Zobrazeno 1 - 10
of 333
pro vyhledávání: '"UBQLN2"'
Autor:
Sang Hwa Kim, Kye D Nichols, Eric N Anderson, Yining Liu, Nandini Ramesh, Weiyan Jia, Connor J Kuerbis, Mark Scalf, Lloyd M Smith, Udai Bhan Pandey, Randal S Tibbetts
Publikováno v:
eLife, Vol 12 (2023)
Mutations in the ubiquitin (Ub) chaperone Ubiquilin 2 (UBQLN2) cause X-linked forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) through unknown mechanisms. Here, we show that aggregation-prone, ALS-associated mutants of U
Externí odkaz:
https://doaj.org/article/72192ff0353948d194af3bd44b77dd3a
Autor:
Peter S. McPherson, Ian McDowell, Carl Laflamme, Kathleen Southern, Riham Ayoubi, Maryam Fotouhi
Publikováno v:
F1000Research, Vol 12 (2023)
Ubiquilin-2, a member of the ubiquilin protein family, plays a role in the regulation of various protein degradation pathways, and is mutated in some neurodegenerative diseases. Well-characterized anti-Ubiquilin-2 antibodies would advance reproducibl
Externí odkaz:
https://doaj.org/article/ad377a83880d4ddfb58879438a9e29e9
Autor:
Holly H Black, Jessica L Hanson, Julia E Roberts, Shannon N Leslie, Will Campodonico, Christopher C Ebmeier, G Aaron Holling, Jian Wei Tay, Autumn M Matthews, Elizabeth Ung, Cristina I Lau, Alexandra M Whiteley
Publikováno v:
eLife, Vol 12 (2023)
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron dysfunction and loss. A portion of ALS cases are caused by mutation of the proteasome shuttle factor Ubiquilin 2 (UBQLN2), but the mole
Externí odkaz:
https://doaj.org/article/496be42dc5534e3d8968e84acdbd3556
Autor:
Parag P. Shah, Kumar Saurabh, Zimple Kurlawala, Alexis A. Vega, Leah J. Siskind, Levi J. Beverly
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 25, Iss , Pp 1-8 (2022)
The Ubiquilin family of proteins (UBQLN) consists of five related proteins (UBQLN1-4 and UBQLNL) that all contain ubiquitin-like (UBL) and ubiquitin-associated (UBA) domains. UBQLN1 and UBQLN2 are the most closely related and have been the most well-
Externí odkaz:
https://doaj.org/article/35bad9dce328456ea3a918631c3ac99b
Akademický článek
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Autor:
Parag P. Shah, Levi J. Beverly
Publikováno v:
Cancers, Vol 15, Iss 13, p 3389 (2023)
The ubiquilin family (UBQLN) of proteins consists of five closely related members (UBQLN1, UBQLN2, UBQLN3, UBQLN4, and UBQLNL) that have a high degree of similarity at the level of both amino acid and domain structure. The role of UBQLN1 and UBQLN2 i
Externí odkaz:
https://doaj.org/article/ac0ae9efa8a140bba5e0cb090008aed6
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract Missense mutations in UBQLN2 cause X-linked dominant inheritance of amyotrophic lateral sclerosis with frontotemporal dementia (ALS/FTD). UBQLN2 belongs to a family of four highly homologous proteins expressed in humans that play diverse rol
Externí odkaz:
https://doaj.org/article/0fcaba42c1b74b49bb6f46fc339a3d9e
Autor:
Yuan‐Deng Luo, Hong‐Qiang Yu, Xiao‐Yu Liu, Deng Huang, Hai‐Su Dai, Lei Fang, Yu‐Jun Zhang, Jie‐Juan Lai, Yan Jiang, Ling Shuai, Lei‐Da Zhang, Geng Chen, Ping Bie, Chuan‐Ming Xie
Publikováno v:
Cancer Medicine, Vol 9, Iss 12, Pp 4083-4094 (2020)
Abstract Purpose Hepatocellular carcinoma (HCC) is a common malignant cancer and the third leading cause of death worldwide. The molecular mechanism of HCC remains unclear. Recent studies have demonstrated that the ubiquitin‐proteasome system (UPS)
Externí odkaz:
https://doaj.org/article/3acd50238a3f44eaba329814ac32cc5f
Autor:
Sharkey, Lisa M., Safren, Nathaniel, Pithadia, Amit S., Gerson, Julia E., Dulchavsky, Mark, Fischer, Svetlana, Patel, Ronak, Lantis, Gabrielle, Ashraf, Naila, Kim, John H., Meliki, Alia, Minakawa, Eiko N., Barmada, Sami J., Ivanova, Magdalena I., Paulson, Henry L.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Oct . 115(44), E10495-E10504.
Externí odkaz:
https://www.jstor.org/stable/26532475
Akademický článek
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