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Allosteric characteristics of GTP cyclohydrolase I from Escherichia coli

Autor: Nenad Blau, U. Redweik, Gabriele Schoedon, Richard G. H. Cotton, Gerhard Frank

Publikováno v: European Journal of Biochemistry. 210:561-568

The kinetic and regulatory properties of GTP cyclohydrolase I were investigated using an improved enzyme assay and direct determination of the product, dihydroneopterin triphosphate. The enzyme was purified from Escherichia coli to absolute homogenei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680411026c4d9f3433274cd73d0f76a4
https://doi.org/10.1111/j.1432-1033.1992.tb17455.x

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Purification and Characterization of 6-Pyruvoyl Tetrahydropterin Synthase from Human Pituitary Gland

Autor: Otmar D. Wiestler, Claus W. Heizmann, U. Redweik, Jaime Guzman, Peter Hunziker, Nenad Blau, Gabriele Schoedon

Publikováno v: Europe PubMed Central

6-Pyruvoyl tetrahydropterin synthase, the enzyme that catalyses the conversion of 7,8-dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, was purified 3,330-fold from human pituitary gland with an overall recovery of 30%. The native enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4018ae0a11e7d930fc637512effa25
https://doi.org/10.1159/000468806

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Detection of sepiapterin in CSF of patients with sepiapterin reductase deficiency

Autor: Beat Thöny, U. Redweik, Johann Penzien, Nenad Blau, Heike Trippe, Giovanna Zorzi

Publikováno v: Molecular genetics and metabolism. 75(2)

Sepiapterin reductase (SR) deficiency was recently described in patients with a severe biogenic amine deficiency presenting without hyperphenylalaninemia and it was suggested that the tetrahydrobiopterin (BH(4)) pathway may be different in different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b29acb8de90a561b4a8d9da1eb6716
https://pubmed.ncbi.nlm.nih.gov/11855937

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6-Pyruvoyl tetrahydropterin synthase, an enzyme with a novel type of active site involving both zinc binding and an intersubunit catalytic triad motif; site-directed mutagenesis of the proposed active center, characterization of the metal binding site and modelling of substrate binding

Autor: Herbert Nar, Claus W. Heizmann, Daniel M. Bürgisser, Beat Thöny, U. Redweik, Daniel Hess, Robert Huber

Publikováno v: Journal of molecular biology. 253(2)

6-Pyruvoyl tetrahydropterin synthase (PTPS) is an enzyme involved in tetrahydrobiopterin biosynthesis, the cofactor for several aromatic aminoacid monooxygenases and the nitric oxide synthases. The crystal structure of PTPS was recently solved and sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a6cbcac8e7d85e482a0e15574fbe97
https://pubmed.ncbi.nlm.nih.gov/7563095

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Expression and characterization of recombinant human and rat liver 6-pyruvoyl tetrahydropterin synthase. Modified cysteine residues inhibit the enzyme activity

Autor: Claus W. Heizmann, Peter Hunziker, Nenad Blau, U. Redweik, Daniel M. Bürgisser, Beat Thöny

Publikováno v: European journal of biochemistry. 219(1-2)

6-Pyruvoyl-tetrahydropterin synthase is the rate-limiting enzyme in the synthesis of human tetrahydrobiopterin, a cofactor for several hydroxylases involved in catecholamine and serotonin biosynthesis. The human and rat liver cDNAs encoding the 16-kD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77eadc68da639135f575f2609d8a741
https://pubmed.ncbi.nlm.nih.gov/8307017

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