Zobrazeno 1 - 10
of 24
pro vyhledávání: '"U. R. Kees"'
Autor:
L. Fransecky, M. Neumann, S. Heesch, C. Schlee, J. Ortiz-Tanchez, S. Heller, M. Mossner, S. Schwartz, L. H. Mochmann, K. Isaakidis, L. Bastian, U. R. Kees, T. Herold, K. Spiekermann, N. Gökbuget, C. D. Baldus
Publikováno v:
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-12 (2016)
Abstract Background GATA3 is pivotal for the development of T lymphocytes. While its effects in later stages of T cell differentiation are well recognized, the role of GATA3 in the generation of early T cell precursors (ETP) has only recently been ex
Externí odkaz:
https://doaj.org/article/4c6c66b24eb547a482695c7814df8700
Publikováno v:
Pediatric Hematology and Oncology. 10:55-62
A 12 year-old girl developed a late relapse of acute lymphoblastic leukaemia (ALL) 10 years from first presentation. Initial chemotherapy included vincristine, methotrexate, prednisolone, and L-asparaginase with cranial radiotherapy (18 Gy) for centr
Autor:
Terence H. Rabbitts, F Lampert, N Dear, U R Kees, Martin A. Kennedy, Rogelio González-Sarmiento, T Boehm
Publikováno v:
Proceedings of the National Academy of Sciences. 88:8900-8904
A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcript
Autor:
Y. Matsuo, Hari Om Agrawal, F Lo Coco, T Rozovskaia, Alexander Mazo, E. Feinstein, Robert Foa, Eytan Domany, Eli Canaani, Tomonori Nakamura, Godfrey S. Getz, Sergei Tillib, Arnon Nagler, Giuseppe Cimino, Eric F. Rappaport, Carlo M. Croce, Irina Issaeva, U. R. Kees, Tsvee Lapidot, O. Ravid-Amir
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(13)
The ALL-1 gene is directly involved in 5–10% of acute lymphoblastic leukemias (ALLs) and acute myeloid leukemias (AMLs) by fusion to other genes or through internal rearrangements. DNA microarrays were used to determine expression profiles of ALLs
Publikováno v:
British journal of haematology. 113(2)
Current risk-adjusted intensive therapies for childhood acute lymphoblastic leukaemia (ALL) are expected to result in an event-free survival of greater than 75%. In sharp contrast, relapsed paediatric ALL is a difficult disease to treat. In this stud
Autor:
S P, Whitman, M P, Strout, G, Marcucci, A G, Freud, L L, Culley, N J, Zeleznik-Le, K, Mrózek, K S, Theil, U R, Kees, C D, Bloomfield, M A, Caligiuri
Publikováno v:
Cancer research. 61(1)
A partial nontandem duplication (PNTD) of mixed lineage leukemia (MLL) gene is described in B-cell acute lymphoid leukemia without structural cytogenetic abnormalities at 11q23 and 9p22. A duplicated portion of MLL is interrupted by the insertion of
Autor:
S, O'Neill, L, Ekstrom, M, Lastowska, P, Roberts, G M, Brodeur, U R, Kees, M, Schwab, N, Bown
Publikováno v:
Genes, chromosomescancer. 30(1)
MYCN oncogene amplification in neuroblastoma is statistically associated with gain of chromosome segment 17q21-qter. In neuroblastoma cell lines and primary tumors with MYCN amplification in the form of homogeneously staining regions (hsrs), juxtapos
Publikováno v:
Genes, chromosomescancer. 29(4)
Despite considerable work on the epigenetic control of tumor suppressor genes, little is known about the potential role of promoter CpG demethylation in the activation of oncogenes in lymphoid tumors. The HOX11 proto-oncogene is frequently activated
Autor:
G. Dadd, U. R. Kees, P. J. Price, David L. Baker, M. L. N. Willoughby, Catherine H. Cole, F. G. Cameron, M. B. Phillips
Publikováno v:
Pediatric hematology and oncology. 16(4)
The total care unit for the treatment of pediatric hematology/oncology in Perth, Australia is so named to embody the philosophy of multidisciplinary care of children and their families. Where possible, patients are treated according to randomized con
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(12)
Nitric oxide (NO) has been invoked as an important pathogenic factor in a wide range of immunologically mediated diseases. The present study demonstrates that macrophage-derived NO may conversely function to fine tune T cell-mediated inflammation via