Zobrazeno 1 - 10
of 843
pro vyhledávání: '"UCHL1"'
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-19 (2024)
Abstract Background Triple-negative breast cancer (TNBC) is characterized by high invasiveness and metastasis potential. Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is strongly associated with breast cancer progression, although the underlying me
Externí odkaz:
https://doaj.org/article/69f2616416fc4e3fb19f0687e3819027
Autor:
Jing Duan, Aowei Lv, Zhen Guo, Qi Liu, Chen Tian, Ying Yang, Jin Bi, Xintong Yu, Guoping Peng, Benyan Luo, Zhijian Cai, Bin Xu, Ying Fu, Jing Zhang
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract In neuroinflammation, distinguishing microglia from macrophages and identifying microglial-specific biomarkers in peripheral blood pose significant challenges. This study comprehensively profiled the extracellular vesicles (EVs) of microglia
Externí odkaz:
https://doaj.org/article/d89f5cdfc7ea439d8c1d87b312be5bd5
Autor:
Chi Young Kim, Eun Hye Lee, Se Hyun Kwak, Sang Hoon Lee, Eun Young Kim, Min Kyoung Park, Yoon Jin Cha, Yoon Soo Chang
Publikováno v:
Tuberculosis and Respiratory Diseases, Vol 87, Iss 4, Pp 494-504 (2024)
Background Ubiquitin C-terminal hydrolase L1 (UCHL1), which encodes thiol protease that hydrolyzes a peptide bond at the C-terminal glycine residue of ubiquitin, regulates cell differentiation, proliferation, transcriptional regulation, and numerous
Externí odkaz:
https://doaj.org/article/de99a47c47ca4f60baa8aef2e08e576c
Autor:
Scott B. Ficarro, Zachary H. Marto, Nicholas M. Girardi, Dingyu Deng, Isabella Jaen Maisonet, Guillaume Adelmant, Laura E. Fleming, Mona Sharafi, Isidoro Tavares, Andrew Zhao, HyoJeon Kim, Hyuk-Soo Seo, Sirano Dhe-Paganon, Sara J. Buhrlage, Jarrod A. Marto
Publikováno v:
SLAS Discovery, Vol 29, Iss 8, Pp 100198- (2024)
Target-based screening of covalent fragment libraries with mass spectrometry has emerged as a powerful strategy to identify chemical starting points for small molecule inhibitors or find new binding pockets on proteins of interest. These libraries sp
Externí odkaz:
https://doaj.org/article/4332138746db43fda20fad84946e548d
Autor:
Shengjie Shi, Huan Yuan, Lutong Zhang, Lei Gao, Lili Zhao, Xiangfang Zeng, Shiyan Qiao, Guiyan Chu, Chuanjiang Cai
Publikováno v:
Journal of Animal Science and Biotechnology, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background The proliferation of porcine ovarian granulosa cells (GCs) is essential to follicular development and the ubiquitin–proteasome system is necessary for maintaining cell cycle homeostasis. Previous studies found that the deubiquit
Externí odkaz:
https://doaj.org/article/2253e0a7c8d44a789bce741bea052f97
Autor:
Jie Zhang, Mingxing Xue, Jiefang Huang, Shan He, Lingqiao Zhu, Xiaonan Zhao, Bei Wang, Tingwang Jiang, Yanyun Zhang, Changhong Miao, Guoqiang Zhou
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Miscarriage is a frustrating complication of pregnancy that is common among women of reproductive age. Insufficient decidualization which not only impairs embryo implantation but disturbs fetomaternal immune-tolerance, has been wi
Externí odkaz:
https://doaj.org/article/4471b49fb439424694c445244d5998b4
Autor:
Jie Cheng, Hanqing Liu, Yan Shen, Jiawei Ding, Hongchao He, Shilong Mao, Li Chen, Chuanjie Zhang, Jian Zhou
Publikováno v:
Translational Oncology, Vol 45, Iss , Pp 101987- (2024)
Background: Bevacizumab resistance poses barriers to targeted therapy in clear cell renal cell carcinoma (ccRCC). Whether there exist epigenetic targets that modulate bevacizumab sensitivity in ccRCC remains indefinite. The focus of this study is to
Externí odkaz:
https://doaj.org/article/0768daf21a564f3090cb8120882adf5d
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-15 (2024)
Abstract Background Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that regulates ERα expression in triple-negative cancer (TNBC). This study aimed to explore the deubiquitination substrates of UCHL1 related to endocri
Externí odkaz:
https://doaj.org/article/8114d1c29c9742ba9e3d9518415e6f37
Autor:
Natalia Niedziela, Maria Nowak-Kiczmer, Lina Malciene, Mariusz Stasiołek, Jolanta Zalejska-Fiolka, Zenon P. Czuba, Jacek T. Niedziela, Jarosław Szczygieł, Michał Lubczyński, Monika Adamczyk-Sowa
Publikováno v:
Diagnostics, Vol 14, Iss 17, p 1993 (2024)
Background: Inflammatory demyelination and impaired recovery processes result in permanent neurodegeneration and neurological disability in patients with multiple sclerosis (MS). In terms of smoldering MS, chronic neuroinflammation develops in the ea
Externí odkaz:
https://doaj.org/article/61ebab41b67a4f33ba58224a65613e3b
Autor:
Yeon Ju Kim, In Hye Jeong, Jung Ho Ha, Young Sun Kim, Siung Sung, Jeong Hun Jang, Yun-Hoon Choung
Publikováno v:
Cells, Vol 13, Iss 9, p 737 (2024)
In mammals, hearing loss is irreversible due to the lack of the regenerative capacity of the auditory epithelium. However, stem/progenitor cells in mammalian cochleae may be a therapeutic target for hearing regeneration. The ubiquitin proteasome syst
Externí odkaz:
https://doaj.org/article/9712882e0d274ec88b667ace5b7aa790