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Akademický článek

Targeting cancer’s sweet spot: UGP2 as a therapeutic vulnerability

Autor: Sunghoon Kim, Andrew Wolfe, Sung Eun Kim

Publikováno v: Molecular & Cellular Oncology, Vol 8, Iss 6 (2021)

Understanding the mechanisms governing metabolic reprogramming that underlie potential vulnerabilities in cancer cells is key to developing novel therapeutic strategies. The catalytic enzyme UDP-glucose pyrophosphorylase 2 (UGP2) drives the productio

Externí odkaz: https://doaj.org/article/ca29fb64432a48189ca783dcec520c93

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Akademický článek

Study on the Hepatoprotection of Schisandra chinensis Caulis Polysaccharides in Nonalcoholic Fatty Liver Disease in Rats Based on Metabolomics

Autor: Yanbo Feng, Han Li, Cong Chen, Hao Lin, Guangyu Xu, He Li, Chunmei Wang, Jianguang Chen, Jinghui Sun

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

The aim of this study was to investigate the hepatoprotection of Schisandra chinensis Caulis polysaccharides (SCPs) in the nonalcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD) in rats. A total of 30 Wistar rats were randomly divide

Externí odkaz: https://doaj.org/article/e0320c2c594f4c7fb74d8e241068587e

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Akademický článek

Expression of UGP2 and CFL1 expression levels in benign and malignant pancreatic lesions and their clinicopathological significance

Autor: Lingxiang Wang, Li Xiong, Zhengchun Wu, Xiongying Miao, Ziru Liu, Daiqiang Li, Qiong Zou, Zhulin Yang

Publikováno v: World Journal of Surgical Oncology, Vol 16, Iss 1, Pp 1-9 (2018)

Abstract Background This study investigated UGP2 (uridine diphosphate-glucose pyrophosphorylase-2) and CFL1 (cofilin-1) expression in pancreatic ductal carcinoma (PDC), paracancerous tissue (PT), benign lesions (BL), and normal tissue (NT) and their

Externí odkaz: https://doaj.org/article/43962a3865a44e53a3aee11b9f452e6f

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Akademický článek

Discovery of Novel Inhibitors Targeting Multi-UDP-hexose Pyrophosphorylases as Anticancer Agents

Autor: Yueqin Yang, Hariprasad Vankayalapati, Manshu Tang, Yingbo Zheng, Yingri Li, Cong Ma, Kent Lai

Publikováno v: Molecules, Vol 25, Iss 3, p 645 (2020)

To minimize treatment toxicities, recent anti-cancer research efforts have switched from broad-based chemotherapy to targeted therapy, and emerging data show that altered cellular metabolism in cancerous cells can be exploited as new venues for targe

Externí odkaz: https://doaj.org/article/e37272f890a441639bcb364654c0512e

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Akademický článek

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Inborn errors of metabolite repair

Autor: Guido T. Bommer, Maria Veiga-da-Cunha, Emile Van Schaftingen

Publikováno v: Journal of Inherited Metabolic Disease

It is traditionally assumed that enzymes of intermediary metabolism are extremely specific and that this is sufficient to prevent the production of useless and/or toxic side‐products. Recent work indicates that this statement is not entirely correc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea45d9ed6879fd3fb9480906f71a758
https://doi.org/10.1002/jimd.12187

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Molecular & Cellular Proteomics

Autor: James E. Goldman, Alice Tang, Michelle L. Olsen, Natasha L. Pacheco, Jiangtao Li, Daniel Flint, Brett S. Phinney, Anthony W. Herren, Fatima Khan, Michael R. Heaven

Publikováno v: Molecular & cellular proteomics : MCP, vol 21, iss 1
Molecular & Cellular Proteomics : MCP

Alexander disease (AxD) is a rare and fatal neurodegenerative disorder caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). In this report, a mouse model of AxD (GFAPTg;Gfap+/R236H) was analyzed that contains a heterozygou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27db73f1a1ae5cb5705d0a860adbda89
https://hdl.handle.net/10919/111277

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Study on the Hepatoprotection of Schisandra chinensis Caulis Polysaccharides in Nonalcoholic Fatty Liver Disease in Rats Based on Metabolomics

Autor: He Li, Chunmei Wang, Han Li, Yanbo Feng, Hao Lin, Cong Chen, Jinghui Sun, Jianguang Chen, Guangyu Xu

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5fb9e13be21118b60446a99321681f1
https://www.frontiersin.org/articles/10.3389/fphar.2021.727636/full

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UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth

Autor: Sourav Bandyopadhyay, Maurizio Scaltriti, Qingwen Zhou, Angel A. Ku, Richard Koche, Sung Eun Kim, Jacqueline Galeas, Eneda Toska, Carlito B. Lebrilla, Frank McCormick, Andrew Wolfe

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 31

Significance Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and is one of the most deadly cancer types, with a 5-y survival rate below 10%. One reason for this high mortality rate is that PDAC cells have an enhan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433e879459b718cf5c1514c82422a71a
https://pubmed.ncbi.nlm.nih.gov/34330832

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