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Akademický článek

Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls.

Autor: María Soler Artigas, Louise V Wain, Nick Shrine, Tricia M McKeever, UK BiLEVE, Ian Sayers, Ian P Hall, Martin D Tobin

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0170222 (2017)

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide; smoking is the main risk factor for COPD, but genetic factors are also relevant contributors. Genome-wide association studies (GWAS) of the lung function meas

Externí odkaz: https://doaj.org/article/69a81af909cb4e1fa0f023e890b9dfd7

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Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

Autor: Hobbs, BD, de Jong, K, Lamontagne, M, Bossé, Y, Shrine, N, Artigas, MS, Wain, LV, Hall, IP, Jackson, VE, Wyss, AB, London, SJ, North, KE, Franceschini, N, Strachan, DP, Beaty, TH, Hokanson, JE, Crapo, JD, Castaldi, PJ, Chase, RP, Bartz, TM, Heckbert, SR, Psaty, BM, Gharib, SA, Zanen, P, Lammers, JW, Oudkerk, M, Groen, HJ, Locantore, N, Tal-Singer, R, Rennard, SI, Vestbo, J, Timens, W, Paré, PD, Latourelle, JC, Dupuis, J, O'Connor, GT, Wilk, JB, Kim, WJ, Lee, MK, Oh, Y-M, Vonk, JM, de Koning, HJ, Leng, S, Belinsky, SA, Tesfaigzi, Y, Manichaikul, A, Wang, X-Q, Rich, SS, Barr, RG, Sparrow, D, Litonjua, AA, Bakke, P, Gulsvik, A, Lahousse, L, Brusselle, GG, Stricker, BH, Uitterlinden, AG, Ampleford, EJ, Bleecker, ER, Woodruff, PG, Meyers, DA, Qiao, D, Lomas, DA, Yim, J-J, Kim, DK, Hawrylkiewicz, I, Sliwinski, P, Hardin, M, Fingerlin, TE, Schwartz, DA, Postma, DS, MacNee, W, Tobin, MD, Silverman, EK, Boezen, HM, Cho, MH, COPDGene Investigators, ECLIPSE Investigators, LifeLines Investigators, SPIROMICS Research Group, International COPD Genetics Network Investigators, UK BiLEVE Investigators, International COPD Genetics Consortium

Publikováno v: Nature Genetics

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10(-6)) in 9,498 cases and 9,748 co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::834c3a21a0c01477de684e2e7b49ebc3
https://openaccess.sgul.ac.uk/id/eprint/108399/7/NG-LE43518R_main_paper.pdf

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Genome-wide association study of copy number variation with lung function identifies a novel signal of association near BANP for forced vital capacity

BACKGROUND: Genome-wide association studies of Single Nucleotide Polymorphisms (SNPs) have identified 55 SNPs associated with lung function. However, little is known about the effect of copy number variants (CNVs) on lung function, although CNVs repr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::01e28a3927075f07b2d241edd24f30da
https://openaccess.sgul.ac.uk/id/eprint/108238/1/art%3A10.1186%2Fs12863-016-0423-0.pdf

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Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls

Autor: Nick Shrine, UK BiLEVE, Ian P. Hall, Louise V. Wain, Ian Sayers, Martin D. Tobin, María Soler Artigas, Tricia M. McKeever

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0170222 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc1bb9beeb74f94ef7398cf851c9abf
https://pubmed.ncbi.nlm.nih.gov/28114305

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Genome-wide association study of copy number variation with lung function identifies a novel signal of association near BANP for forced vital capacity

Publikováno v: BMC Genetics
Shrine, N, Tobin, M D, Schurmann, C, Soler Artigas, M, Hui, J, Lehtimäki, T, Raitakari, O T, Pennell, C E, Ang, Q W, Strachan, D P, Homuth, G, Gläser, S, Felix, S B, Evans, D M, Henderson, J, Granell, R, Palmer, L J, Huffman, J, Hayward, C, Malarstig, A & Musk, B & James, A L & Wain, L V 2016, ' Genome-wide association study of copy number variation with lung function identifies a novel signal of association near BANP for forced vital capacity ', BMC Genetics, vol. 17, no. 1, pp. 116 . https://doi.org/10.1186/s12863-016-0423-0
Shrine, N R G, Tobin, M, Schurmann, C, Soler Artigas, M, Hui, J, Lehtimäki, T, Pennell, C E, Ang, Q W, Strachan, D P, Homuth, G, Gläser, S, Felix, S B, Evans, D, Henderson, A J W, Granell, R, Palmer, L J, Hayward, C, Malarstig, A, Musk, B, James, A L & Wain, L V 2016, ' Genome-wide association study of copy number variation with lung function identifies a novel signal of association near BANP for Forced Vital Capacity ', BMC Genetics, vol. 17, 116 . https://doi.org/10.1186/s12863-016-0423-0

Background Genome-wide association studies of Single Nucleotide Polymorphisms (SNPs) have identified 55 SNPs associated with lung function. However, little is known about the effect of copy number variants (CNVs) on lung function, although CNVs repre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe18a4992719169434c6d0b1a1dcb16
https://pubmed.ncbi.nlm.nih.gov/27514831

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