Zobrazeno 1 - 10 of 31 120 pro vyhledávání: '"ULK1"'
1
Akademický článek
ULK1 在炎症性疾病中的研究进展.
Autor: 刘婉婷1 1219420640@qq.com, 徐畅1, 王重阳1, 宋艺兰1, 李莉1, 延光海1 ghyan@ybu.edu.cn
Publikováno v: Chinese Journal of Immunology. Jun2024, Vol. 40 Issue 6, p1302-1314. 6p.
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2
Akademický článek
α-Synuclein disrupts microglial autophagy through STAT1-dependent suppression of Ulk1 transcription.
Autor: Pei, Chong-Shuang1,2 (AUTHOR), Hou, Xiao-Ou1,2 (AUTHOR), Ma, Zhen-Yuan2 (AUTHOR), Tu, Hai-Yue2 (AUTHOR), Qian, Hai-Chun2 (AUTHOR), Li, Yang3 (AUTHOR), Li, Kai1 (AUTHOR), Liu, Chun-Feng1,2 (AUTHOR), Ouyang, Liang3 (AUTHOR) ouyangliang@scu.edu.cn, Liu, Jun-Yi4 (AUTHOR) jyliu911@suda.edu.cn, Hu, Li-Fang1,2,5 (AUTHOR) hulifang@suda.edu.cn
Publikováno v: Journal of Neuroinflammation. 10/26/2024, Vol. 21 Issue 1, p1-19. 19p.
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3
Akademický článek
PP2Ac Regulates Autophagy via Mediating mTORC1 and ULK1 During Osteoclastogenesis in the Subchondral Bone of Osteoarthritis.
Autor: Zhang, Haifeng1,2 (AUTHOR), Ge, Gaoran1 (AUTHOR), Zhang, Wei1 (AUTHOR), Sun, Houyi3 (AUTHOR), Liang, Xiaolong1 (AUTHOR), Xia, Yu1 (AUTHOR), Du, Jiacheng4 (AUTHOR), Wu, Zerui1,5 (AUTHOR), Bai, Jiaxiang1,6 (AUTHOR), Yang, Huilin1 (AUTHOR), Yang, Xing7 (AUTHOR) xingyangsz@njmu.edu.cn, Zhou, Jun1 (AUTHOR) zhoujun@suda.edu.cn, Xu, Yaozeng1 (AUTHOR) xuyaozeng@suda.edu.cn, Geng, Dechun1 (AUTHOR) szgengdc@suda.edu.cn
Publikováno v: Advanced Science. 9/25/2024, Vol. 11 Issue 36, p1-16. 16p.
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4
Akademický článek
Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.
Autor: Chen, Wei1,2,3,4 (AUTHOR), Yang, Kai-Bin1,2 (AUTHOR), Zhang, Yuan-Zhe1,2 (AUTHOR), Lin, Zai-Shan1,2 (AUTHOR), Chen, Jin-Wei2 (AUTHOR), Qi, Si-Fan2 (AUTHOR), Wu, Chen-Fei1,2,4 (AUTHOR), Feng, Gong-Kan2 (AUTHOR), Yang, Da-Jun2 (AUTHOR) yangdj@sysucc.org.cn, Chen, Ming1,2 (AUTHOR) chenm326@mail.sysu.edu.cn, Zhu, Xiao-Feng2 (AUTHOR) zhuxfeng@mail.sysu.edu.cn, Li, Xuan1,2 (AUTHOR) lixuan56@mail.sysu.edu.cn
Publikováno v: Journal of Experimental & Clinical Cancer Research (17569966). 8/31/2024, Vol. 43 Issue 1, p1-20. 20p.
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5
Akademický článek
α-Synuclein disrupts microglial autophagy through STAT1-dependent suppression of Ulk1 transcription
Autor: Chong-Shuang Pei, Xiao-Ou Hou, Zhen-Yuan Ma, Hai-Yue Tu, Hai-Chun Qian, Yang Li, Kai Li, Chun-Feng Liu, Liang Ouyang, Jun-Yi Liu, Li-Fang Hu
Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Background Autophagy dysfunction in glial cells is implicated in the pathogenesis of Parkinson’s disease (PD). The previous study reported that α-synuclein (α-Syn) disrupted autophagy in cultured microglia. However, the mechanism of micr
Externí odkaz: https://doaj.org/article/74f57b9ac38040c38a6442c98ac07c8f
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6
Akademický článek
MiR-139-5p 通过 ULK1 减弱细胞自噬而抑制 非小细胞肺癌.
Autor: 江泽勇1, 赵 健1, 吴文杰1, 陈国硕2 ccc1987@163.com
Publikováno v: Guangdong Medical Journal. Aug2024, Vol. 45 Issue 8, p959-969. 11p.
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7
Akademický článek
FTO-mediated m 6A demethylation of ULK1 mRNA promotes autophagy and activation of hepatic stellate cells in liver fibrosis
Autor: Huang Tingjuan, Zhang Chunhong, Ren Junjie, Shuai Qizhi, Li Xiaonan, Li Xuewei, Xie Jun, Xu Jun
Publikováno v: Acta Biochimica et Biophysica Sinica, Vol 56, Pp 1509-1520 (2024)
The activation of hepatic stellate cells (HSCs) is central to the occurrence and development of liver fibrosis. Our previous studies showed that autophagy promotes HSC activation and ultimately accelerates liver fibrosis. Unc-51-like autophagy activa
Externí odkaz: https://doaj.org/article/037471f553424b37a2fe709baae89523
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8
Akademický článek
Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling
Autor: Wei Chen, Kai-Bin Yang, Yuan-Zhe Zhang, Zai-Shan Lin, Jin-Wei Chen, Si-Fan Qi, Chen-Fei Wu, Gong-Kan Feng, Da-Jun Yang, Ming Chen, Xiao-Feng Zhu, Xuan Li
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Background High expression of ubiquitin ligase MDM2 is a primary cause of p53 inactivation in many tumors, making it a promising therapeutic target. However, MDM2 inhibitors have failed in clinical trials due to p53-induced feedback that enh
Externí odkaz: https://doaj.org/article/36aa2479810046219abd7234f4f5e8a9
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9
Akademický článek
Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression.
Autor: Yanagi, Tomoki1 (AUTHOR), Kikuchi, Hiroaki1,2 (AUTHOR), Susa, Koichiro1 (AUTHOR), Takahashi, Naohiro1 (AUTHOR), Bamba, Hiroki1 (AUTHOR), Suzuki, Takefumi1 (AUTHOR), Nakano, Yuta1 (AUTHOR), Fujiki, Tamami1 (AUTHOR), Mori, Yutaro1 (AUTHOR), Ando, Fumiaki1 (AUTHOR), Mandai, Shintaro1 (AUTHOR), Mori, Takayasu1 (AUTHOR), Takeuchi, Koh3 (AUTHOR), Honda, Shinya4 (AUTHOR), Torii, Satoru4 (AUTHOR), Shimizu, Shigeomi4 (AUTHOR), Rai, Tatemitsu1 (AUTHOR), Uchida, Shinichi1 (AUTHOR), Sohara, Eisei1 (AUTHOR) esohara.kid@tmd.ac.jp
Publikováno v: Genes to Cells. Jan2023, Vol. 28 Issue 1, p5-14. 10p.
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10
Akademický článek
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