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Absence of herb-drug interactions of mistletoe with the tamoxifen metabolite (E/Z)-endoxifen and cytochrome P450 3A4/5 and 2D6 in vitro

Autor: U. Weissenstein, M. Kunz, M. Oufir, J. T. Wang, M. Hamburger, K. Urech, U. Regueiro, S. Baumgartner

Publikováno v: BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-12 (2019)

Abstract Background Women diagnosed with breast cancer frequently seek complementary and alternative (CAM) treatment options that can help to cope with their disease and the side effects of conventional cancer therapy. Especially in Europe, breast ca

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Additional file 7: of Absence of herb-drug interactions of mistletoe with the tamoxifen metabolite (E/Z)-endoxifen and cytochrome P450 3A4/5 and 2D6 in vitro

Autor: U. Weissenstein, M. Kunz, M. Oufir, J. Wang, M. Hamburger, K. Urech, U. Regueiro, S. Baumgartner

Figure S4. Testosterone in vitro inhibition profiles of CYP3A4/5 (VAEP, VAEQu, VAEM). Results are presented as mean rate values Âą SE (from three independent experiments) of 6Î˛-hydroxytestosterone formation in vitro expressed as a percent of the

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Additional file 9: of Absence of herb-drug interactions of mistletoe with the tamoxifen metabolite (E/Z)-endoxifen and cytochrome P450 3A4/5 and 2D6 in vitro

Autor: U. Weissenstein, M. Kunz, M. Oufir, J. Wang, M. Hamburger, K. Urech, U. Regueiro, S. Baumgartner

Figure S6. Testosterone in vitro inhibition profile of CYP3A4/5 by reference inhibitor: Ketoconazole (0.1-1-2-5-10-100 ÎźM). Results are presented as mean rate values Âą SE (from three independent experiments) of 6Î˛-hydroxytestosterone formati

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Additional file 4: of Absence of herb-drug interactions of mistletoe with the tamoxifen metabolite (E/Z)-endoxifen and cytochrome P450 3A4/5 and 2D6 in vitro

Autor: U. Weissenstein, M. Kunz, M. Oufir, J. Wang, M. Hamburger, K. Urech, U. Regueiro, S. Baumgartner

Figure S1. Dextromethorphan in vitro inhibition profiles of CYP2D6 by mistletoe preparations (VAEP, VAEQu, and VAEM). Results are presented as mean rate values Âą SE (from three independent experiments) of dextrorphan formation in vitro expressed a

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Additional file 6: of Absence of herb-drug interactions of mistletoe with the tamoxifen metabolite (E/Z)-endoxifen and cytochrome P450 3A4/5 and 2D6 in vitro

Autor: U. Weissenstein, M. Kunz, M. Oufir, J. Wang, M. Hamburger, K. Urech, U. Regueiro, S. Baumgartner

Figure S3. Dextromethorphan in vitro inhibition profiles of CYP2D6 by reference inhibitor: Quinidine (0.1-1-2-5-10-100 ÎźM). Results are presented as mean rate values Âą SE (from three independent experiments) of dextrorphan formation in vitro ex

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Additional file 5: of Absence of herb-drug interactions of mistletoe with the tamoxifen metabolite (E/Z)-endoxifen and cytochrome P450 3A4/5 and 2D6 in vitro

Autor: U. Weissenstein, M. Kunz, M. Oufir, J. Wang, M. Hamburger, K. Urech, U. Regueiro, S. Baumgartner

Figure S2. Tamoxifen in vitro inhibition profiles of CYP2D6 by reference inhibitor: Quinidine (0.1-1-2-5-10-100 ÎźM). Results are presented as mean rate values Âą SE (from three independent experiments) of (E/Z)-endoxifen formation in vitro expre

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Additional file 8: of Absence of herb-drug interactions of mistletoe with the tamoxifen metabolite (E/Z)-endoxifen and cytochrome P450 3A4/5 and 2D6 in vitro

Autor: U. Weissenstein, M. Kunz, M. Oufir, J. Wang, M. Hamburger, K. Urech, U. Regueiro, S. Baumgartner

Figure S5. Tamoxifen in vitro inhibition profile of CYP3A4/5 by reference inhibitor: Ketoconazole (0.1-1-2-5-10-100 ÎźM). Results are presented as mean rate values Âą SE (from three independent experiments) of (E/Z)-endoxifen formation in vitro e

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