Výsledky vyhledávání - "UDP, uridine diphosphate"

Ginsenosides in Panax genus and their biosynthesis

Autor: Zhengtao Wang, Shujuan Zhao, Rufeng Wang, Maoqi Hou

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1813-1834 (2021)
Acta Pharmaceutica Sinica. B

Ginsenosides are a series of glycosylated triterpenoids which belong to protopanaxadiol (PPD)-, protopanaxatriol (PPT)-, ocotillol (OCT)- and oleanane (OA)-type saponins known as active compounds of Panax genus. They are accumulated in plant roots, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3ebd6a887266674e75c6007dc0b127
https://doi.org/10.1016/j.apsb.2020.12.017

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Purinergic signaling in infectious diseases of the central nervous system

Autor: Raíssa Leite-Aguiar, Joyce Pereira da Silva, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva, Vinícius Santos Alves

Publikováno v: Brain, Behavior, and Immunity

Highlights • Purinergic signaling is involved in the pathogenesis of neuroinfectious disease. • P2 receptors have pro-inflammatory and deleterious effects in viral Neuroinfections. • ATP-P2X7 receptor signaling contributes to sepsis-associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b36c2eb4e703f769d23badaaa9a5fd
https://doi.org/10.1016/j.bbi.2020.07.026

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Diabetes and hypertension: Pivotal involvement of purinergic signaling

Autor: Vera Maria Morsch, Karine Paula Reichert, Milagros Fanny Vera Castro, Naiara Stefanello, Vanessa Valéria Miron, Andréia Machado Cardoso, Maria Rosa Chitolina Schetinger, Charles Elias Assmann, Nathieli B. Bottari

Publikováno v: Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111273-(2021)
Biomedicine & Pharmacotherapy

Graphical abstract
Highlights • The coexistence of diabetes and hypertension represents a major risk factor for the onset of cardiovascular problems. • The purinergic signaling pathway constitutes a ubiquitous system of cell–cell communica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34db00a41121e428fb7b9d4795d39e99
http://www.sciencedirect.com/science/article/pii/S0753332221000585

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Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2) Is Upregulated in Breast Epithelial–Mesenchymal Transition and Responds to Oxidative Stress

Autor: Qiong Wang, Sigurdur Trausti Karvelsson, Aristotelis Kotronoulas, Thorarinn Gudjonsson, Skarphedinn Halldorsson, Ottar Rolfsson

Publikováno v: Molecular & Cellular Proteomics : MCP

Breast cancer cells that have undergone partial epithelial–mesenchymal transition (EMT) are believed to be more invasive than cells that have completed EMT. To study metabolic reprogramming in different mesenchymal states, we analyzed protein expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a82c97a23a25ba1765695dda58542d
https://doi.org/10.1016/j.mcpro.2021.100185

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Characterization of two enzymes from Psychrobacter cryohalolentis that are required for the biosynthesis of an unusual diacetamido-d-sugar

Autor: James B. Thoden, Hazel M. Holden, Michael P. Linehan

Publikováno v: The Journal of Biological Chemistry

Psychrobacter cryohalolentis strain K5T is a Gram-negative organism first isolated in 2006. It has a complex O-antigen that contains, in addition to l-rhamnose and d-galactose, two diacetamido- and a triacetamido-sugar. The biochemical pathways for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb259a5276ce0c77259bfa77b82692d5
https://doi.org/10.1016/j.jbc.2021.100463

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Isolation and analysis of sugar nucleotides using solid phase extraction and fluorophore assisted carbohydrate electrophoresis

Autor: Liping Tian, Suzy A. A. Comhair, James Hiznay, Jarrod W. Barnes, Jacqueline Loftis, Raed A. Dweik, Mark E. Lauer

Publikováno v: MethodsX

Graphical abstract
The building blocks of simple and complex oligosaccharides, termed sugar nucleotides, are often overlooked for their role in metabolic diseases and may hold the key to the underlying disease pathogenesis. Multiple reasons may

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Effects of antibiotic antitumor drugs on nucleotide levels in cultured tumor cells: an exploratory method to distinguish the mechanisms of antitumor drug action based on targeted metabolomics

Autor: Lixin Sun, Xi Liu, Zheng Liu, Cuichai Liu, Fang Wang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 5, Iss 3, Pp 223-230 (2015)

Nucleotide pools in mammalian cells change due to the influence of antitumor drugs, which may help in evaluating the drug effect and understanding the mechanism of drug action. In this study, an ion-pair RP-HPLC method was used for a simple, sensitiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4570a8b7fa77c93ff61bd2d9a519b1
https://pubmed.ncbi.nlm.nih.gov/26579450

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Prospects for novel inhibitors of peptidoglycan transglycosylases

Autor: Nicola F, Galley, Amy M, O'Reilly, David I, Roper

Publikováno v: Bioorganic Chemistry

Highlights • We examine key aspects of transglycosylase inhibitor design. • Low to high throughput assays suitable for transglycosylase drug discovery. • Existing chemical start points for transglycosylase active site targeting.
The lack o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3744a665d5ce550e5a4bdb5ba3683d8
https://pubmed.ncbi.nlm.nih.gov/24924926

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UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib

Autor: Landmann, H, Proia, D A, He, S, Ogawa, L S, Kramer, F, Beißbarth, T, Grade, M, Gaedcke, J, Ghadimi, M, Moll, U, Dobbelstein, M

Publikováno v: Cell Death & Disease

HSP90 inhibition represents a promising route to cancer therapy, taking advantage of cancer cell-inherent proteotoxic stress. The HSP90-inhibitor ganetespib showed benefit in advanced clinical trials. This raises the need to identify the molecular de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1418fee028c3437ec5a62f50d55a7664
http://resolver.sub.uni-goettingen.de/purl?gs-1/10891

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Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target

Autor: Daan M. F. van Aalten, Michael A. J. Ferguson, Wenxia Fang, Karina Mariño, Ramon Hurtado-Guerrero, Osama Albarbarawi, Cheng Jin, Olawale G. Raimi, Adel F. M. Ibrahim, Ting-Ting Du

Publikováno v: Scopus-Elsevier
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Bioscience Reports, Vol 33, Iss 5, p e00063 (2013)
Bioscience Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

11 pags, 5 figs, 3 tabs
Synopsis Aspergillus fumigatus is the causative agent of IA (invasive aspergillosis) in immunocompromised patients. It possesses a cell wall composed of chitin, glucan and galactomannan, polymeric carbohydrates synthesize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8217806f50a6dea28945eef3170632
http://hdl.handle.net/10261/244786

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