymphocytes. This autosomal recessive condition has been characterized into multiple types dependi
Externí odkaz:
https://doaj.org/article/c97579fce5a342f29723d121ebc8a2e9
Autor:
Vanessa J. Dayton, Dang Hoang Thien, Phan Thi Xinh, Cade Arries, Nguyen Ngoc Sang, Ngo Ngoc Ngan Linh, Nguyen Phuong Lien, Phu Chi Dung
Publikováno v:
Diagnostic Pathology, Vol 18, Iss 1, Pp 1-8 (2023)
Abstract Background Using the World Health Organization Classification 5th edition (beta version online; WHO-HAEM5bv) in emerging economies is key to global healthcare equity. Although there may be ongoing updates, hesitancy in accepting and reportin
Externí odkaz:
https://doaj.org/article/37e51e69494546f4afb3b5495aa4dcd2
Akademický článek
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Autor:
Payman Sadeghi, Golnaz Ghazizadeh Esslami, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Reihaneh Mohsenipour
Publikováno v:
BMC Pediatrics, Vol 22, Iss 1, Pp 1-6 (2022)
Abstract Background Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease characterized by some clinical signs (e.g., non-remitting fever, hepatosplenomegaly) and laboratory findings (e.g., cytopenia, increased ferritin level, hypofi
Externí odkaz:
https://doaj.org/article/ee55f422fdc14bd685c425f2b55b26af
Autor:
Fa Jin, Chuanzhi Duan
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-12 (2022)
Abstract Background Moyamoya disease (MMD) is a rare chronic progressive cerebrovascular disease. Recent studies have shown that autoimmune inflammation may also be an important pathology in MMD but the molecular mechanisms of inflammation in this di
Externí odkaz:
https://doaj.org/article/cd9c9d11e77d4ff3932ebee66f9ec318
Akademický článek
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