Zobrazeno 1 - 10
of 35 916
pro vyhledávání: '"UBIQUITIN LIGASE"'
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 5615-5639 (2024)
Chunyan Weng,1,* Rijuan Jin,1,* Xiaoliang Jin,1,* Zimei Yang,1,* Chenghai He,1,2 Qiuhua Zhang,1 Jingli Xu,1,3 Bin Lv1 1Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Prov
Externí odkaz:
https://doaj.org/article/aafe34663c9f41f28eabffa1e2ea0689
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-26 (2024)
Abstract Loss-of-function mutations in the human gene encoding the neuron-specific Ca2+ channel CaV2.1 are linked to the neurological disease episodic ataxia type 2 (EA2), as well as neurodevelopmental disorders such as developmental delay and develo
Externí odkaz:
https://doaj.org/article/c101447efafa40999fb74b6482cc9c59
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Ubiquitination is a prevalent post-translational modification that plays a crucial role in a wide range of pathophysiological processes, including cell proliferation, apoptosis, autophagy, immune response, and DNA damage repair. Among the en
Externí odkaz:
https://doaj.org/article/508f688ea0c14db1a507bbf6970c6d87
Publikováno v:
Shipin Kexue, Vol 45, Iss 20, Pp 280-289 (2024)
Protein ubiquitination, an important post-translational modification, plays a wide role in the life activities of eukaryotic cells. E3 ubiquitin ligases specifically recognize target proteins in the ubiquitin-proteasome degradation system and play a
Externí odkaz:
https://doaj.org/article/f7f4447229494da3930026e876733108
Publikováno v:
Xibei zhiwu xuebao, Vol 44, Iss 9, Pp 1411-1419 (2024)
[Objective] The study aims to explore the role of TaRING1 in the interaction between wheat and stripe rust, analyze its mechanism and provide theoretical basis for the green prevention and control of wheat stripe rust. [Methods] The interaction tar
Externí odkaz:
https://doaj.org/article/09ea0b282f344a309397d6165ac81b2d
Autor:
ZHANG Runmei, WU Fengzhang
Publikováno v:
Xibei zhiwu xuebao, Vol 44, Iss 9, Pp 1420-1432 (2024)
Abstract [Objective] This study aims to explore the function of VuARI2 gene in response to low temperature stress, by cloning and expressing VuARI2 gene in Arabidopsis. [Methods] VuARI2 gene was cloned from the stem of bog bilberry by RACE and RT-P
Externí odkaz:
https://doaj.org/article/6fb94ee0e1e5417294bec290b5d81746
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-6 (2024)
Abstract The PDZ-LIM domain-containing protein PDLIM2 is a common tumor suppressor and a key immune modulator. One main function of PDLIM2 is to promote the ubiquitination and proteasomal degradation of nuclear activated NF-κB RelA, a physiologicall
Externí odkaz:
https://doaj.org/article/8c1702ee06b2478bb67adc94a80ef627
Publikováno v:
eLife, Vol 13 (2024)
The development of proteolysis targeting chimeras (PROTACs), which induce the degradation of target proteins by bringing them into proximity with cellular E3 ubiquitin ligases, has revolutionized drug development. While the human genome encodes more
Externí odkaz:
https://doaj.org/article/6ebd71dcf0384a5ca00c736d20c97618
Autor:
Ashley P. Dudey, Jake M. Rigby, Gregory R. Hughes, G. Richard Stephenson, Thomas E. Storr, Andrew Chantry, Andrew M. Hemmings
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
The HECT E3 ubiquitin ligases 1 (WWP1) and 2 (WWP2) are responsible for the ubiquitin-mediated degradation of key tumour suppressor proteins and are dysregulated in various cancers and diseases. Here we expand their limited inhibitor space by identif
Externí odkaz:
https://doaj.org/article/9ea481d25ddf466492f4e323196ebb63