Zobrazeno 1 - 10
of 18
pro vyhledávání: '"U. M. Zanger"'
Publikováno v:
The Pharmacogenomics Journal. 3:335-342
The present study investigated the effect of cytochrome P450 2C9 (CYP2C9) genetic polymorphism on the biotransformation of valproic acid (VPA) to its hepatotoxic metabolite, 4-ene-VPA, and compared that to the formation of the inactive 4-OH-VPA and 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9708044c8df11d0ac0e226d84b154ec
https://doi.org/10.1038/sj.tpj.6500210
https://doi.org/10.1038/sj.tpj.6500210
Publikováno v:
Xenobiotica. 26:107-116
1. Epoxide hydrolases form an enzyme family involved in the metabolism of a variety of xenobiotics including cytostatic drugs and carcinogens. Whether human microsomal epoxide hydrolase--one of the main members of the epoxide hydrolase family--is exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c78c9d1f1142c78a9948b3f8773102
https://doi.org/10.3109/00498259609046692
https://doi.org/10.3109/00498259609046692
Publikováno v:
Deutsche medizinische Wochenschrift (1946). 136(10)
Pharmacogenomics follows the concept of individualized medicine via targeted and tailored therapy for each patient. This is aided by current progress in human genome research that provided the basis to link genetic markers with pathogenesis and progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d755533cc1cae5a29661a0e032d5687e
https://pubmed.ncbi.nlm.nih.gov/21365522
https://pubmed.ncbi.nlm.nih.gov/21365522
Publikováno v:
Journal of Biological Chemistry. 268:3952-3963
Pituitary-derived trophic hormones regulate cell-type-specific expression of VL30 retrotransposons in tissues that are engaged in steroidogenesis. We show that adrenocorticotropic hormone and forskolin induced VL30 transcription in the steroidogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aed645204f9a61da20204fcd00831385
https://doi.org/10.1016/s0021-9258(18)53564-x
https://doi.org/10.1016/s0021-9258(18)53564-x
Publikováno v:
Journal of Biological Chemistry. 265:17197-17201
A cDNA coding for an allelic variant of rat IID1, designated IID1v, was isolated that produced a P-450 having a 10-fold lower catalytic activity toward the substrate bufuralol when expressed in COS-1 cells (Matsunaga, E., Zanger, U. M., Hardwick, J.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15cc520ff0ac322d59b6aba3fa86d473
https://doi.org/10.1016/s0021-9258(17)44888-5
https://doi.org/10.1016/s0021-9258(17)44888-5
Autor:
A. Telenti, U. M. Zanger
Publikováno v:
Annual review of pharmacology and toxicology. 48
Pharmacogenetics holds promise in HIV treatment because of the complexity and potential toxicity of multidrug therapies that are prescribed for long periods. Thus far, few candidate genes have been examined for a limited number of allelic variants, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e244403cfe7cf5e2e3dbd4e1005d704
https://pubmed.ncbi.nlm.nih.gov/17883329
https://pubmed.ncbi.nlm.nih.gov/17883329
Publikováno v:
Senologie - Zeitschrift für Mammadiagnostik und -therapie. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbfd3b593b8e44b32b1acefa1d3479ea
https://doi.org/10.1055/s-2005-917721
https://doi.org/10.1055/s-2005-917721
Publikováno v:
The Histochemical journal. 33(6)
Microsomal epoxide hydrolase is a biotransformation enzyme which is involved in the hydrolysis of various epoxides and epoxide intermediates. In the present study, its distribution was investigated in both normal human tissues and human tumours of di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ffe09b76af227cf68b6a5b3c36d65827
https://pubmed.ncbi.nlm.nih.gov/11758809
https://pubmed.ncbi.nlm.nih.gov/11758809
Autor:
T, Lang, K, Klein, J, Fischer, A K, Nüssler, P, Neuhaus, U, Hofmann, M, Eichelbaum, M, Schwab, U M, Zanger
Publikováno v:
Pharmacogenetics. 11(5)
The human cytochrome P450, CYP2B6, is involved in the metabolism of several therapeutically important drugs and environmental or abused toxicants. In this study, we present the first systematic investigation of genetic polymorphism in the CYP2B6 gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ed469747cc6b82318e01696681f5b06
https://pubmed.ncbi.nlm.nih.gov/11470993
https://pubmed.ncbi.nlm.nih.gov/11470993
Autor:
R, Eiselt, T L, Domanski, A, Zibat, R, Mueller, E, Presecan-Siedel, E, Hustert, U M, Zanger, J, Brockmoller, H P, Klenk, U A, Meyer, K K, Khan, Y A, He, J R, Halpert, L, Wojnowski
Publikováno v:
Pharmacogenetics. 11(5)
The genetic component of the inter-individual variability in CYP3A4 activity has been estimated to be between 60% and 90%, but the underlying genetic factors remain largely unknown. A study of 213 Middle and Western European DNA samples resulted in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9cc33a50114409bfc7348f584479dd7a
https://pubmed.ncbi.nlm.nih.gov/11470997
https://pubmed.ncbi.nlm.nih.gov/11470997