Zobrazeno 1 - 10
of 535
pro vyhledávání: '"UBIQUITIN E3 LIGASE"'
Autor:
Adam J. Fletcher, Peter D. Mabbitt
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/5802f57c7a7b40408e8648683205b378
Autor:
Lana Buzuk, Doris Hellerschmied
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The Golgi apparatus is an essential organelle of the secretory pathway in eukaryotic cells. It processes secretory and transmembrane proteins and orchestrates their transport to other endomembrane compartments or the plasma membrane. The Golgi appara
Externí odkaz:
https://doaj.org/article/d2f000f564c04a999faccb07ae0b3f79
Autor:
Xiaohua Lou, Binbin Ma, Yuan Zhuang, Xiang Xiao, Laurie J. Minze, Junji Xing, Zhiqiang Zhang, Xian C. Li
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4921-4929 (2022)
Protein ubiquitination plays a vital role in controlling the degradation of intracellular proteins and in regulating cell signaling pathways. Functionally, E3 ubiquitin ligases control the transfer of ubiquitin to the target substrates. As a major fa
Externí odkaz:
https://doaj.org/article/b3e6fbc3ac5a4892b6288d8bf44ecb3b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Ubiquitination is a critical type of protein post-translational modification playing an essential role in many cellular processes. To date, more than eight types of ubiquitination exist, all of which are involved in distinct cellular processes based
Externí odkaz:
https://doaj.org/article/23718255bf5e4992b3e9c6ecd4c7a047
Autor:
M. Lienhard Schmitz, Jan Dreute, Maximilian Pfisterer, Stefan Günther, Michael Kracht, Shashipavan Chillappagari
Publikováno v:
Heliyon, Vol 8, Iss 3, Pp e09029- (2022)
The functionally redundant ubiquitin E3 ligases SIAH1 and SIAH2 have been implicated in the regulation of metabolism and the hypoxic response, while their role in other signal-mediated processes such inflammatory gene expression remains to be defined
Externí odkaz:
https://doaj.org/article/993a3b9a555747aa87ad6b70bfc74e1f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Ubiquitination is a posttranslational modification of proteins that significantly affects protein stability and function. The specificity of substrate recognition is determined by ubiquitin E3 ligase during ubiquitination. Human Deltex (DTX) protein
Externí odkaz:
https://doaj.org/article/475cdea34ee24571887f9e6b7198e493
Publikováno v:
Journal of Biomedical Science, Vol 26, Iss 1, Pp 1-12 (2019)
Abstract Autophagy is a major degradation pathway that utilizes lysosome hydrolases to degrade cellular constituents and is often induced under cellular stress conditions to restore cell homeostasis. Another prime degradation pathway in the cells is
Externí odkaz:
https://doaj.org/article/d7f188eff41045d1a04b744e06a52c8d
Publikováno v:
Frontiers in Plant Science, Vol 12 (2021)
Protein quality control (PQC) is essential for maintaining cellular homeostasis by reducing protein misfolding and aggregation. Major PQC mechanisms include protein refolding assisted by molecular chaperones and the degradation of misfolded and aggre
Externí odkaz:
https://doaj.org/article/1dc0e7ecaf4d46ca81dcfc5c046c675e
Autor:
Guoqing Zhu, Feng Wang, Haojie Li, Xiao Zhang, Qi Wu, Ya Liu, Mingping Qian, Susu Guo, Yueyue Yang, Xiangfei Xue, Fenyong Sun, Yongxia Qiao, Qiuhui Pan
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundA tremendous amount of studies have suggested that post-translational modifications (PTMs) play pivotal roles during tumorigenesis. Compared to other PTMs, lipid modification is less studied. Recently, N-myristoylation, one type of lipid mo
Externí odkaz:
https://doaj.org/article/d71e23de8adc4b5396d1067a5bcefac7
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Activation of NF-κB transcription factors is critical for innate immune cells to induce inflammation and fight against microbial pathogens. On the other hand, the excessive and prolonged activation of NF-κB causes massive inflammatory damage to the
Externí odkaz:
https://doaj.org/article/539891c83bb74a5babb081811dc287ef