Zobrazeno 1 - 8
of 8
pro vyhledávání: '"U. W. Kleef"'
Autor:
M. C. Houwertjes, T. M. Beaufort, U. W. Kleef, J. M. K. H. Wierda, K. Kuizenga, Johannes H. Proost
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 27:173-190
In pharmacokinetic/pharmacodynamic (PK/PD) modeling the first blood sample is usually taken 1 to 2 min after drug administration (late sampling). Therefore, investigators have to extrapolate the plasma concentration to Time 0. Extrapolation, however,
Publikováno v:
Canadian Journal of Anaesthesia. 41:213-220
Three muscle relaxants, Org 9453, Org 9489 and Org 9487, short-acting in animals, were investigated to establish their profiles in humans. Potency, time course of action, and pharmacokinetic behaviour were studied in 90 healthy patients during fentan
Publikováno v:
Canadian journal of anaesthesia-Journal canadien d anesthesie, 38(4), 430-435. SPRINGER
The pharmacodynamics and pharmacokinetics of a new non-depolarizing neuromuscular blocking agent, Org 9426, were investigated. Ten patients undergoing elective head and neck surgery and anaesthetized with nitrous oxide, halothane and fentanyl, receiv
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 27(2)
In pharmacokinetic/pharmacodynamic (PK/PD) modeling the first blood sample is usually taken 1 to 2 min after drug administration (late sampling). Therefore, investigators have to extrapolate the plasma concentration to Time 0. Extrapolation, however,
Publikováno v:
European journal of anaesthesiology. Supplement. 11
Hypothermia prolongs the time-course of action of non-depolarizing neuromuscular blocking agents. The mechanism, however, is unknown. We studied the influence of hypothermia (by surface cooling, nasopharyngeal temperatureor = 31 degrees C) on the tim
Publikováno v:
Anesthesia and analgesia. 77(6)
To determine the effect of liver cirrhosis on the pharmacokinetics and pharmacodynamics of pipecuronium, the authors administered 100 micrograms/kg of pipecuronium intravenously to eight patients with liver cirrhosis and eight patients with normal li
Autor:
J M, Wierda, J, Szenohradszky, A P, De Wit, G, Zentai, S, Agoston, M, Kakas, U W, Kleef, D K, Meijer
Publikováno v:
European journal of anaesthesiology. 8(6)
The pharmacodynamics and -kinetics of pipecuronium were studied in 12 patients, six of whom received 100 micrograms kg-1 for laryngectomy (Group L), and six who underwent choledochotomy after insertion of the T-drain and were given 50 micrograms kg-1
Autor:
H. J. van der Molen, U. W. Kleef
Publikováno v:
Acta Endocrinologica. 41:247-258
The occurrence, metabolic formation and degradation of 5β-pregnan-3α-ol-20-one are reviewed. Estimation of 5β-pregnan-3α-ol-20-one in urine has shown that: under acid conditions 5β-pregnane-3α,17α,20α-triol is destroyed with partial formation