Zobrazeno 1 - 10
of 2 531
pro vyhledávání: '"UGT1A1"'
Autor:
Cassandra White, Hannah Wardill, Christine Paul, Timothy Price, Christos Karapetis, Mark Nalder, Matthew E. Burge, Ann Thomas, Chris Oldmeadow, Daniel Barker, Laura C. Edney, Janet Coller, Joanne Bowen, Cheri Ostroff, Bruce Cheek, Mel Carlson, Trumaine Rankmore, Adnan Nagrial, Stephen Clarke, Lorraine Chantrill, Stephen Ackland, Rodney J. Scott
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Fluoropyrimidine (FP) chemotherapies are commonly prescribed for upper and lower gastrointestinal, breast and head and neck malignancies. Over 16,000 people with cancer require FP chemotherapies per annum in Australia. Between 10
Externí odkaz:
https://doaj.org/article/4dd039073fb249cbbecad007e14e1be9
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract We explore the allele and genotype distribution of UGT1A1 and BLVRA variants in individuals affected by neonatal hyperbilirubinemia in southern China. Blood specimens were collected from 240 neonates: 126 cases of hyperbilirubinemia and 114
Externí odkaz:
https://doaj.org/article/e9f6fe8702fa49499df8e899573266d8
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 5977-5983 (2024)
Yang Gou,1,2 Ping Wang,1,2 Wucheng Yang,1,2 Yimei Feng,1,2 Xiangui Peng,1,2 Hong Liu,1,2 Shuiqing Liu,1,2 Xi Zhang1,2 1Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, People’s Republic of China; 2Chongq
Externí odkaz:
https://doaj.org/article/fe651e64de214f6ea4ac553a599ec7c1
Autor:
Belén García-Fariña, Lydia Rink, Virginia Santarini, Marco Westkemper, Christian Dohna-Schwake, Birte Möhlendick
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background and aimsA number of case reports have documented the occurrence of acute hepatic and renal toxicity during treatment with deferasirox (DFX). The precise mechanisms underlying these adverse events remain unclear, with the time to toxicity v
Externí odkaz:
https://doaj.org/article/abda4726993243e0b7907c7145ae5a24
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Among the congener of dioxin, 2,3,7,8-TCDD is the most toxic, having a serious long-term impact on the environment and human health. UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a crucial role in the detoxification and excretion of endogen
Externí odkaz:
https://doaj.org/article/c5dcce2fa39a4fc693a62926d72c84e1
Publikováno v:
Future Pharmacology, Vol 4, Iss 2, Pp 317-335 (2024)
Pregnancy is associated with various physiological changes that can significantly impact the disposition of drugs. To further the insight into how pregnancy affects the pharmacokinetics of drugs at different stages, clinical studies can be simulated
Externí odkaz:
https://doaj.org/article/d7a4b6a7da2d454dbdbed7512c37f606
Publikováno v:
Balkan Journal of Medical Genetics, Vol 26, Iss 2, Pp 51-58 (2024)
Polymorphisms of the uridine-diphospho-glucuronosyltransferase 1A1 (UGT1A1) gene, hepatic solute carrier organic anion transporter 1B1/B3 (SLCO1B1/3) gene, and glutathione S-transferase (GST) gene have been associated with significant hyperbilirubine
Externí odkaz:
https://doaj.org/article/f0a167a8bd11475581a4bd49a09a51d2
Autor:
Megan H. Wong, Veronica C. Jones, Wai Yu, Linda D. Bosserman, Sayeh M. Lavasani, Niki Patel, Mina S. Sedrak, Daphne B. Stewart, James R. Waisman, Yuan Yuan, Joanne E. Mortimer
Publikováno v:
Cancer Medicine, Vol 13, Iss 16, Pp n/a-n/a (2024)
Abstract Background Sacituzumab govitecan (sacituzumab) emerged as an important agent in metastatic and locally recurrent HER2‐negative breast cancer treatment. UGT1A1 polymorphisms have also been shown to predict sacituzumab toxicity. Methods In t
Externí odkaz:
https://doaj.org/article/0465163b93754afbb3f4e1d59911ae8a
Autor:
Ling Guo, Xuewei Zhang, Xinwei Li, Kai Wang, Yanhua Wang, Alimire Abulikemu, Xizi Su, Mushui Shu, Haibin Li, Shiwei Cui, Zhizhen Xu, Haoyuan Tian, Yong Niu, Huige Yuan, Zhizhou He, Xin Sun, Huawei Duan
Publikováno v:
Environment International, Vol 190, Iss , Pp 108922- (2024)
Background: Benzo(a)pyrene (B[a]P) is the most widely concerned polycyclic aromatic hydrocarbons (PAHs), which metabolizes benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) in vivo to produce carcinogenic effect on the body. Currently, there is limi
Externí odkaz:
https://doaj.org/article/5106da60d6f344bd998834f1b5a7ba4f
Autor:
Jakub Wawrzkowicz, Monika Korga, Paweł Pawlik, Przemysław Zaroda, Paweł Dąda, Patrycja Niewinna, Michał Żuchowski, Dominika Mańdziuk, Klaudia Kołodziej, Wojciech Kołodziej
Publikováno v:
Quality in Sport, Vol 15 (2024)
Crigler-Najjar syndrome is an autosomal recessive genetic disorder characterized by a mutation in the UGT1A1 gene, resulting in a complete deficiency of uridine diphosphate glucuronosyltransferase enzyme in hepatocytes. This leads to jaundice due to
Externí odkaz:
https://doaj.org/article/e534b70c7c3e44389283f40182194fcf