Zobrazeno 1 - 10
of 2 541
pro vyhledávání: '"ULK1"'
Autor:
Chong-Shuang Pei, Xiao-Ou Hou, Zhen-Yuan Ma, Hai-Yue Tu, Hai-Chun Qian, Yang Li, Kai Li, Chun-Feng Liu, Liang Ouyang, Jun-Yi Liu, Li-Fang Hu
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Background Autophagy dysfunction in glial cells is implicated in the pathogenesis of Parkinson’s disease (PD). The previous study reported that α-synuclein (α-Syn) disrupted autophagy in cultured microglia. However, the mechanism of micr
Externí odkaz:
https://doaj.org/article/74f57b9ac38040c38a6442c98ac07c8f
Autor:
Zuxi Feng, Yanghuan Ou, Xueqiang Deng, Minghao Deng, Xiaohua Yan, Leifeng Chen, Fan Zhou, Liang Hao
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Background Deubiquitinating enzymes (DUBs) are pivotal in maintaining cell homeostasis by regulating substrate protein ubiquitination in both healthy and cancer cells. Ubiquitin-specific protease 10 (USP10) belongs to the DUB family. In this
Externí odkaz:
https://doaj.org/article/a271d14a4a3747e086100fa1ec8bb918
Autor:
Huang Tingjuan, Zhang Chunhong, Ren Junjie, Shuai Qizhi, Li Xiaonan, Li Xuewei, Xie Jun, Xu Jun
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 1509-1520 (2024)
The activation of hepatic stellate cells (HSCs) is central to the occurrence and development of liver fibrosis. Our previous studies showed that autophagy promotes HSC activation and ultimately accelerates liver fibrosis. Unc-51-like autophagy activa
Externí odkaz:
https://doaj.org/article/037471f553424b37a2fe709baae89523
Autor:
Wei Chen, Kai-Bin Yang, Yuan-Zhe Zhang, Zai-Shan Lin, Jin-Wei Chen, Si-Fan Qi, Chen-Fei Wu, Gong-Kan Feng, Da-Jun Yang, Ming Chen, Xiao-Feng Zhu, Xuan Li
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Background High expression of ubiquitin ligase MDM2 is a primary cause of p53 inactivation in many tumors, making it a promising therapeutic target. However, MDM2 inhibitors have failed in clinical trials due to p53-induced feedback that enh
Externí odkaz:
https://doaj.org/article/36aa2479810046219abd7234f4f5e8a9
Autor:
Liyuan Zhang, Dongli Liang, Kaijun Min, Jiaxin Liang, Yu Tian, Cheng Liu, Ting Rong Luo, Xiaoning Li
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Signal transducer and activator of transcription 1 (STAT1) plays a critical role in immune response, human STAT1 as a transcriptional suppressor of autophagy genes and autophagic activity. Classical swine fever virus (CSFV)-infected induce autophagy,
Externí odkaz:
https://doaj.org/article/b9e03d5d177c47cda4f219f120fde4aa
Publikováno v:
Cancer Reports, Vol 7, Iss 9, Pp n/a-n/a (2024)
ABSTRACT Background and Aims CircRNAs and autophagy are closely involved in the physiological and pathological processes of ovarian cancer; however, their exact mechanisms are still undetermined. This investigation aimed to elucidate the function and
Externí odkaz:
https://doaj.org/article/87029dfaf70c4ec5a7884879d327c686
Autor:
Haifeng Zhang, Gaoran Ge, Wei Zhang, Houyi Sun, Xiaolong Liang, Yu Xia, Jiacheng Du, Zerui Wu, Jiaxiang Bai, Huilin Yang, Xing Yang, Jun Zhou, Yaozeng Xu, Dechun Geng
Publikováno v:
Advanced Science, Vol 11, Iss 36, Pp n/a-n/a (2024)
Abstract The molecular mechanism underlying abnormal osteoclastogenesis triggering subchondral bone remodeling in osteoarthritis (OA) is still unclear. Here, single‐cell and bulk transcriptomics sequencing analyses are performed on GEO datasets to
Externí odkaz:
https://doaj.org/article/52ae74f826ad4f01936ae0a98cdeee8f
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117260- (2024)
The five-year survival rate for patients with hepatocellular carcinoma (HCC) is only 20 %, highlighting the urgent need to identify new therapeutic targets and develop potential therapeutic options to improve patient prognosis. One promising approach
Externí odkaz:
https://doaj.org/article/381554c557514d59a2f0fd0dfad5488a
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 789-804 (2024)
Acute lung injury (ALI) is a serious condition characterized by damage to the lungs. Recent research has revealed that activation of the NLRP3 inflammasome in alveolar macrophages, a type of immune cell in the lungs, plays a key role in the developme
Externí odkaz:
https://doaj.org/article/80cb9cd8d48d47a684846d94012535f5
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