Zobrazeno 1 - 10 of 73 pro vyhledávání: '"U. Pleiß"'
1
Labelling of the guanylate cyclase activator cinaciguat (BAY 58-2667) with carbon-14, tritium and stable isotopes
Autor: U. Pleiß, D. Seidel
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 53:130-139
For studies of pharmacokinetics and drug metabolism of the new soluble guanylate cyclase activator cinaciguat (BAY 58-2667) the 14C-labelled compound was synthesized. The tritiated compound was required to elucidate the mode of action and the stable
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52a53fd398c8c0d74f1aa96e159ca8c1
https://doi.org/10.1002/jlcr.1738
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2
1,4-Dihydropyridines (DHPs) – a class of very potent drugs: syntheses of isotopically labeled DHP derivatives during the last four decades
Autor: U. Pleiss
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 50:818-830
1,4-Dihydropyridines (DHPs) belonging to the group of calcium antagonists or calcium channel blockers' are among the most important drugs used in the treatment of cardiovascular diseases. During the development processes all candidates on the market
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efe863bb9dc1582eb7c95a053406e513
https://doi.org/10.1002/jlcr.1418
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3
Synthesis of a11C-labelled taxane derivative by [1-11C]acetylation
Autor: J. Zessin, P. Mäding, F. Wüst, U. Pleiß, F. Füchtner
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 49:357-365
The 11C-labelling of the taxane derivative BAY 59-8862 (1), a potent anticancer drug, was carried out as a module-assisted automated multi-step synthesis procedure. The radiotracer [11C]1 was synthesized by reacting [1-11C]acetyl chloride (6) with th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bafa73f8279347aa042c64891a982be5
https://doi.org/10.1002/jlcr.1059
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4
Syntheses of [14C]BAY 59-7939 and its radiolabeled metabolite M-4
Autor: U. Pleiss, R. Grosser, D. Seidel
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 49:929-934
BAY 59-7939 is a novel, oral, direct Factor Xa inhibitor in clinical development for the prevention and treatment of thromboembolic diseases. Radiolabeled BAY 59-7939 was required for drug absorption, distribution, metabolism and excretion (ADME stud
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25da74e35f38895421388d449b918618
https://doi.org/10.1002/jlcr.1103
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5
Pharmacokinetics of BAY 59-7939 – an oral, direct Factor Xa inhibitor – in rats and dogs
Autor: W. Steinke, T. Schwarz, U. Pleiss, H.-P. Daehler, S. Sandmann, C. Weinz, K.-H. Schlemmer, U. Buetehorn, C. Kohlsdorfer
Publikováno v: Xenobiotica. 35:891-910
The pharmacokinetics of BAY 59-7939 - a novel, oral, direct Factor Xa inhibitor - were investigated in rats and dogs in support of preclinical safety studies and clinical development. BAY 59-7939 was rapidly absorbed after oral dosing, with an absolu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190f6158a2c735f5581d140a74577e74
https://doi.org/10.1080/00498250500250493
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7
Biokinetic model for the calculation of dose coefficients for oral and intravenous administration of 14C labeled drugs
Autor: A. Krins, J. Fidorra, U. Pleiß, P. Sahre, T. Schönmuth
Publikováno v: Kerntechnik. 68:205-213
A first order biokinetic model is presented for the calculation of dose coefficients from human activity excretion data after intravenous and oral administration of 14C labeled drugs. It is intended for the dose estimation in human studies in drug re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec87d7be5614d8cd59d1c36a2fa6ad02
https://doi.org/10.1515/kern-2003-0083
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9
High Affinity Binding of a Potassium Channel Agonist to Intact Rat Insulinoma Cells
Autor: R.A. Janis, U. Pleiss, E. Niemers, F.J. Hoffman, J.B. Lenfers, A. Scriabine
Publikováno v: Biochemical and Biophysical Research Communications. 190:551-558
The specific binding of a novel tritiated K+ channel opener, [3H]BAY X 9228, has been characterized in a rat insulinoma (RINm5F) cell line. The KD was 2.1 nM and Bmax 50 fmol/mg total protein as determined by saturation analysis. The high affinity bi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756bf5e50f015c56dfee5a4bb4e7f72e
https://doi.org/10.1006/bbrc.1993.1083
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10
ChemInform Abstract: 1,4-Dihydropyridines (DHPs): A Class of Very Potent Drugs - Syntheses of Isotopically Labeled DHP Derivatives During the Last Four Decades
Autor: U. Pleiss
Publikováno v: ChemInform. 39
1,4-Dihydropyridines (DHPs) belonging to the group of calcium antagonists or calcium channel blockers' are among the most important drugs used in the treatment of cardiovascular diseases. During the development processes all candidates on the market
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e6806d0c55a2fb9c9604151dd3fa2f2
https://doi.org/10.1002/chin.200842243
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