Structure-based design and characterization of Parkin activating mutations

Autor: Michael U. Stevens, Nathalie Croteau, Mohamed A. Eldeeb, Zhi Wei Zeng, Rachel Toth, Thomas M. Durcan, Wolfdieter Springer, Edward A. Fon, Miratul M. K. Muqit, Jean-François Trempe

Human autosomal recessive mutations in the Parkin gene are causal for Parkinson’s disease (PD). Parkin encodes a ubiquitin E3 ligase that functions together with the PD associated kinase, PINK1, in a mitochondrial quality control pathway. Structura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e3b95cc902b0112b483418631ee38f0
https://doi.org/10.1101/2022.02.22.481412

Science Goals and Mission Architecture of the Europa Lander Mission Concept

Autor: K. P. Hand, C. B. Phillips, A. Murray, J. B. Garvin, E. H. Maize, R. G. Gibbs, G. Reeves, A. M. San Martin, G. H. Tan-Wang, J. Krajewski, K. Hurst, R. Crum, B. A. Kennedy, T. P. McElrath, J. C. Gallon, D. Sabahi, S. W. Thurman, B. Goldstein, P. Estabrook, S. W. Lee, J. A. Dooley, W. B. Brinckerhoff, K. S. Edgett, C. R. German, T. M. Hoehler, S. M. Hörst, J. I. Lunine, C. Paranicas, K. Nealson, D. E. Smith, A. S. Templeton, M. J. Russell, B. Schmidt, B. Christner, B. Ehlmann, A. Hayes, A. Rhoden, P. Willis, R. A. Yingst, K. Craft, M. E. Cameron, T. Nordheim, J. Pitesky, J. Scully, J. Hofgartner, S. W. Sell, K. J. Barltrop, J. Izraelevitz, E. J. Brandon, J. Seong, J.-P. Jones, J. Pasalic, K. J. Billings, J. P. Ruiz, R. V. Bugga, D. Graham, L. A. Arenas, D. Takeyama, M. Drummond, H. Aghazarian, A. J. Andersen, K. B. Andersen, E. W. Anderson, A. Babuscia, P. G. Backes, E. S. Bailey, D. Balentine, C. G. Ballard, D. F. Berisford, P. Bhandari, K. Blackwood, G. S. Bolotin, E. A. Bovre, J. Bowkett, K. T. Boykins, M. S. Bramble, T. M. Brice, P. Briggs, A. P. Brinkman, S. M. Brooks, B. B. Buffington, B. Burns, M. L. Cable, S. Campagnola, L. A. Cangahuala, G. A Carr, J. R. Casani, N. E. Chahat, B. K. Chamberlain-Simon, Y. Cheng, S. A. Chien, B. T. Cook, M. Cooper, M. DiNicola, B. Clement, Z. Dean, E. A. Cullimore, A. G. Curtis, J-P. de la Croix, P. Di Pasquale, E. M. Dodd, L. A. Dubord, J. A. Edlund, R. Ellyin, B. Emanuel, J. T. Foster, A. J. Ganino, G. J. Garner, M. T. Gibson, M. Gildner, K. J. Glazebrook, M. E. Greco, W. M. Green, S. J. Hatch, M. M. Hetzel, W. A. Hoey, A. E. Hofmann, R. Ionasescu, A. Jain, J. D. Jasper, J. R. Johannesen, G. K. Johnson, I. Jun, A. B. Katake, S. Y. Kim-Castet, D. I. Kim, W. Kim, E. F. Klonicki, B. Kobeissi, B. D. Kobie, J. Kochocki, M. Kokorowski, J. A. Kosberg, K. Kriechbaum, T. P. Kulkarni, R. L. Lam, D. F. Landau, M. A. Lattimore, S. L. Laubach, C. R. Lawler, G. Lim, J. Y Lin, T. E. Litwin, M. W. Lo, C. A. Logan, E. Maghasoudi, L. Mandrake, Y. Marchetti, E. Marteau, K. A. Maxwell, J. B. Mc Namee, O. Mcintyre, M. Meacham, J. P. Melko, J. Mueller, D. A. Muliere, A. Mysore, J. Nash, H. Ono, J. M. Parker, R. C. Perkins, A. E Petropoulos, A. Gaut, M. Y. Piette Gomez, R. P. Casillas, M. Preudhomme, G. Pyrzak, J. Rapinchuk, J. M. Ratliff, T. L. Ray, E. T. Roberts, K. Roffo, D. C. Roth, J. A. Russino, T. M. Schmidt, M. J. Schoppers, J. S. Senent, F. Serricchio, D. J. Sheldon, L. R. Shiraishi, J. Shirvanian, K. J. Siegel, G. Singh, A. R. Sirota, E. D. Skulsky, J. S. Stehly, N. J. Strange, S. U. Stevens, E. T. Sunada, S. P. Tepsuporn, L. P. C. Tosi, N. Trawny, I. Uchenik, V. Verma, R. A. Volpe, C. T. Wagner, D. Wang, R. G. Willson, J. L. Wolff, A. T. Wong, A. K. Zimmer, K. G. Sukhatme, K. A. Bago, Y. Chen, A. M. Deardorff, R. S. Kuch, C. Lim, M. L. Syvertson, G. A. Arakaki, A. Avila, K. J. DeBruin, A. Frick, J. R. Harris, M. C. Heverly, J. M. Kawata, S.-K. Kim, D. M. Kipp, J. Murphy, M. W. Smith, M. D. Spaulding, R. Thakker, N. Z. Warner, C. R. Yahnker, M. E. Young, T. Magner, D. Adams, P. Bedini, L. Mehr, C. Sheldon, S. Vernon, V. Bailey, M. Briere, M. Butler, A. Davis, S. Ensor, M. Gannon, A. Haapala-Chalk, T. Hartka, M. Holdridge, A. Hong, J. Hunt, J. Iskow, F. Kahler, K. Murray, D. Napolillo, M. Norkus, R. Pfisterer, J. Porter, D. Roth, P. Schwartz, L. Wolfarth, E. H. Cardiff, E. W. Grob, J. R. Adam, E. Betts, J. Norwood, M. M. Heller, T. Voskuilen, P. Sakievich, L. Gray, D. J. Hansen, K. W. Irick, J. C. Hewson, J. Lamb, S. C. Stacy, C. M. Brotherton, A. S Tappan, D. Benally, H. Thigpen, E. Ortiz, D. Sandoval, A. M. Ison, M. Warren, P. G. Stromberg, P. M. Thelen, B. Blasy, P. Nandy, A. W. Haddad, L. B. Trujillo, T. H. Wiseley, S. A. Bell, N. P. Teske, C. Post, L. Torres-Castro, C. Grosso, M. Wasiolek

Publikováno v: The Planetary Science Journal. 3:22

Europa is a premier target for advancing both planetary science and astrobiology, as well as for opening a new window into the burgeoning field of comparative oceanography. The potentially habitable subsurface ocean of Europa may harbor life, and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cadd7bf8627d10ec8957c64aeb6791b
https://doi.org/10.3847/psj/ac4493

Cardiovascular and thrombogenic risk of decidual vasculopathy in preeclampsia

Autor: D. U. Stevens, Marcela M. Fajta, Marc E. A. Spaanderman, Maureen J. van der Vlugt, Salwan Al-Nasiry, Wim J.G. Oyen, Johan Bulten, Arie P.J. van Dijk, John M. G. van Vugt

Publikováno v: American Journal of Obstetrics and Gynecology, 210, 545.e1-6
American Journal of Obstetrics and Gynecology, 210, 6, pp. 545.e1-6
American Journal of Obstetrics and Gynecology, 210(6):5450. MOSBY-ELSEVIER

Contains fulltext : 133808.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Women with a history of preeclampsia (PE) have an increased prevalence of cardiometabolic, cardiovascular, and prothrombotic risk factors. Remotely, these women are at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99644497e2c7c07da5fdfd3b8e204ea
https://pubmed.ncbi.nlm.nih.gov/24370690

Role of Serial Plasma C.E.A. Assays in Detection of Recurrent and Metastatic Colorectal Carcinomas

Autor: A. M. Mackay, A. M. Neville, Edward H. Cooper, U. Stevens, S. Patel, S. Carter, D. J. R. Laurence

Publikováno v: BMJ. 4:382-385

Serial estimations of plasma carcinoembryonic antigen (C.E.A.) levels have been carried out in 220 patients with colorectal carcinomas who had potentially and apparently curative surgery. In a two-year follow-up period 53 patients developed recurrenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e0dadf94d9b0b00d4df39d25d4ecdc
https://doi.org/10.1136/bmj.4.5941.382

Carcinoembryonic Antigen in the Urine of Patients with Urothelial Carcinoma

Autor: A. Munro Neville, S. Roberts, D. Darcy, R. James, U. Stevens, R. R. Hall, D. J. R. Laurence

Publikováno v: BMJ. 3:609-611

Increased amounts of carcinoembryonic antigen (C.E.A.) or C.E.A.-like material are found in the urine of many patients with transitional cell carcinomas of the bladder, including those presumed to be at an early stage of development. It is suggested

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346f0f68bb46433f3ed31684e2bc3f28
https://doi.org/10.1136/bmj.3.5827.609