Zobrazeno 1 - 10
of 258
pro vyhledávání: '"UELI SUTER"'
Autor:
Daniel Gerber, Jorge A Pereira, Joanne Gerber, Ge Tan, Slavica Dimitrieva, Emilio Yángüez, Ueli Suter
Publikováno v:
eLife, Vol 10 (2021)
Peripheral nerves are organ-like structures containing diverse cell types to optimize function. This interactive assembly includes mostly axon-associated Schwann cells, but also endothelial cells of supporting blood vessels, immune system-associated
Externí odkaz:
https://doaj.org/article/0a0331ff455e4b589c7e42dea7d70f95
Autor:
Vadims Parfejevs, Julien Debbache, Olga Shakhova, Simon M. Schaefer, Mareen Glausch, Michael Wegner, Ueli Suter, Una Riekstina, Sabine Werner, Lukas Sommer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
The peripheral nervous system has been implicated in wound healing. Here, Parfejevs and colleagues report that cutaneous wounding in mice induces the de-differentiation and proliferation of Schwann cells, which disseminate into the wound bed, secrete
Externí odkaz:
https://doaj.org/article/91d26ea46e384fdb9e27908430c6b644
Autor:
Penelope Dimas, Laura Montani, Jorge A Pereira, Daniel Moreno, Martin Trötzmüller, Joanne Gerber, Clay F Semenkovich, Harald C Köfeler, Ueli Suter
Publikováno v:
eLife, Vol 8 (2019)
Oligodendrocytes (OLs) support neurons and signal transmission in the central nervous system (CNS) by enwrapping axons with myelin, a lipid-rich membrane structure. We addressed the significance of fatty acid (FA) synthesis in OLs by depleting FA syn
Externí odkaz:
https://doaj.org/article/30818b9d0b1445eaa84646e39fc7a4ee
Autor:
Daniel Gerber, Monica Ghidinelli, Elisa Tinelli, Christian Somandin, Joanne Gerber, Jorge A Pereira, Andrea Ommer, Gianluca Figlia, Michaela Miehe, Lukas G Nägeli, Vanessa Suter, Valentina Tadini, Páris NM Sidiropoulos, Carsten Wessig, Klaus V Toyka, Ueli Suter
Publikováno v:
eLife, Vol 8 (2019)
Myelination requires extensive plasma membrane rearrangements, implying that molecules controlling membrane dynamics play prominent roles. The large GTPase dynamin 2 (DNM2) is a well-known regulator of membrane remodeling, membrane fission, and vesic
Externí odkaz:
https://doaj.org/article/af9ab6773f8547549f402cbb9cb83ae6
Autor:
Ruani N. Fernando, Laurent Cotter, Claire Perrin-Tricaud, Jade Berthelot, Sylvain Bartolami, Jorge A. Pereira, Sergio Gonzalez, Ueli Suter, Nicolas Tricaud
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Molecular mechanisms regulating optimal myelin geometry are only partially understood. Here authors show that peripheral myelin growth is orchestrated by the Crb3/Hippo/YAP pathway, and that defects in YAP activation may underlie peripheral neuropath
Externí odkaz:
https://doaj.org/article/c1f6ad2ca61c49ab91342b2741d1490a
Publikováno v:
eLife, Vol 6 (2017)
Myelination is a biosynthetically demanding process in which mTORC1, the gatekeeper of anabolism, occupies a privileged regulatory position. We have shown previously that loss of mTORC1 function in Schwann cells (SCs) hampers myelination. Here, we ge
Externí odkaz:
https://doaj.org/article/e06f57a1fa234dac92afd07ce257872d
mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells
Autor:
Camilla Norrmén, Gianluca Figlia, Frédéric Lebrun-Julien, Jorge A. Pereira, Martin Trötzmüller, Harald C. Köfeler, Ville Rantanen, Carsten Wessig, Anne-Lieke F. van Deijk, August B. Smit, Mark H.G. Verheijen, Markus A. Rüegg, Michael N. Hall, Ueli Suter
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 646-660 (2014)
Myelin formation during peripheral nervous system (PNS) development, and reformation after injury and in disease, requires multiple intrinsic and extrinsic signals. Akt/mTOR signaling has emerged as a major player involved, but the molecular mechanis
Externí odkaz:
https://doaj.org/article/677b90a5bd884046a089d5708da8bdeb
Autor:
Sara Ribeiro, Ilaria Napoli, Ian J. White, Simona Parrinello, Adrienne M. Flanagan, Ueli Suter, Luis F. Parada, Alison C. Lloyd
Publikováno v:
Cell Reports, Vol 5, Iss 1, Pp 126-136 (2013)
Schwann cells are highly plastic cells that dedifferentiate to a progenitor-like state following injury. However, deregulation of this plasticity, may be involved in the formation of neurofibromas, mixed-cell tumors of Schwann cell (SC) origin that a
Externí odkaz:
https://doaj.org/article/2bddeaf657e044ad9dcbe1ebb98bb594
Publikováno v:
Neurobiology of Disease, Vol 36, Iss 3, Pp 509-520 (2009)
Mutations in the GDAP1 gene lead to recessively or dominantly inherited peripheral neuropathies (Charcot–Marie–Tooth disease; CMT). Here, we demonstrate that GDAP1 is a mitochondrial fission factor whose activity is dependent on the fission facto
Externí odkaz:
https://doaj.org/article/115210cce251430dba2202d4901ba03a
Autor:
Frédéric Lebrun-Julien, Ueli Suter
Publikováno v:
ASN Neuro, Vol 7 (2015)
Histones deacetylases (HDACs), besides their function as epigenetic regulators, deacetylate and critically regulate the activity of nonhistone targets. In particular, HDACs control partially the proapoptotic activity of p53 by balancing its acetylati
Externí odkaz:
https://doaj.org/article/97a3e00ba09948c38aff79122f2b1257