Zobrazeno 1 - 10
of 55
pro vyhledávání: '"U. Murali Krishna"'
Autor:
U. Murali Krishna, Peter Koslosky, Krishnudu Kasireddy, Shoukath M. Ali, Imran Ahmad, Moghis U. Ahmad
Publikováno v:
Tetrahedron. 62:6990-6997
A phosphoramidite approach using 2-cyanoethyl N,N-diisopropylchlorophosphoramidite was utilized for the first time to synthesize short chain cardiolipins. The approach was extended to synthesize long chain and their ether analogue. Optically active 1
Autor:
Kamalesh K. Sharma, Y. Krishna Reddy, K. Malla Reddy, Kathryn M. Gauthier, Christine Deeter, William B. Campbell, Sarah B. Hittner, P. Srinagesh Kumar, John R. Falck, U. Murali Krishna
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 284:H337-H349
Epoxyeicosatrienoic acids (EETs) are endothelium-derived eicosanoids that activate potassium channels, hyperpolarize the membrane, and cause relaxation. We tested 19 analogs of 14,15-EET on vascular tone to determine the structural features required
Publikováno v:
Microvascular Research. 64:349-352
Publikováno v:
American Journal of Physiology-Renal Physiology. 282:F826-F834
We have recently reported that direct interaction between phosphatidylinositol bisphosphate (PIP2) and the COOH-terminal cytoplasmic domain of ROMK1 is important for opening of the channel. We identified arginine-188 of ROMK1 as a critical residue fo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2415-2418
An effective synthesis is described for the preparation of all four mono trans isomers of arachidonic acid via deoxidation of epoxide precursors with lithium diphenylphosphide and quaternization with methyl iodide.
Autor:
H. Neil Freeman, Brigitte Ritter, U. Murali Krishna, Jan Modregger, Markus Plomann, Andrew B. Tobin, Joanne M. Hilton, John R. Falck
Publikováno v:
Journal of Biological Chemistry. 276:16341-16347
Despite the fact that inositol hexakisphosphate (InsP(6)) is the most abundant inositol metabolite in cells, its cellular function has remained an enigma. In the present study, we present the first evidence of a protein kinase identified in rat cereb
Publikováno v:
Microcirculation. 8:115-127
Publikováno v:
Microcirculation. 8:45-55
Objective:To evaluate the role of 20-hydroxyeicosatetraenoic acid (20-HETE), a product of arachidonic acid ω-hydroxylation via cytochrome P450 (CP450) 4A enzymes, in regulating myogenic activation of skeletal muscle resistance arteries from normoten
Autor:
U. Murali Krishna
Publikováno v:
Tetrahedron Letters. 51:2148-2150
An elegant approach for stereocontrolled synthesis of furopyran (hexahydro-2 H -furo[3,2- b ]pyran) building blocks was reported. The key steps in the sequence involved an efficient intramolecular 3-oxidopyrylium-alkene [5+2] cycloaddition for the sy
Publikováno v:
Tetrahedron Letters. 41:4271-4275
Highly efficient, asymmetric total syntheses of the title phospholipids as well as short chain and cross-linkable aminoether analogs were achieved in five to seven steps from a readily available myo -inositol derivative.